Jørgen Hilden

Jørgen Hilden

Associate professor emeritus, Associate Professor emeritus

Member of:


    1. 2021
    2. Published

      A screening method to spot biomarkers that may warn of serious events in a chronic disease - illustrated by cardiological CLARICOR trial data

      Winkel, P., Hilden, Jørgen, Jakobsen, J. C., Lindschou, J., Jensen, G. B., Kjøller, E., Sajadieh, Ahmad, Kastrup, J., Kolmos, H. J., Larsson, A., Arnlov, J., Bjerre, M. & Gluud, C., 2021, In: Clinical Chemistry and Laboratory Medicine. 59, 11, p. 1852-1860 9 p.

      Research output: Contribution to journalJournal articlepeer-review

    3. Published

      Trajectories in severe persistent pain after groin hernia repair: A retrospective analysis

      Jensen, E. K., Bäckryd, E., Hilden, Jørgen & Werner, M. U., 2021, In: Scandinavian Journal of Pain. 21, 1, p. 70-80 11 p.

      Research output: Contribution to journalJournal articlepeer-review

    4. 2020
    5. Published

      Prognosis and Reclassification by YKL-40 in Stable Coronary Artery Disease

      Schroder, J., Jakobsen, J. C., Winkel, P., Hilden, Jørgen, Jensen, G. B., Sajadieh, Ahmad, Larsson, A., Ärnlöv, J., Harutyunyan, M., Johansen, Julia Sidenius, Kjøller, E., Gluud, C. & Kastrup, J., 2020, In: Journal of the American Heart Association. 9, 5, e01463.

      Research output: Contribution to journalJournal articlepeer-review

    6. Published

      Prognostic value of 12 novel cardiological biomarkers in stable coronary artery disease: A 10-year follow-up of the placebo group of the Copenhagen CLARICOR trial

      Winkel, P., Jakobsen, J. C., Hilden, Jørgen, Jensen, G. B., Kjøller, E., Sajadieh, Ahmad, Kastrup, J., Kolmos, H. J., Iversen, Kasper, Bjerre, M., Larsson, A., Ärnlöv, J. & Gluud, C., 2020, In: BMJ Open. 10, 8, 7 p., e033720.

      Research output: Contribution to journalJournal articlepeer-review

    7. Published

      Serum osteoprotegerin as a long-term predictor for patients with stable coronary artery disease and its association with diabetes and statin treatment: A CLARICOR trial 10-year follow-up substudy

      Bjerre, M., Hilden, Jørgen, Winkel, P., Jensen, G. B., Kjøller, E., Sajadieh, Ahmad, Kastrup, J., Kolmos, H. J., Larsson, A., Arnlov, J., Jakobsen, J. C. & Gluud, C., 2020, In: Atherosclerosis. 301, p. 8-14 7 p.

      Research output: Contribution to journalJournal articlepeer-review

    8. 2019
    9. Published

      Circulating endostatin as a risk factor for cardiovascular events in patients with stable coronary heart disease: A CLARICOR trial sub-study

      Ruge, T., Carlsson, A. C., Kjøller, E., Hilden, Jørgen, Kolmos, H. J., Sajadieh, Ahmad, Kastrup, J., Jensen, G. B., Larsson, A., Nowak, C., Jakobsen, J. C., Winkel, P., Gluud, C. & Arnlov, J., 2019, In: Atherosclerosis. 284, p. 202-208 7 p.

      Research output: Contribution to journalJournal articlepeer-review

    10. Published

      Power estimations for non-primary outcomes in randomised clinical trials

      Jakobsen, J. C., Ovesen, C., Winkel, P., Hilden, Jørgen, Gluud, C. & Wetterslev, J., 2019, In: BMJ Open. 9, 6, 3 p., e027092.

      Research output: Contribution to journalJournal articlepeer-review

    11. 2018
    12. Published

      10-Year Associations Between Tumor Necrosis Factor Receptors 1 and 2 and Cardiovascular Events in Patients With Stable Coronary Heart Disease: A CLARICOR (Effect of Clarithromycin on Mortality and Morbidity in Patients With Ischemic Heart Disease) Trial Substudy

      Carlsson, A. C., Ruge, T., Kjøller, E., Hilden, Jørgen, Kolmos, H. J., Sajadieh, Ahmad, Kastrup, J., Jensen, G. B., Larsson, A., Nowak, C., Jakobsen, J. C., Winkel, P., Gluud, C. & Ärnlöv, J., 1 May 2018, In: Journal of the American Heart Association. 7, 9, 11 p., e008299.

