Short-term strength training and the expression of myostatin and IGF-I isoforms in rat muscle and tendon: differential effects of specific contraction types

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Short-term strength training and the expression of myostatin and IGF-I isoforms in rat muscle and tendon : differential effects of specific contraction types. / Heinemeier, K M; Olesen, J L; Schjerling, P; Haddad, F; Langberg, Henning; Baldwin, K M; Kjaer, M.

In: Journal of Applied Physiology, Vol. 102, No. 2, 2007, p. 573-81.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Heinemeier, KM, Olesen, JL, Schjerling, P, Haddad, F, Langberg, H, Baldwin, KM & Kjaer, M 2007, 'Short-term strength training and the expression of myostatin and IGF-I isoforms in rat muscle and tendon: differential effects of specific contraction types', Journal of Applied Physiology, vol. 102, no. 2, pp. 573-81. https://doi.org/10.1152/japplphysiol.00866.2006

APA

Heinemeier, K. M., Olesen, J. L., Schjerling, P., Haddad, F., Langberg, H., Baldwin, K. M., & Kjaer, M. (2007). Short-term strength training and the expression of myostatin and IGF-I isoforms in rat muscle and tendon: differential effects of specific contraction types. Journal of Applied Physiology, 102(2), 573-81. https://doi.org/10.1152/japplphysiol.00866.2006

Vancouver

Heinemeier KM, Olesen JL, Schjerling P, Haddad F, Langberg H, Baldwin KM et al. Short-term strength training and the expression of myostatin and IGF-I isoforms in rat muscle and tendon: differential effects of specific contraction types. Journal of Applied Physiology. 2007;102(2):573-81. https://doi.org/10.1152/japplphysiol.00866.2006

Author

Heinemeier, K M ; Olesen, J L ; Schjerling, P ; Haddad, F ; Langberg, Henning ; Baldwin, K M ; Kjaer, M. / Short-term strength training and the expression of myostatin and IGF-I isoforms in rat muscle and tendon : differential effects of specific contraction types. In: Journal of Applied Physiology. 2007 ; Vol. 102, No. 2. pp. 573-81.

Bibtex

@article{190dde7d3cc74305b6d2204f7dfe0dce,
title = "Short-term strength training and the expression of myostatin and IGF-I isoforms in rat muscle and tendon: differential effects of specific contraction types",
abstract = "In skeletal muscle, an increased expression of insulin like growth factor-I isoforms IGF-IEa and mechano-growth factor (MGF) combined with downregulation of myostatin is thought to be essential for training-induced hypertrophy. However, the specific effects of different contraction types on regulation of these factors in muscle are still unclear, and in tendon the functions of myostatin, IGF-IEa, and MGF in relation to training are unknown. Female Sprague-Dawley rats were subjected to 4 days of concentric, eccentric, or isometric training (n = 7-9 per group) of the medial gastrocnemius, by stimulation of the sciatic nerve during general anesthesia. mRNA levels for myostatin, IGF-IEa, and MGF in muscle and Achilles' tendon were measured by real-time RT-PCR. Muscle myostatin mRNA decreased in response to all types of training (2- to 8-fold) (P <0.05), but the effect of eccentric training was greater than concentric and isometric training (P <0.05). In tendon, myostatin mRNA was detected, but no changes were seen after exercise. IGF-IEa and MGF increased in muscle (up to 15-fold) and tendon (up to 4-fold) in response to training (P <0.01). In tendon no difference was seen between training types, but in muscle the effect of eccentric training was greater than concentric training for both IGF-IEa and MGF (P <0.05), and for IGF-IEa isometric training had greater effect than concentric (P <0.05). The results indicate a possible role for IGF-IEa and MGF in adaptation of tendon to training, and the combined changes in myostatin and IGF-IEa/MGF expression could explain the important effect of eccentric actions for muscle hypertrophy.",
keywords = "Animals, Female, Gene Expression Regulation, Hypertrophy, Insulin-Like Growth Factor I, Isometric Contraction, Muscle Contraction, Muscle, Skeletal, Myostatin, Physical Conditioning, Animal, Protein Isoforms, RNA, Messenger, Random Allocation, Rats, Rats, Sprague-Dawley, Tendons, Transforming Growth Factor beta",
author = "Heinemeier, {K M} and Olesen, {J L} and P Schjerling and F Haddad and Henning Langberg and Baldwin, {K M} and M Kjaer",
year = "2007",
doi = "10.1152/japplphysiol.00866.2006",
language = "English",
volume = "102",
pages = "573--81",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "2",

