The effect of a multimodal intervention on treatment-related symptoms in patients undergoing hematopoietic stem cell transplantation: a randomized controlled trial

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

The effect of a multimodal intervention on treatment-related symptoms in patients undergoing hematopoietic stem cell transplantation: a randomized controlled trial. / Jarden, Mary; Nelausen, Knud; Hovgaard, Doris; Boesen, Ellen; Adamsen, Lis.

In: Journal of Pain and Symptom Management, Vol. 38, No. 2, 2009, p. 174-90.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Jarden, M, Nelausen, K, Hovgaard, D, Boesen, E & Adamsen, L 2009, 'The effect of a multimodal intervention on treatment-related symptoms in patients undergoing hematopoietic stem cell transplantation: a randomized controlled trial', Journal of Pain and Symptom Management, vol. 38, no. 2, pp. 174-90. https://doi.org/10.1016/j.jpainsymman.2008.09.005

APA

Jarden, M., Nelausen, K., Hovgaard, D., Boesen, E., & Adamsen, L. (2009). The effect of a multimodal intervention on treatment-related symptoms in patients undergoing hematopoietic stem cell transplantation: a randomized controlled trial. Journal of Pain and Symptom Management, 38(2), 174-90. https://doi.org/10.1016/j.jpainsymman.2008.09.005

Vancouver

Jarden M, Nelausen K, Hovgaard D, Boesen E, Adamsen L. The effect of a multimodal intervention on treatment-related symptoms in patients undergoing hematopoietic stem cell transplantation: a randomized controlled trial. Journal of Pain and Symptom Management. 2009;38(2):174-90. https://doi.org/10.1016/j.jpainsymman.2008.09.005

Author

Jarden, Mary ; Nelausen, Knud ; Hovgaard, Doris ; Boesen, Ellen ; Adamsen, Lis. / The effect of a multimodal intervention on treatment-related symptoms in patients undergoing hematopoietic stem cell transplantation: a randomized controlled trial. In: Journal of Pain and Symptom Management. 2009 ; Vol. 38, No. 2. pp. 174-90.

Bibtex

@article{17c9b58068c711df928f000ea68e967b,
title = "The effect of a multimodal intervention on treatment-related symptoms in patients undergoing hematopoietic stem cell transplantation: a randomized controlled trial",
abstract = "Studies applying exercise, relaxation training, and psychoeducation have each indicated a positive impact on physical performance and/or psychological factors in patients diagnosed with cancer. We explored the longitudinal effect of a combination of these interventions on treatment-related symptoms in patients undergoing myeloablative allogeneic hematopoietic stem cell transplantation (allo-HSCT). Forty-two patients (18-65 years) were randomized either to an intervention or a control group. The intervention group received standard treatment and care, and a supervised four- to six-week structured exercise program, progressive relaxation, and psychoeducation during hospitalization, one hour per day for five days per week. The control group received standard treatment, care, and physiotherapy. A 24-item symptom assessment questionnaire was completed weekly during hospitalization, and at three and six months after allo-HCST. Through principal component analysis with varimax rotation, individual symptoms were grouped into five symptom clusters: mucositis, cognitive, gastrointestinal, affective, and functional symptom clusters. Then, a subsequent general estimate equation analysis revealed similar longitudinal patterns of intensity in all symptom clusters for intervention and control groups, but in the intervention group, there was an overall significant reduction (P<0.05) in symptom intensity over time for all clusters except the affective symptom cluster. This study provides beginning evidence for the efficacy of an exercise-based multimodal intervention in reducing the intensity of a spectrum of symptoms in this small sample of patients undergoing allo-HSCT.",
author = "Mary Jarden and Knud Nelausen and Doris Hovgaard and Ellen Boesen and Lis Adamsen",
note = "Keywords: Adolescent; Adult; Aged; Combined Modality Therapy; Female; Hematopoietic Stem Cell Transplantation; Humans; Karnofsky Performance Status; Male; Middle Aged; Prospective Studies; Young Adult",
year = "2009",
doi = "10.1016/j.jpainsymman.2008.09.005",
language = "English",
volume = "38",
pages = "174--90",
journal = "Journal of Pain and Symptom Management",
issn = "0885-3924",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - The effect of a multimodal intervention on treatment-related symptoms in patients undergoing hematopoietic stem cell transplantation: a randomized controlled trial