      Research output: Contribution to journalJournal articlepeer-review

    13. Published

      Cathepsin B and S as markers for cardiovascular risk and all-cause mortality in patients with stable coronary heart disease during 10 years: a CLARICOR trial sub-study

      Wuopio, J., Hilden, Jørgen, Bring, C., Kastrup, J., Sajadieh, Ahmad, Jensen, G. B., Kjøller, E., Kolmos, H. J., Larsson, A., Jakobsen, J. C., Winkel, P., Gluud, C., Carlsson, A. C. & Ärnlöv, J., 2018, In: Atherosclerosis. 278, p. 97-102 6 p.

      Research output: Contribution to journalJournal articlepeer-review

    14. Published

      Minimum clinically important differences in chronic pain vary considerable by baseline pain and methodological factors: systematic review of empirical studies

      Olsen, Mette Frahm, Bjerre, E., Hansen, M. D., Tendal, B., Hilden, Jørgen & Hróbjartsson, A., 2018, In: Journal of Clinical Epidemiology. 101, p. 87-106.e2 22 p.

      Research output: Contribution to journalReviewpeer-review

    15. Published

      Prognostic value of routinely available data in patients with stable coronary heart disease. A 10-year follow-up of patients sampled at random times during their disease course

      Winkel, P., Jakobsen, J. C., Hilden, Jørgen, Jensen, G., Kjøller, E., Sajadieh, Ahmad, Kastrup, J., Kolmos, H. J., Larsson, A., Arnlov, J. & Gluud, C., 2018, In: Open Heart. 5, 2, 10 p., e000808.

      Research output: Contribution to journalJournal articlepeer-review

    16. 2017
    17. Published

      Pain relief that matters to patients: systematic review of empirical studies assessing the minimum clinically important difference in acute pain

      Olsen, Mette Frahm, Bjerre, E., Hansen, M. D., Hilden, Jørgen, Landler, N. E., Tendal, B. & Hróbjartsson, A., 2017, In: B M C Medicine. 15, 18 p., 35.

      Research output: Contribution to journalReviewpeer-review

    18. Published

      Predictors for major cardiovascular outcomes in stable ischaemic heart disease (PREMAC): statistical analysis plan for data originating from the CLARICOR (clarithromycin for patients with stable coronary heart disease) trial

      Winkel, P., Jakobsen, J. C., Hilden, Jørgen, Lange, Theis, Jensen, G. B., Kjøller, E., Sajadieh, Ahmad, Kastrup, J., Kolmos, H. J., Larsson, A., Ärnlöv, J. & Gluud, C., 2017, In: Diagnostic and Prognostic Research. 1, 8 p., 10.

      Research output: Contribution to journalJournal articlepeer-review

    19. 2016
    20. Published

      Early-Phase Studies of Biomarkers: What Target Sensitivity and Specificity Values Might Confer Clinical Utility?

      Pepe, M. S., Janes, H., Li, C. I., Bossuyt, P. M., Feng, Z. & Hilden, Jørgen, May 2016, In: Clinical Chemistry. 62, 5, p. 737-742 6 p.

      Research output: Contribution to journalJournal articlepeer-review

    21. Published

      The matching quality of experimental and control interventions in blinded pharmacological randomised clinical trials: a methodological systematic review

      Bello, S., Wei, M., Hilden, Jørgen & Hróbjartsson, A., 13 Feb 2016, In: BMC Medical Research Methodology. 16, p. 1-12 12 p., 18.

      Research output: Contribution to journalReviewpeer-review

    22. 2015
    23. Published

      The Net Reclassification Index (NRI): A Misleading Measure of Prediction Improvement Even with Independent Test Data Sets

      Pepe, M. S., Fan, J., Feng, Z., Gerds, Thomas Alexander & Hilden, Jørgen, Oct 2015, In: Statistics in BioSciences. 7, 2, p. 282-295 14 p.

