A high activity level is required for augmented muscle capillarization in older women

Research output: Contribution to journalJournal articlepeer-review

Standard

A high activity level is required for augmented muscle capillarization in older women. / Gliemann, Lasse; Rytter, Nicolai; Yujia, Liu; Tamariz-Ellemann, Andrea; Carter, Howard; Hellsten, Ylva.

In: Medicine and Science in Sports and Exercise, Vol. 53, No. 5, 2021, p. 894-903.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Gliemann, L, Rytter, N, Yujia, L, Tamariz-Ellemann, A, Carter, H & Hellsten, Y 2021, 'A high activity level is required for augmented muscle capillarization in older women', Medicine and Science in Sports and Exercise, vol. 53, no. 5, pp. 894-903. https://doi.org/10.1249/MSS.0000000000002566

APA

Gliemann, L., Rytter, N., Yujia, L., Tamariz-Ellemann, A., Carter, H., & Hellsten, Y. (2021). A high activity level is required for augmented muscle capillarization in older women. Medicine and Science in Sports and Exercise, 53(5), 894-903. https://doi.org/10.1249/MSS.0000000000002566

Vancouver

Gliemann L, Rytter N, Yujia L, Tamariz-Ellemann A, Carter H, Hellsten Y. A high activity level is required for augmented muscle capillarization in older women. Medicine and Science in Sports and Exercise. 2021;53(5):894-903. https://doi.org/10.1249/MSS.0000000000002566

Author

Gliemann, Lasse ; Rytter, Nicolai ; Yujia, Liu ; Tamariz-Ellemann, Andrea ; Carter, Howard ; Hellsten, Ylva. / A high activity level is required for augmented muscle capillarization in older women. In: Medicine and Science in Sports and Exercise. 2021 ; Vol. 53, No. 5. pp. 894-903.

Bibtex

@article{cd13396e46984d9a8fea23919299bcd0,
title = "A high activity level is required for augmented muscle capillarization in older women",
abstract = "Purpose: This study aimed to evaluate the influence of lifelong regular physical activity on skeletal muscle capillarization in women.Methods: Postmenopausal women, 61±4 yr old, were divided according to self-reported physical activity level over the past 20 yrs: sedentary (SED; n = 14), moderately active (MOD; n = 12), and very active (VERY; n = 15). Leg blood flow (LBF) was determined by ultrasound Doppler, and blood samples were drawn from the femoral artery and vein for calculation of leg oxygen uptake (LVO2) at rest and during one-legged knee extensor exercise. A skeletal muscle biopsy was obtained from the vastus lateralis and analyzed for capillarization and vascular endothelial growth factor (VEGF) and mitochondrial OXPHOS proteins. Platelets were isolated from venous blood and analyzed for VEGF content and effect on endothelial cell proliferation.Results: The exercise-induced rise in LBF and LVO2 was faster (P = 0.008) in VERY compared with SED and MOD. Steady-state LBF and LVO2 were lower (P < 0.04) in MOD and VERY compared with SED. Capillary-fiber ratio and capillary density were greater (P < 0.03) in VERY (1.65 ± 0.48 and 409.3 ± 57.5) compared with MOD (1.30 ± 0.19 and 365.0 ± 40.2) and SED (1.30 ± 0.30 and 356.2 ± 66.3). Skeletal muscle VEGF and OXPHOS complexes I, II, and V were ~1.6-fold and ~1.25-fold (P < 0.01) higher, respectively, in VERY compared with SED. Platelets from all groups induced an approximately nine-fold (P < 0.001) increase in endothelial cell proliferation.Conclusion: A very active lifestyle is associated with superior skeletal muscle exercise hemodynamics and greater potential for oxygen extraction concurrent with a higher skeletal muscle capillarization and mitochondrial capacity.",
keywords = "Faculty of Science, Lifelong, Menopause, Training, Vascular endothelial growth factor",
author = "Lasse Gliemann and Nicolai Rytter and Liu Yujia and Andrea Tamariz-Ellemann and Howard Carter and Ylva Hellsten",
note = "Copyright {\textcopyright} 2021 by the American College of Sports Medicine.",
year = "2021",
doi = "10.1249/MSS.0000000000002566",
language = "English",
volume = "53",
pages = "894--903",
journal = "Medicine and Science in Sports and Exercise",
issn = "0195-9131",
publisher = "Lippincott Williams & Wilkins",
number = "5",

}

RIS

TY - JOUR

T1 - A high activity level is required for augmented muscle capillarization in older women

AU - Gliemann, Lasse

AU - Rytter, Nicolai

AU - Yujia, Liu

AU - Tamariz-Ellemann, Andrea

AU - Carter, Howard

AU - Hellsten, Ylva

N1 - Copyright © 2021 by the American College of Sports Medicine.

