A marginal structural model for recurrent events in the presence of time-dependent confounding: non-specific effects of vaccines on child hospitalisations
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A marginal structural model for recurrent events in the presence of time-dependent confounding : non-specific effects of vaccines on child hospitalisations. / Jensen, Aksel K. G.; Ravn, Henrik; Sørup, Signe; Andersen, Per.
In: Statistics in Medicine, Vol. 35, No. 27, 30.11.2016, p. 5051-5069.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - A marginal structural model for recurrent events in the presence of time-dependent confounding
T2 - non-specific effects of vaccines on child hospitalisations
AU - Jensen, Aksel K. G.
AU - Ravn, Henrik
AU - Sørup, Signe
AU - Andersen, Per
PY - 2016/11/30
Y1 - 2016/11/30
N2 - Using a Danish register-based study on childhood vaccination and hospitalisation as motivation, a marginal structural model for recurrent events is studied. The model addresses a number of challenges which may be seen more generally in large register-based cohort studies. One is to adjust for a time-dependent confounder when studying the effect of a time-varying exposure on a recurrent event based on an analysis in continuous time. Another is to report results via a measure which is easy to interpret and communicate even though quite elaborate treatment regimes are considered. Lastly, the implementation of continuously updated weights implies a substantial computationally demanding workload.
AB - Using a Danish register-based study on childhood vaccination and hospitalisation as motivation, a marginal structural model for recurrent events is studied. The model addresses a number of challenges which may be seen more generally in large register-based cohort studies. One is to adjust for a time-dependent confounder when studying the effect of a time-varying exposure on a recurrent event based on an analysis in continuous time. Another is to report results via a measure which is easy to interpret and communicate even though quite elaborate treatment regimes are considered. Lastly, the implementation of continuously updated weights implies a substantial computationally demanding workload.
U2 - 10.1002/sim.7060
DO - 10.1002/sim.7060
M3 - Journal article
C2 - 27582304
VL - 35
SP - 5051
EP - 5069
JO - Statistics in Medicine
JF - Statistics in Medicine
SN - 0277-6715
IS - 27
ER -
ID: 173742060