      Research output: Contribution to journalJournal articlepeer-review

    24. Published

      Clarithromycin for stable coronary heart disease increases all-cause and cardiovascular mortality and cerebrovascular morbidity over 10years in the CLARICOR randomised, blinded clinical trial

      Winkel, P., Hilden, Jørgen, Hansen, J. F., Kastrup, J., Kolmos, H. J., Kjøller, E., Boje Jensen, G., Skoog, M., Lindschou, J., Gluud, C. & CLARICOR Trial Group, C. T. G., Mar 2015, In: International Journal of Cardiology. 182, p. 459-65 7 p.

      Research output: Contribution to journalJournal articlepeer-review

    25. 2014
    26. Published

      Osteoprotegerin independently predicts mortality in patients with stable coronary artery disease: The CLARICOR trial

      Bjerre, M., Hilden, Jørgen, Kastrup, J., Skoog, M., Hansen, J. F., Kolmos, H. J., Jensen, G. B., Kjøller, E., Winkel, P., Flyvbjerg, A., Gluud, C. & CLARICOR Trial Group, C. T. G., Nov 2014, In: Scandinavian Journal of Clinical & Laboratory Investigation. 74, 8, p. 657-664 8 p.

      Research output: Contribution to journalJournal articlepeer-review

    27. Published

      A note on the evaluation of novel biomarkers: do not rely on integrated discrimination improvement and net reclassification index

      Hilden, Jørgen & Gerds, Thomas Alexander, 30 Aug 2014, In: Statistics in Medicine. 33, 19, p. 3405-14 10 p.

      Research output: Contribution to journalJournal articlepeer-review

    28. Published

      Calibration of models is not sufficient to justify NRI

      Gerds, Thomas Alexander & Hilden, Jørgen, 30 Aug 2014, In: Statistics in Medicine. 33, 19, p. 3419-20 2 p.

      Research output: Contribution to journalComment/debatepeer-review

    29. Published

      Agreement between public register and adjudication committee outcome in a cardiovascular randomized clinical trial

      Kjøller, E., Hilden, Jørgen, Winkel, P., Galatius, S., Frandsen, N. J., Jensen, G. B., Fischer Hansen, J., Kastrup, J., Jespersen, C. M., Hildebrandt, P., Kolmos, H. J., Gluud, C. & CLARICOR Trial Group, C. T. G., Aug 2014, In: American Heart Journal. 168, 2, p. 197–204.e4 12 p.

      Research output: Contribution to journalJournal articlepeer-review

    30. Published

      Bias due to lack of patient blinding in clinical trials: A systematic review of trials randomizing patients to blind and nonblind sub-studies

      Hróbjartsson, A., Emanuelsson, F., Skou Thomsen, A. S., Hilden, Jørgen & Brorson, Stig, Aug 2014, In: International Journal of Epidemiology. 43, 4, p. 1272-1283 12 p.

      Research output: Contribution to journalJournal articlepeer-review

    31. Published

      Observer bias in randomized clinical trials with time-to-event outcomes: systematic review of trials with both blinded and non-blinded outcome assessors

      Hróbjartsson, A., Thomsen, A. S. S., Emanuelsson, F., Tendal, B., Rasmussen, J. V., Hilden, Jørgen, Boutron, I., Ravaud, P. & Brorson, Stig, Jun 2014, In: International Journal of Epidemiology. 43, 3, p. 937-948 12 p.

      Research output: Contribution to journalJournal articlepeer-review

    32. Published

      On NRI, IDI, and "good-looking" statistics with nothing underneath

      Hilden, Jørgen, Mar 2014, In: Epidemiology (Cambridge, Mass.). 25, 2, p. 265-7 3 p.

      Research output: Contribution to journalComment/debatepeer-review

    33. Published

      Risk stratification in stable coronary artery disease is possible at cardiac troponin levels below conventional detection and is improved by use of N-terminal pro-B-type natriuretic peptide

      Lyngbæk, S., Winkel, P., Gøtze, J. P., Kastrup, J., Gluud, C., Kolmos, H. J., Kjøller, E., Jensen, G. B., Hansen, J. F., Hildebrandt, P., Hilden, Jørgen & CLARICOR Trial Group, C. T. G., 2014, In: European Journal of Preventive Cardiology. 21, 10, p. 1275-1284 10 p.

