Negative interstitial pressure in the peritendinous region during exercise

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Negative interstitial pressure in the peritendinous region during exercise. / Langberg, Henning; Skovgaard, D; Bülow, J; Kjaer, M.

In: Journal of Applied Physiology, Vol. 87, No. 3, 1999, p. 999-1002.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Langberg, H, Skovgaard, D, Bülow, J & Kjaer, M 1999, 'Negative interstitial pressure in the peritendinous region during exercise', Journal of Applied Physiology, vol. 87, no. 3, pp. 999-1002.

APA

Langberg, H., Skovgaard, D., Bülow, J., & Kjaer, M. (1999). Negative interstitial pressure in the peritendinous region during exercise. Journal of Applied Physiology, 87(3), 999-1002.

Vancouver

Langberg H, Skovgaard D, Bülow J, Kjaer M. Negative interstitial pressure in the peritendinous region during exercise. Journal of Applied Physiology. 1999;87(3):999-1002.

Author

Langberg, Henning ; Skovgaard, D ; Bülow, J ; Kjaer, M. / Negative interstitial pressure in the peritendinous region during exercise. In: Journal of Applied Physiology. 1999 ; Vol. 87, No. 3. pp. 999-1002.

Bibtex

@article{63142b60b32a4d70854d47b6c4229e9a,
title = "Negative interstitial pressure in the peritendinous region during exercise",
abstract = "In the present study, tissue pressure in the peritendinous area ventral to the human Achilles tendon was determined. The pressure was measured during rest and intermittent isometric calf muscle exercise at three torques (56, 112, and 168 Nm) 20, 40 and 50 mm proximal to the insertion of the tendon in 11 healthy, young individuals. In all experiments a linear significant decrease in pressure was obtained with increasing torque [e.g., at 40 mm: -0.4 +/- 0.3 mmHg (rest) to -135 +/- 12 mmHg (168 Nm)]. No significant differences were obtained among the three areas measured. On the basis of these observations, microdialysis was performed in the peritendinous region with a colloid osmotic active substance (Dextran 70, 0.1 g/ml) added to the perfusate with the aim of counteracting the negative tissue pressure. Dialysate volume was found to be fully restored (100 +/- 4{\%}) during exercise. It is concluded that a marked negative tissue pressure is generated in the peritendinous space around the Achilles tendon during exercise in humans. Negative tissue pressure could lead to fluid shift and could be involved in the increase in blood flow previously noted in the peritendinous tissue during exercise (H. Langberg, J. B{\"u}low, and M. Kjaer. Acta Physiol. Scand. 163: 149-153, 1998; H. Langberg, J. B{\"u}low, and M. Kjaer. Clin. Physiol. 19: 89-93, 1999).",
keywords = "Achilles Tendon, Adult, Dextrans, Exercise, Female, Humans, Male, Microdialysis, Pressure, Regional Blood Flow, Torque",
author = "Henning Langberg and D Skovgaard and J B{\"u}low and M Kjaer",
year = "1999",
language = "English",
volume = "87",
pages = "999--1002",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "3",

}

RIS

TY - JOUR

T1 - Negative interstitial pressure in the peritendinous region during exercise

AU - Langberg, Henning

AU - Skovgaard, D

AU - Bülow, J

AU - Kjaer, M

PY - 1999

Y1 - 1999

N2 - In the present study, tissue pressure in the peritendinous area ventral to the human Achilles tendon was determined. The pressure was measured during rest and intermittent isometric calf muscle exercise at three torques (56, 112, and 168 Nm) 20, 40 and 50 mm proximal to the insertion of the tendon in 11 healthy, young individuals. In all experiments a linear significant decrease in pressure was obtained with increasing torque [e.g., at 40 mm: -0.4 +/- 0.3 mmHg (rest) to -135 +/- 12 mmHg (168 Nm)]. No significant differences were obtained among the three areas measured. On the basis of these observations, microdialysis was performed in the peritendinous region with a colloid osmotic active substance (Dextran 70, 0.1 g/ml) added to the perfusate with the aim of counteracting the negative tissue pressure. Dialysate volume was found to be fully restored (100 +/- 4%) during exercise. It is concluded that a marked negative tissue pressure is generated in the peritendinous space around the Achilles tendon during exercise in humans. Negative tissue pressure could lead to fluid shift and could be involved in the increase in blood flow previously noted in the peritendinous tissue during exercise (H. Langberg, J. Bülow, and M. Kjaer. Acta Physiol. Scand. 163: 149-153, 1998; H. Langberg, J. Bülow, and M. Kjaer. Clin. Physiol. 19: 89-93, 1999).

AB - In the present study, tissue pressure in the peritendinous area ventral to the human Achilles tendon was determined. The pressure was measured during rest and intermittent isometric calf muscle exercise at three torques (56, 112, and 168 Nm) 20, 40 and 50 mm proximal to the insertion of the tendon in 11 healthy, young individuals. In all experiments a linear significant decrease in pressure was obtained with increasing torque [e.g., at 40 mm: -0.4 +/- 0.3 mmHg (rest) to -135 +/- 12 mmHg (168 Nm)]. No significant differences were obtained among the three areas measured. On the basis of these observations, microdialysis was performed in the peritendinous region with a colloid osmotic active substance (Dextran 70, 0.1 g/ml) added to the perfusate with the aim of counteracting the negative tissue pressure. Dialysate volume was found to be fully restored (100 +/- 4%) during exercise. It is concluded that a marked negative tissue pressure is generated in the peritendinous space around the Achilles tendon during exercise in humans. Negative tissue pressure could lead to fluid shift and could be involved in the increase in blood flow previously noted in the peritendinous tissue during exercise (H. Langberg, J. Bülow, and M. Kjaer. Acta Physiol. Scand. 163: 149-153, 1998; H. Langberg, J. Bülow, and M. Kjaer. Clin. Physiol. 19: 89-93, 1999).

KW - Achilles Tendon

KW - Adult

KW - Dextrans

KW - Exercise

KW - Female

KW - Humans

KW - Male

KW - Microdialysis

KW - Pressure

KW - Regional Blood Flow

KW - Torque

M3 - Journal article

C2 - 10484569

VL - 87

SP - 999

EP - 1002

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 3

ER -

ID: 38368478