Short-term acetaminophen consumption enhances the exercise-induced increase in Achilles peritendinous IL-6 in humans

Research output: Contribution to journalJournal articleResearchpeer-review

  • Brian S Gump
  • David R McMullan
  • David J Cauthon
  • Jamie A Whitt
  • Jonathon D Del Mundo
  • Tanya Letham
  • Paul J Kim
  • Gary N Friedlander
  • Pingel, Jessica
  • Langberg, Henning
  • Chad C Carroll
Through an unknown mechanism the cyclooxygenase (COX) inhibitor acetaminophen (APAP) alters tendon mechanical properties in humans when consumed during exercise. Interleukin-6 (IL-6) is produced by tendon during exercise and is a potent stimulator of collagen synthesis. In non-tendon tissue, IL-6 is upregulated in presence of COX-inhibitors and may contribute to alterations in extracellular matrix turnover, possibly due to inhibition of prostaglandin E2 (PGE2). We evaluated the effects of APAP on IL-6 and PGE2 in human Achilles peritendinous tissue after 1-hour of treadmill exercise. Subjects were randomly assigned to a placebo (n=8, 26±1 y) or APAP (n=8, 25±1 y) group. Each subject completed a non-exercise and exercise experiment consisting of 6-hours of microdialysis. Drug (APAP, 1000 mg) or placebo was administered in a double-blind manner during both experiments. PGE2 and IL-6 were determined via enzyme immunoassay and APAP via high performance liquid chromatography. In subjects given APAP, peritendinous APAP levels increased to 4.08±0.65 μg•ml(-1) (p0.05), nor was PGE2 significantly reduced in the APAP group. IL-6 levels increased with exercise in both groups (p
Original languageEnglish
JournalJournal of Applied Physiology
Issue number6
Pages (from-to)929-936
Number of pages8
Publication statusPublished - 2013

ID: 46148542