      Research output: Contribution to journalJournal articlepeer-review

    34. 2013
    35. Published

      Serum YKL-40 predicts long-term mortality in patients with stable coronary disease: a prognostic study within the CLARICOR trial

      Harutyunyan, M., Goetze, Jens P. , Winkel, P., Johansen, Julia Sidenius, Hansen, J. F., Jensen, G. B., Hilden, Jørgen, Kjøller, E., Kolmos, H. J., Gluud, C. & Kastrup, J., Jul 2013, In: Immunobiology. 218, 7, p. 945-51 7 p.

      Research output: Contribution to journalJournal articlepeer-review

    36. Published

      Observer bias in randomized clinical trials with measurement scale outcomes: a systematic review of trials with both blinded and nonblinded assessors

      Hróbjartsson, A., Thomsen, A. S. S., Emanuelsson, F., Tendal, B., Hilden, Jørgen, Boutron, I., Ravaud, P. & Brorson, Stig, 5 Mar 2013, In: C M A J. 185, 4, p. E201-11

      Research output: Contribution to journalJournal articlepeer-review

    37. 2012
    38. Published

      Observer bias in randomised clinical trials with binary outcomes: systematic review of trials with both blinded and non-blinded outcome assessors

      Hróbjartsson, A., Thomsen, A. S. S., Emanuelsson, F., Tendal, B., Hilden, Jørgen, Boutron, I., Ravaud, P. & Brorson, Stig, 27 Feb 2012, In: B M J (Online). 344, p. e1119

      Research output: Contribution to journalJournal articlepeer-review

    39. Published

      Observer bias in randomised clinical trials with binary outcomes: systematic review of trials with both blinded and non-blinded outcome assessors

      Hróbjartsson, A., Thomsen, A. S. S., Emanuelsson, F., Tendal, B., Hilden, Jørgen, Boutron, I., Ravaud, P. & Brorson, S., 27 Feb 2012, In: B M J (Clinical Research Edition). 344, 1 p., e1119.

      Research output: Contribution to journalJournal articlepeer-review

    40. Published

      Good interobserver agreement was attainable on outcome adjudication in patients with stable coronary heart disease

      Kjoller, E., Hilden, Jørgen, Winkel, P., Frandsen, N. J., Galatius, S., Jensen, G., Kastrup, J., Hansen, J. F., Kolmos, H. J. J., Jespersen, C. M., Hildebrandt, P., Gluud, C. N. & CLARICOR Trial Group, C. T. G., 2012, In: Journal of Clinical Epidemiology. 65, 4, p. 444-53 10 p.

      Research output: Contribution to journalJournal articlepeer-review

    41. 2011
    42. Published

      High-sensitivity C-reactive protein and N-terminal pro-B-type natriuretic peptide in patients with stable coronary artery disease: a prognostic study within the CLARICOR Trial

      Harutyunyan, M. J., Mathiasen, A. B., Winkel, P., Goetze, Jens P. , Hansen, J. F., Hildebrandt, P., Jensen, G. B., Hilden, Jørgen, Jespersen, C. M., Kjøller, E., Kolmos, H. J., Gluud, C., Kastrup, J. & CLARICOR Trial Group, C. T. G., 1 Feb 2011, In: Scandinavian Journal of Clinical & Laboratory Investigation. 71, 1, p. 52-62 11 p.

      Research output: Contribution to journalJournal articlepeer-review

    43. Published

      Pregnancy associated plasma protein-A as a marker for myocardial infarction and death in patients with stable coronary artery disease: A prognostic study within the CLARICOR Trial

      Iversen, Kasper, Teisner, B., Winkel, P., Gluud, C., Kjøller, E., Kolmos, H. J., Hildebrandt, P. R., Hilden, Jørgen, Kastrup, J. & The CLARICOR Trial Group, T. C. T. G., 1 Jan 2011, In: Atherosclerosis. 214, 1, p. 203-208 6 p.

