Local administration of growth hormone stimulates tendon collagen synthesis in elderly men

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Local administration of growth hormone stimulates tendon collagen synthesis in elderly men. / Vestergaard, Poul Erik; Jørgensen, Jens Otto Lunde; Olesen, Jens; Bosnjak, Ermina; Holm, Lars; Frystyk, Jan; Langberg, Henning; Kjaer, Michael; Hansen, Mette Damborg.

In: Journal of Applied Physiology, Vol. 113, No. 9, 11.2012, p. 1432-8.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Vestergaard, PE, Jørgensen, JOL, Olesen, J, Bosnjak, E, Holm, L, Frystyk, J, Langberg, H, Kjaer, M & Hansen, MD 2012, 'Local administration of growth hormone stimulates tendon collagen synthesis in elderly men', Journal of Applied Physiology, vol. 113, no. 9, pp. 1432-8. https://doi.org/10.1152/japplphysiol.00816.2012

APA

Vestergaard, P. E., Jørgensen, J. O. L., Olesen, J., Bosnjak, E., Holm, L., Frystyk, J., ... Hansen, M. D. (2012). Local administration of growth hormone stimulates tendon collagen synthesis in elderly men. Journal of Applied Physiology, 113(9), 1432-8. https://doi.org/10.1152/japplphysiol.00816.2012

Vancouver

Vestergaard PE, Jørgensen JOL, Olesen J, Bosnjak E, Holm L, Frystyk J et al. Local administration of growth hormone stimulates tendon collagen synthesis in elderly men. Journal of Applied Physiology. 2012 Nov;113(9):1432-8. https://doi.org/10.1152/japplphysiol.00816.2012

Author

Vestergaard, Poul Erik ; Jørgensen, Jens Otto Lunde ; Olesen, Jens ; Bosnjak, Ermina ; Holm, Lars ; Frystyk, Jan ; Langberg, Henning ; Kjaer, Michael ; Hansen, Mette Damborg. / Local administration of growth hormone stimulates tendon collagen synthesis in elderly men. In: Journal of Applied Physiology. 2012 ; Vol. 113, No. 9. pp. 1432-8.

Bibtex

@article{208024e458564c48b60bc83a85865b55,
title = "Local administration of growth hormone stimulates tendon collagen synthesis in elderly men",
abstract = "Tendon collagen content and circulating growth hormone (GH) are reduced in elderly. In a placebo-controlled, double-blinded study, we examined if local injections of rhGH enhance collagen synthesis in healthy elderly men (61 ± 1 yr). Two injections of rhGH or saline (control) were injected into each of the patient's patellar tendons, respectively. Subsequently, tendon collagen fractional synthesis rate (FSR) and an indirect marker of type I collagen synthesis (PINP) were measured. Within the first 6 h after the last injections, a tendency towards a higher tendon collagen FSR was observed in 10 out of 12 subjects (P = 0.08). Similarly, PINP was higher 3-4 h after the last GH injection (P = 0.05). Serum IGF-I did not change from baseline, whereas peritendinous bioactive IGF-I was higher in the GH leg vs. control (P = 0.05). In conclusion, local injections of rhGH increase tendon collagen synthesis in humans, either directly or indirectly by increasing local bioactive IGF-I.",
author = "Vestergaard, {Poul Erik} and J{\o}rgensen, {Jens Otto Lunde} and Jens Olesen and Ermina Bosnjak and Lars Holm and Jan Frystyk and Henning Langberg and Michael Kjaer and Hansen, {Mette Damborg}",
year = "2012",
month = "11",
doi = "10.1152/japplphysiol.00816.2012",
language = "English",
volume = "113",
pages = "1432--8",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "9",

}

RIS

TY - JOUR

T1 - Local administration of growth hormone stimulates tendon collagen synthesis in elderly men

AU - Vestergaard, Poul Erik

AU - Jørgensen, Jens Otto Lunde

AU - Olesen, Jens

AU - Bosnjak, Ermina

AU - Holm, Lars

AU - Frystyk, Jan

AU - Langberg, Henning

AU - Kjaer, Michael

AU - Hansen, Mette Damborg

PY - 2012/11

Y1 - 2012/11

N2 - Tendon collagen content and circulating growth hormone (GH) are reduced in elderly. In a placebo-controlled, double-blinded study, we examined if local injections of rhGH enhance collagen synthesis in healthy elderly men (61 ± 1 yr). Two injections of rhGH or saline (control) were injected into each of the patient's patellar tendons, respectively. Subsequently, tendon collagen fractional synthesis rate (FSR) and an indirect marker of type I collagen synthesis (PINP) were measured. Within the first 6 h after the last injections, a tendency towards a higher tendon collagen FSR was observed in 10 out of 12 subjects (P = 0.08). Similarly, PINP was higher 3-4 h after the last GH injection (P = 0.05). Serum IGF-I did not change from baseline, whereas peritendinous bioactive IGF-I was higher in the GH leg vs. control (P = 0.05). In conclusion, local injections of rhGH increase tendon collagen synthesis in humans, either directly or indirectly by increasing local bioactive IGF-I.

AB - Tendon collagen content and circulating growth hormone (GH) are reduced in elderly. In a placebo-controlled, double-blinded study, we examined if local injections of rhGH enhance collagen synthesis in healthy elderly men (61 ± 1 yr). Two injections of rhGH or saline (control) were injected into each of the patient's patellar tendons, respectively. Subsequently, tendon collagen fractional synthesis rate (FSR) and an indirect marker of type I collagen synthesis (PINP) were measured. Within the first 6 h after the last injections, a tendency towards a higher tendon collagen FSR was observed in 10 out of 12 subjects (P = 0.08). Similarly, PINP was higher 3-4 h after the last GH injection (P = 0.05). Serum IGF-I did not change from baseline, whereas peritendinous bioactive IGF-I was higher in the GH leg vs. control (P = 0.05). In conclusion, local injections of rhGH increase tendon collagen synthesis in humans, either directly or indirectly by increasing local bioactive IGF-I.

U2 - 10.1152/japplphysiol.00816.2012

DO - 10.1152/japplphysiol.00816.2012

M3 - Journal article

VL - 113

SP - 1432

EP - 1438

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 9

ER -

ID: 44832886