The influence of anti-inflammatory medication on exercise-induced myogenic precursor cell responses in humans

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

The influence of anti-inflammatory medication on exercise-induced myogenic precursor cell responses in humans. / Mackey, Abigail; Kjaer, Michael; Dandanell, Sune; Mikkelsen, Kristian H; Holm, Lars; Døssing, Simon; Kadi, Fawzi; Koskinen, Satu O; Jensen, Charlotte H; Schrøder, Henrik D; Langberg, Henning.

In: Journal of Applied Physiology, Vol. 103, No. 2, 2007, p. 425-31.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Mackey, A, Kjaer, M, Dandanell, S, Mikkelsen, KH, Holm, L, Døssing, S, Kadi, F, Koskinen, SO, Jensen, CH, Schrøder, HD & Langberg, H 2007, 'The influence of anti-inflammatory medication on exercise-induced myogenic precursor cell responses in humans', Journal of Applied Physiology, vol. 103, no. 2, pp. 425-31. https://doi.org/10.1152/japplphysiol.00157.2007

APA

Mackey, A., Kjaer, M., Dandanell, S., Mikkelsen, K. H., Holm, L., Døssing, S., ... Langberg, H. (2007). The influence of anti-inflammatory medication on exercise-induced myogenic precursor cell responses in humans. Journal of Applied Physiology, 103(2), 425-31. https://doi.org/10.1152/japplphysiol.00157.2007

Vancouver

Mackey A, Kjaer M, Dandanell S, Mikkelsen KH, Holm L, Døssing S et al. The influence of anti-inflammatory medication on exercise-induced myogenic precursor cell responses in humans. Journal of Applied Physiology. 2007;103(2):425-31. https://doi.org/10.1152/japplphysiol.00157.2007

Author

Mackey, Abigail ; Kjaer, Michael ; Dandanell, Sune ; Mikkelsen, Kristian H ; Holm, Lars ; Døssing, Simon ; Kadi, Fawzi ; Koskinen, Satu O ; Jensen, Charlotte H ; Schrøder, Henrik D ; Langberg, Henning. / The influence of anti-inflammatory medication on exercise-induced myogenic precursor cell responses in humans. In: Journal of Applied Physiology. 2007 ; Vol. 103, No. 2. pp. 425-31.

Bibtex

@article{a2b212d0dcc911de974b000ea68e967b,
title = "The influence of anti-inflammatory medication on exercise-induced myogenic precursor cell responses in humans",
abstract = "The consumption of nonsteroidal anti-inflammatory drugs (NSAIDs) is widespread among athletes when faced with muscle soreness or injury, but the effects of NSAIDs on satellite cell activity in humans are unknown. To investigate this, 14 healthy male endurance athletes (mean peak oxygen consumption 62 ml x kg(-1) x min(-1)) volunteered for the study, which involved running 36 km. They were divided into two groups and received either 100 mg indomethacin per day or placebo. Muscle biopsies collected before the run and on days 1, 3, and 8 afterward were analyzed for satellite cells by immunohistochemistry with the aid of neural cell adhesion molecule (NCAM) and fetal antigen-1 (FA1) antibodies. Muscle biopsies were also collected from untrained individuals for comparison. Compared with preexercise levels, a 27{\%} increase in the number of NCAM+ cells was observed on day 8 postexercise in the placebo group (P < 0.05), while levels remained similar at all time points in the NSAID group. No change was seen in the proportion of FA1+ cells, although lower levels were found in the muscle of endurance-trained athletes compared with untrained individuals (P < 0.05). These results suggest that ingestion of anti-inflammatory drugs attenuates the exercise-induced increase in satellite cell number, supporting the role of the cyclooxygenase pathway in satellite cell activity.",
author = "Abigail Mackey and Michael Kjaer and Sune Dandanell and Mikkelsen, {Kristian H} and Lars Holm and Simon D{\o}ssing and Fawzi Kadi and Koskinen, {Satu O} and Jensen, {Charlotte H} and Schr{\o}der, {Henrik D} and Henning Langberg",
note = "Keywords: Adult; Anti-Inflammatory Agents, Non-Steroidal; Biological Markers; Biopsy; Cell Proliferation; Cyclooxygenase Inhibitors; Exercise; Female; Humans; Indomethacin; Intercellular Signaling Peptides and Proteins; Male; Membrane Proteins; Muscle, Skeletal; Neural Cell Adhesion Molecules; Prostaglandin-Endoperoxide Synthases; Regeneration; Running; Satellite Cells, Skeletal Muscle",
year = "2007",
doi = "10.1152/japplphysiol.00157.2007",
language = "English",
volume = "103",
pages = "425--31",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "2",