AU - Jarden, Mary

AU - Nelausen, Knud

AU - Hovgaard, Doris

AU - Boesen, Ellen

AU - Adamsen, Lis

N1 - Keywords: Adolescent; Adult; Aged; Combined Modality Therapy; Female; Hematopoietic Stem Cell Transplantation; Humans; Karnofsky Performance Status; Male; Middle Aged; Prospective Studies; Young Adult

PY - 2009

Y1 - 2009

N2 - Studies applying exercise, relaxation training, and psychoeducation have each indicated a positive impact on physical performance and/or psychological factors in patients diagnosed with cancer. We explored the longitudinal effect of a combination of these interventions on treatment-related symptoms in patients undergoing myeloablative allogeneic hematopoietic stem cell transplantation (allo-HSCT). Forty-two patients (18-65 years) were randomized either to an intervention or a control group. The intervention group received standard treatment and care, and a supervised four- to six-week structured exercise program, progressive relaxation, and psychoeducation during hospitalization, one hour per day for five days per week. The control group received standard treatment, care, and physiotherapy. A 24-item symptom assessment questionnaire was completed weekly during hospitalization, and at three and six months after allo-HCST. Through principal component analysis with varimax rotation, individual symptoms were grouped into five symptom clusters: mucositis, cognitive, gastrointestinal, affective, and functional symptom clusters. Then, a subsequent general estimate equation analysis revealed similar longitudinal patterns of intensity in all symptom clusters for intervention and control groups, but in the intervention group, there was an overall significant reduction (P<0.05) in symptom intensity over time for all clusters except the affective symptom cluster. This study provides beginning evidence for the efficacy of an exercise-based multimodal intervention in reducing the intensity of a spectrum of symptoms in this small sample of patients undergoing allo-HSCT.

AB - Studies applying exercise, relaxation training, and psychoeducation have each indicated a positive impact on physical performance and/or psychological factors in patients diagnosed with cancer. We explored the longitudinal effect of a combination of these interventions on treatment-related symptoms in patients undergoing myeloablative allogeneic hematopoietic stem cell transplantation (allo-HSCT). Forty-two patients (18-65 years) were randomized either to an intervention or a control group. The intervention group received standard treatment and care, and a supervised four- to six-week structured exercise program, progressive relaxation, and psychoeducation during hospitalization, one hour per day for five days per week. The control group received standard treatment, care, and physiotherapy. A 24-item symptom assessment questionnaire was completed weekly during hospitalization, and at three and six months after allo-HCST. Through principal component analysis with varimax rotation, individual symptoms were grouped into five symptom clusters: mucositis, cognitive, gastrointestinal, affective, and functional symptom clusters. Then, a subsequent general estimate equation analysis revealed similar longitudinal patterns of intensity in all symptom clusters for intervention and control groups, but in the intervention group, there was an overall significant reduction (P<0.05) in symptom intensity over time for all clusters except the affective symptom cluster. This study provides beginning evidence for the efficacy of an exercise-based multimodal intervention in reducing the intensity of a spectrum of symptoms in this small sample of patients undergoing allo-HSCT.

U2 - 10.1016/j.jpainsymman.2008.09.005

DO - 10.1016/j.jpainsymman.2008.09.005

M3 - Journal article

VL - 38

SP - 174

EP - 190

JO - Journal of Pain and Symptom Management

JF - Journal of Pain and Symptom Management

SN - 0885-3924

IS - 2

ER -

ID: 19979282