2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans
Research output: Contribution to journal › Journal article
Dietary fat is thought to stimulate release of incretin hormones via activation of fatty acid receptors in the intestine. However, dietary fat (triacylglycerol) is digested to 2-monoacylglycerol and fatty acids. Activation of G protein-coupled receptor 119 (GPR119) stimulates glucagon-like peptide-1 (GLP-1) release from the intestinal L-cells. We aimed to investigate if 2-oleoyl glycerol (2OG) can activate GPR119 in vitro and stimulate GLP-1 secretion in vivo.
|Journal||Journal of Clinical Endocrinology and Metabolism|
|Publication status||Published - 2011|
- Adult, Blood Glucose, Cyclic AMP, Enteroendocrine Cells, Glucagon-Like Peptide 1, Glycerides, Humans, Male, Oleic Acids, Receptors, G-Protein-Coupled
- Former Faculty of Pharmaceutical Sciences