Myogenic, matrix and growth factor mRNA expression in human skeletal muscle: effect of contraction intensity and feeding

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Myogenic, matrix and growth factor mRNA expression in human skeletal muscle: effect of contraction intensity and feeding. / Agergaard, Jakob; Reitelseder, Søren; Pedersen, T.G.; Doessing, Simon; Schjerling, Peter; Langberg, Henning; Miller, Benjamin F; Aagaard, P; Kjær, Michael; Holm, Lars.

In: Muscle & Nerve, Vol. 47, No. 5, 20.03.2013, p. 748-759.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Agergaard, J, Reitelseder, S, Pedersen, TG, Doessing, S, Schjerling, P, Langberg, H, Miller, BF, Aagaard, P, Kjær, M & Holm, L 2013, 'Myogenic, matrix and growth factor mRNA expression in human skeletal muscle: effect of contraction intensity and feeding', Muscle & Nerve, vol. 47, no. 5, pp. 748-759. https://doi.org/10.1002/mus.23667

APA

Agergaard, J., Reitelseder, S., Pedersen, T. G., Doessing, S., Schjerling, P., Langberg, H., ... Holm, L. (2013). Myogenic, matrix and growth factor mRNA expression in human skeletal muscle: effect of contraction intensity and feeding. Muscle & Nerve, 47(5), 748-759. https://doi.org/10.1002/mus.23667

Vancouver

Agergaard J, Reitelseder S, Pedersen TG, Doessing S, Schjerling P, Langberg H et al. Myogenic, matrix and growth factor mRNA expression in human skeletal muscle: effect of contraction intensity and feeding. Muscle & Nerve. 2013 Mar 20;47(5):748-759. https://doi.org/10.1002/mus.23667

Author

Agergaard, Jakob ; Reitelseder, Søren ; Pedersen, T.G. ; Doessing, Simon ; Schjerling, Peter ; Langberg, Henning ; Miller, Benjamin F ; Aagaard, P ; Kjær, Michael ; Holm, Lars. / Myogenic, matrix and growth factor mRNA expression in human skeletal muscle: effect of contraction intensity and feeding. In: Muscle & Nerve. 2013 ; Vol. 47, No. 5. pp. 748-759.

Bibtex

@article{295a69e3fa3d40b6ad5139885e7bfe83,
title = "Myogenic, matrix and growth factor mRNA expression in human skeletal muscle: effect of contraction intensity and feeding",
abstract = "INTRODUCTION: We examined short-term (3-hour) and long-term (12-week) training effects after heavy load [HL; 70{\%} 1RM] and light load (LL; 16{\%} 1RM) exercise. METHODS: mRNA expression of genes involved in skeletal muscle remodeling were analyzed and muscle activity (EMG measurements) was measured. RESULTS: Relative muscle activity differed between HL and LL resistance exercise, whereas median power frequency was even, suggesting an equal muscle-fiber-type recruitment distribution. mRNA expression of Myf6, myogenin, and p21 was mostly increased, and myostatin was mostly depressed by HL resistance exercise. No major differences were seen in atrophy-related genes between HL and LL resistance exercise. No changes were seen over 12-week training for any of the targets. CONCLUSIONS: Resistance exercise at LL and HL elevated the expression of genes involved in skeletal muscle hypertrophy, although the greatest response was from HL. However, no long-term effect from either LL or HL resistance exercise was seen on basal levels of the mRNA targets.",
author = "Jakob Agergaard and S{\o}ren Reitelseder and T.G. Pedersen and Simon Doessing and Peter Schjerling and Henning Langberg and Miller, {Benjamin F} and P Aagaard and Michael Kj{\ae}r and Lars Holm",
year = "2013",
month = "3",
day = "20",
doi = "10.1002/mus.23667",
language = "English",
volume = "47",
pages = "748--759",
journal = "Muscle & Nerve",
issn = "0148-639X",
publisher = "JohnWiley & Sons, Inc.",
number = "5",

}

RIS

TY - JOUR

T1 - Myogenic, matrix and growth factor mRNA expression in human skeletal muscle: effect of contraction intensity and feeding

AU - Agergaard, Jakob

AU - Reitelseder, Søren

AU - Pedersen, T.G.

AU - Doessing, Simon

AU - Schjerling, Peter

AU - Langberg, Henning

AU - Miller, Benjamin F

AU - Aagaard, P

AU - Kjær, Michael

AU - Holm, Lars

PY - 2013/3/20

Y1 - 2013/3/20

N2 - INTRODUCTION: We examined short-term (3-hour) and long-term (12-week) training effects after heavy load [HL; 70% 1RM] and light load (LL; 16% 1RM) exercise. METHODS: mRNA expression of genes involved in skeletal muscle remodeling were analyzed and muscle activity (EMG measurements) was measured. RESULTS: Relative muscle activity differed between HL and LL resistance exercise, whereas median power frequency was even, suggesting an equal muscle-fiber-type recruitment distribution. mRNA expression of Myf6, myogenin, and p21 was mostly increased, and myostatin was mostly depressed by HL resistance exercise. No major differences were seen in atrophy-related genes between HL and LL resistance exercise. No changes were seen over 12-week training for any of the targets. CONCLUSIONS: Resistance exercise at LL and HL elevated the expression of genes involved in skeletal muscle hypertrophy, although the greatest response was from HL. However, no long-term effect from either LL or HL resistance exercise was seen on basal levels of the mRNA targets.

AB - INTRODUCTION: We examined short-term (3-hour) and long-term (12-week) training effects after heavy load [HL; 70% 1RM] and light load (LL; 16% 1RM) exercise. METHODS: mRNA expression of genes involved in skeletal muscle remodeling were analyzed and muscle activity (EMG measurements) was measured. RESULTS: Relative muscle activity differed between HL and LL resistance exercise, whereas median power frequency was even, suggesting an equal muscle-fiber-type recruitment distribution. mRNA expression of Myf6, myogenin, and p21 was mostly increased, and myostatin was mostly depressed by HL resistance exercise. No major differences were seen in atrophy-related genes between HL and LL resistance exercise. No changes were seen over 12-week training for any of the targets. CONCLUSIONS: Resistance exercise at LL and HL elevated the expression of genes involved in skeletal muscle hypertrophy, although the greatest response was from HL. However, no long-term effect from either LL or HL resistance exercise was seen on basal levels of the mRNA targets.

U2 - 10.1002/mus.23667

DO - 10.1002/mus.23667

M3 - Journal article

VL - 47

SP - 748

EP - 759

JO - Muscle & Nerve

JF - Muscle & Nerve

SN - 0148-639X

IS - 5

ER -

ID: 129774691