}

RIS

TY - JOUR

T1 - Short-term strength training and the expression of myostatin and IGF-I isoforms in rat muscle and tendon

T2 - differential effects of specific contraction types

AU - Heinemeier, K M

AU - Olesen, J L

AU - Schjerling, P

AU - Haddad, F

AU - Langberg, Henning

AU - Baldwin, K M

AU - Kjaer, M

PY - 2007

Y1 - 2007

N2 - In skeletal muscle, an increased expression of insulin like growth factor-I isoforms IGF-IEa and mechano-growth factor (MGF) combined with downregulation of myostatin is thought to be essential for training-induced hypertrophy. However, the specific effects of different contraction types on regulation of these factors in muscle are still unclear, and in tendon the functions of myostatin, IGF-IEa, and MGF in relation to training are unknown. Female Sprague-Dawley rats were subjected to 4 days of concentric, eccentric, or isometric training (n = 7-9 per group) of the medial gastrocnemius, by stimulation of the sciatic nerve during general anesthesia. mRNA levels for myostatin, IGF-IEa, and MGF in muscle and Achilles' tendon were measured by real-time RT-PCR. Muscle myostatin mRNA decreased in response to all types of training (2- to 8-fold) (P <0.05), but the effect of eccentric training was greater than concentric and isometric training (P <0.05). In tendon, myostatin mRNA was detected, but no changes were seen after exercise. IGF-IEa and MGF increased in muscle (up to 15-fold) and tendon (up to 4-fold) in response to training (P <0.01). In tendon no difference was seen between training types, but in muscle the effect of eccentric training was greater than concentric training for both IGF-IEa and MGF (P <0.05), and for IGF-IEa isometric training had greater effect than concentric (P <0.05). The results indicate a possible role for IGF-IEa and MGF in adaptation of tendon to training, and the combined changes in myostatin and IGF-IEa/MGF expression could explain the important effect of eccentric actions for muscle hypertrophy.

AB - In skeletal muscle, an increased expression of insulin like growth factor-I isoforms IGF-IEa and mechano-growth factor (MGF) combined with downregulation of myostatin is thought to be essential for training-induced hypertrophy. However, the specific effects of different contraction types on regulation of these factors in muscle are still unclear, and in tendon the functions of myostatin, IGF-IEa, and MGF in relation to training are unknown. Female Sprague-Dawley rats were subjected to 4 days of concentric, eccentric, or isometric training (n = 7-9 per group) of the medial gastrocnemius, by stimulation of the sciatic nerve during general anesthesia. mRNA levels for myostatin, IGF-IEa, and MGF in muscle and Achilles' tendon were measured by real-time RT-PCR. Muscle myostatin mRNA decreased in response to all types of training (2- to 8-fold) (P <0.05), but the effect of eccentric training was greater than concentric and isometric training (P <0.05). In tendon, myostatin mRNA was detected, but no changes were seen after exercise. IGF-IEa and MGF increased in muscle (up to 15-fold) and tendon (up to 4-fold) in response to training (P <0.01). In tendon no difference was seen between training types, but in muscle the effect of eccentric training was greater than concentric training for both IGF-IEa and MGF (P <0.05), and for IGF-IEa isometric training had greater effect than concentric (P <0.05). The results indicate a possible role for IGF-IEa and MGF in adaptation of tendon to training, and the combined changes in myostatin and IGF-IEa/MGF expression could explain the important effect of eccentric actions for muscle hypertrophy.

KW - Animals

KW - Female

KW - Gene Expression Regulation

KW - Hypertrophy

KW - Insulin-Like Growth Factor I

KW - Isometric Contraction

KW - Muscle Contraction

KW - Muscle, Skeletal

KW - Myostatin

KW - Physical Conditioning, Animal

KW - Protein Isoforms

KW - RNA, Messenger

KW - Random Allocation

KW - Rats

KW - Rats, Sprague-Dawley

KW - Tendons

KW - Transforming Growth Factor beta

U2 - 10.1152/japplphysiol.00866.2006

DO - 10.1152/japplphysiol.00866.2006

M3 - Journal article

VL - 102

SP - 573

EP - 581

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 2

ER -

ID: 38366095