      Research output: Contribution to journalJournal articlepeer-review

    44. Published

      Assessment of the diagnostic accuracy of laboratory tests using receiver operating characteristic curves; approved guideline - second edition

      Kroll, M., Biswas, B., Budd, J., Durham, P., Gorman, R., Gwise, T., Halim, A., Hatjimihail, A., Hilden, Jørgen & Kyunghee, S., 2011, In: Clinical and Laboratory Standards Institute Document. 31, 23, p. 1-45 45 p.

      Research output: Contribution to journalJournal articlepeer-review

    45. Published

      Excess sudden cardiac deaths after short-term clarithromycin administration in the CLARICOR trial: why is this so, and why are statins protective?

      Winkel, P., Hilden, Jørgen, Hansen, J. F., Hildebrandt, P., Kastrup, J., Kolmos, H. J., Kjøller, E., Jespersen, C. M., Gluud, C., Jensen, G. & CLARICOR Trial, G., 2011, In: Cardiology. 118, 1, p. 63-67

      Research output: Contribution to journalJournal articlepeer-review

    46. 2010
    47. Published

      Statin treatment prevents increased cardiovascular and all-cause mortality associated with clarithromycin in patients with stable coronary heart disease

      Jensen, G. B., Hilden, J., Als-Nielsen, B., Damgaard, M., Hansen, J. F., Hansen, S., Helø, O. H., Hildebrandt, P., Kastrup, J., Kolmos, H. J., Kjøller, E., Lind, I., Nielsen, H., Petersen, L., Jespersen, C. M., Gluud, C., CLARICOR Trial Group, Jensen, G. B., Hilden, J., Als-Nielsen, B. & 14 others, Damgaard, M., Hansen, J. F., Hansen, S., Helø, O. H., Hildebrandt, P., Kastrup, J., Kolmos, H. J., Kjøller, E., Lind, I., Nielsen, H., Petersen, L., Jespersen, C., Gluud, C. & CLARICOR Trial Group, C. T. G., 1 Feb 2010, In: Journal of Cardiovascular Pharmacology. 55, 2, p. 123-8 6 p.

      Research output: Contribution to journalJournal articlepeer-review

    48. Published

      Simultaneous use of serum IgG and IgM for risk scoring of suspected early Lyme borreliosis: graphical and bivariate analyses

      Dessau, R. B., Ejlertsen, T. & Hilden, Jørgen, 2010, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 118, 4, p. 313-23 11 p.

      Research output: Contribution to journalJournal articlepeer-review

    49. 2009
    50. Published

      Betydning af opholdstid og antal flytninger på asylbørns psykiske helbred - sekundærpublikation

      Jervelund, Signe Smith, Nørredam, Marie Louise, Christiansen, K. L., Obel, C., Hilden, Jørgen & Krasnik, Allan, 2009, In: Ugeskrift for læger. 171, 12, p. 981-4 3 p.

      Research output: Contribution to journalJournal articlepeer-review

    51. Published

      Bias in Scientific Studies

      Hilden, Jørgen, 2009, Encyclopedia Of Medical Decision Making. Kattan, M. (ed.). USA: SAGE Publications, p. 80-85 6 p.

      Research output: Chapter in Book/Report/Conference proceedingEncyclopedia chapterResearch

    52. Published

      Boolean Algebra and Nodes

      Hilden, Jørgen, 2009, Encyclopedia Of Medical Decision Making. Kattan, M. W. (ed.). USA: SAGE Publications, p. 94-98 5 p.

      Research output: Chapter in Book/Report/Conference proceedingEncyclopedia chapterCommunication

    53. Published

      Compliance with and short-term adverse events from clarithromycin versus placebo in patients with stable coronary heart disease: the CLARICOR trial

      Jespersen, C. M., Kolmos, H. J., Frydendall, N., Hilden, Jørgen, Gluud, C., Hansen, J. F. & CLARICOR Trial Group, C. T. G., 2009, In: Journal of Antimicrobial Chemotherapy. 64, 2, p. 411-5 4 p.

      Research output: Contribution to journalJournal articlepeer-review

    54. Published

      Expected Value of Sample Information

      Hilden, Jørgen, 2009, Expected Value of Sample Information: Net Benefit of Sampling. USA: SAGE Publications, p. 481-86 6 p.