}

RIS

TY - JOUR

T1 - The influence of anti-inflammatory medication on exercise-induced myogenic precursor cell responses in humans

AU - Mackey, Abigail

AU - Kjaer, Michael

AU - Dandanell, Sune

AU - Mikkelsen, Kristian H

AU - Holm, Lars

AU - Døssing, Simon

AU - Kadi, Fawzi

AU - Koskinen, Satu O

AU - Jensen, Charlotte H

AU - Schrøder, Henrik D

AU - Langberg, Henning

N1 - Keywords: Adult; Anti-Inflammatory Agents, Non-Steroidal; Biological Markers; Biopsy; Cell Proliferation; Cyclooxygenase Inhibitors; Exercise; Female; Humans; Indomethacin; Intercellular Signaling Peptides and Proteins; Male; Membrane Proteins; Muscle, Skeletal; Neural Cell Adhesion Molecules; Prostaglandin-Endoperoxide Synthases; Regeneration; Running; Satellite Cells, Skeletal Muscle

PY - 2007

Y1 - 2007

N2 - The consumption of nonsteroidal anti-inflammatory drugs (NSAIDs) is widespread among athletes when faced with muscle soreness or injury, but the effects of NSAIDs on satellite cell activity in humans are unknown. To investigate this, 14 healthy male endurance athletes (mean peak oxygen consumption 62 ml x kg(-1) x min(-1)) volunteered for the study, which involved running 36 km. They were divided into two groups and received either 100 mg indomethacin per day or placebo. Muscle biopsies collected before the run and on days 1, 3, and 8 afterward were analyzed for satellite cells by immunohistochemistry with the aid of neural cell adhesion molecule (NCAM) and fetal antigen-1 (FA1) antibodies. Muscle biopsies were also collected from untrained individuals for comparison. Compared with preexercise levels, a 27% increase in the number of NCAM+ cells was observed on day 8 postexercise in the placebo group (P < 0.05), while levels remained similar at all time points in the NSAID group. No change was seen in the proportion of FA1+ cells, although lower levels were found in the muscle of endurance-trained athletes compared with untrained individuals (P < 0.05). These results suggest that ingestion of anti-inflammatory drugs attenuates the exercise-induced increase in satellite cell number, supporting the role of the cyclooxygenase pathway in satellite cell activity.

AB - The consumption of nonsteroidal anti-inflammatory drugs (NSAIDs) is widespread among athletes when faced with muscle soreness or injury, but the effects of NSAIDs on satellite cell activity in humans are unknown. To investigate this, 14 healthy male endurance athletes (mean peak oxygen consumption 62 ml x kg(-1) x min(-1)) volunteered for the study, which involved running 36 km. They were divided into two groups and received either 100 mg indomethacin per day or placebo. Muscle biopsies collected before the run and on days 1, 3, and 8 afterward were analyzed for satellite cells by immunohistochemistry with the aid of neural cell adhesion molecule (NCAM) and fetal antigen-1 (FA1) antibodies. Muscle biopsies were also collected from untrained individuals for comparison. Compared with preexercise levels, a 27% increase in the number of NCAM+ cells was observed on day 8 postexercise in the placebo group (P < 0.05), while levels remained similar at all time points in the NSAID group. No change was seen in the proportion of FA1+ cells, although lower levels were found in the muscle of endurance-trained athletes compared with untrained individuals (P < 0.05). These results suggest that ingestion of anti-inflammatory drugs attenuates the exercise-induced increase in satellite cell number, supporting the role of the cyclooxygenase pathway in satellite cell activity.

U2 - 10.1152/japplphysiol.00157.2007

DO - 10.1152/japplphysiol.00157.2007

M3 - Journal article

C2 - 17463304

VL - 103

SP - 425

EP - 431

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 2

ER -

ID: 16083905