PY - 2021

Y1 - 2021

N2 - Purpose: This study aimed to evaluate the influence of lifelong regular physical activity on skeletal muscle capillarization in women.Methods: Postmenopausal women, 61±4 yr old, were divided according to self-reported physical activity level over the past 20 yrs: sedentary (SED; n = 14), moderately active (MOD; n = 12), and very active (VERY; n = 15). Leg blood flow (LBF) was determined by ultrasound Doppler, and blood samples were drawn from the femoral artery and vein for calculation of leg oxygen uptake (LVO2) at rest and during one-legged knee extensor exercise. A skeletal muscle biopsy was obtained from the vastus lateralis and analyzed for capillarization and vascular endothelial growth factor (VEGF) and mitochondrial OXPHOS proteins. Platelets were isolated from venous blood and analyzed for VEGF content and effect on endothelial cell proliferation.Results: The exercise-induced rise in LBF and LVO2 was faster (P = 0.008) in VERY compared with SED and MOD. Steady-state LBF and LVO2 were lower (P < 0.04) in MOD and VERY compared with SED. Capillary-fiber ratio and capillary density were greater (P < 0.03) in VERY (1.65 ± 0.48 and 409.3 ± 57.5) compared with MOD (1.30 ± 0.19 and 365.0 ± 40.2) and SED (1.30 ± 0.30 and 356.2 ± 66.3). Skeletal muscle VEGF and OXPHOS complexes I, II, and V were ~1.6-fold and ~1.25-fold (P < 0.01) higher, respectively, in VERY compared with SED. Platelets from all groups induced an approximately nine-fold (P < 0.001) increase in endothelial cell proliferation.Conclusion: A very active lifestyle is associated with superior skeletal muscle exercise hemodynamics and greater potential for oxygen extraction concurrent with a higher skeletal muscle capillarization and mitochondrial capacity.

AB - Purpose: This study aimed to evaluate the influence of lifelong regular physical activity on skeletal muscle capillarization in women.Methods: Postmenopausal women, 61±4 yr old, were divided according to self-reported physical activity level over the past 20 yrs: sedentary (SED; n = 14), moderately active (MOD; n = 12), and very active (VERY; n = 15). Leg blood flow (LBF) was determined by ultrasound Doppler, and blood samples were drawn from the femoral artery and vein for calculation of leg oxygen uptake (LVO2) at rest and during one-legged knee extensor exercise. A skeletal muscle biopsy was obtained from the vastus lateralis and analyzed for capillarization and vascular endothelial growth factor (VEGF) and mitochondrial OXPHOS proteins. Platelets were isolated from venous blood and analyzed for VEGF content and effect on endothelial cell proliferation.Results: The exercise-induced rise in LBF and LVO2 was faster (P = 0.008) in VERY compared with SED and MOD. Steady-state LBF and LVO2 were lower (P < 0.04) in MOD and VERY compared with SED. Capillary-fiber ratio and capillary density were greater (P < 0.03) in VERY (1.65 ± 0.48 and 409.3 ± 57.5) compared with MOD (1.30 ± 0.19 and 365.0 ± 40.2) and SED (1.30 ± 0.30 and 356.2 ± 66.3). Skeletal muscle VEGF and OXPHOS complexes I, II, and V were ~1.6-fold and ~1.25-fold (P < 0.01) higher, respectively, in VERY compared with SED. Platelets from all groups induced an approximately nine-fold (P < 0.001) increase in endothelial cell proliferation.Conclusion: A very active lifestyle is associated with superior skeletal muscle exercise hemodynamics and greater potential for oxygen extraction concurrent with a higher skeletal muscle capillarization and mitochondrial capacity.

KW - Faculty of Science

KW - Lifelong

KW - Menopause

KW - Training

KW - Vascular endothelial growth factor

U2 - 10.1249/MSS.0000000000002566

DO - 10.1249/MSS.0000000000002566

M3 - Journal article

C2 - 33844669

VL - 53

SP - 894

EP - 903

JO - Medicine and Science in Sports and Exercise

JF - Medicine and Science in Sports and Exercise

SN - 0195-9131

IS - 5

ER -

ID: 259933957