      Research output: Chapter in Book/Report/Conference proceedingEncyclopedia chapterCommunication

    55. Published

      Povl Heiberg's 1897 methodological study on the statistical method as an aid in therapeutic trials

      Gluud, C. & Hilden, Jørgen, 2009, In: Preventive Medicine. 48, 6, p. 600-3 3 p.

      Research output: Contribution to journalJournal articlepeer-review

    56. 2008
    57. Published

      Budget impact analysis and its rational basis

      Hilden, Jørgen, 2008, In: Medical Decision Making. 28, 4, p. 460-1 1 p.

      Research output: Contribution to journalJournal articlepeer-review

    58. Published

      Clarithromycin for 2 Weeks for Stable Coronary Heart Disease: 6-Year Follow-Up of the CLARICOR Randomized Trial and Updated Meta-Analysis of Antibiotics for Coronary Heart Disease.

      Gluud, C., Als-Nielsen, B., Damgaard, M., Fischer Hansen, J., Hansen, S., Helø, O. H., Hildebrandt, P., Hilden, J., Jensen, G. B., Kastrup, J., Kolmos, H. J., Kjøller, E., Lind, I., Nielsen, H., Petersen, L., Jespersen, C. M., CLARICOR Trial Group, Gluud, C., Als-Nielsen, B., Damgaard, M. & 13 others, Fischer Hansen, J., Hansen, S. H. S., Helø, O. H., Hildebrandt, P., Hilden, J., Jensen, G. B., Kastrup, J., Kolmos, H. J., Kjøller, E., Lind, I., Nielsen, H., Petersen, L. & Jespersen, C. M., 2008, In: Cardiology. 111, 4, p. 280-287 7 p.

      Research output: Contribution to journalJournal articlepeer-review

    59. Published

      Impact of allocation concealment on conclusions drawn from meta-analyses of randomized trials (vol 36, pg 847, 2007)

      Pildal, J., Hrobjartsson, A., Jorgensen, K. J., Hilden, Jørgen, Altman, D. G. & Gotzsche, P. C., 2008, In: International Journal of Epidemiology. 37, 2, p. 422-422 1 p.

      Research output: Contribution to journalJournal articlepeer-review

    60. Published

      Mental health among children seeking asylum in Denmark--the effect of length of stay and number of relocations: a cross-sectional study

      Nørredam, Marie Louise, Nielsen, S., Christiansen, K., Obel, C., Hilden, Jørgen & Krasnik, Allan, 2008, In: BMC Public Health. 8, 293

      Research output: Contribution to journalJournal articlepeer-review

    61. Published

      More studies on outcomes using biochemical diagnostic tests are needed: findings from the Danish Society of Clinical Biochemistry

      Madsen, J. S., Nybo, M., Magid, E., Hilden, Jørgen, Hornung, N., Larsen, T. B., Jørgensen, L. & Jørgensen, P. E., 2008, In: Clinical Chemistry. 54, 7, p. 1254-6 2 p.

      Research output: Contribution to journalJournal articlepeer-review

    62. Published

      Organisational factors influencing asylum-seeking children's mental health

      Jervelund, Signe Smith, Nørredam, Marie Louise, Christiansen, K. L., Obel, C., Hilden, Jørgen & Krasnik, Allan, 2008. 1 p.

      Research output: Contribution to conferenceConference abstract for conferenceResearch

    63. Published

      Systematic reviews of diagnostic test accuracy

      Leeflang, M. M. G., Deeks, J. J., Gatsonis, C., Bossuyt, P. M. M. & Hilden, Jørgen, 2008, In: Annals of Internal Medicine. 149, 12, p. 889-97 8 p.

      Research output: Contribution to journalJournal articlepeer-review

    64. Published

      The Osteoporosis Self-Assessment Tool versus alternative tests for selecting postmenopausal women for bone mineral density assessment: a comparative systematic review of accuracy

      Rud, B., Hilden, Jørgen, Hyldstrup, L. & Hróbjartsson, A., 2008, In: Osteoporosis International.

      Research output: Contribution to journalJournal articlepeer-review

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