A nation-wide population-based longitudinal study on life expectancy and cause specific mortality in patients with bipolar disorder and their siblings

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A nation-wide population-based longitudinal study on life expectancy and cause specific mortality in patients with bipolar disorder and their siblings. / Kessing, Lars Vedel; Ziersen, Simon Christoffer; Andersen, Per Kragh; Vinberg, Maj.

In: Journal of Affective Disorders, Vol. 294, 2021, p. 472-476.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kessing, LV, Ziersen, SC, Andersen, PK & Vinberg, M 2021, 'A nation-wide population-based longitudinal study on life expectancy and cause specific mortality in patients with bipolar disorder and their siblings', Journal of Affective Disorders, vol. 294, pp. 472-476. https://doi.org/10.1016/j.jad.2021.07.065

APA

Kessing, L. V., Ziersen, S. C., Andersen, P. K., & Vinberg, M. (2021). A nation-wide population-based longitudinal study on life expectancy and cause specific mortality in patients with bipolar disorder and their siblings. Journal of Affective Disorders, 294, 472-476. https://doi.org/10.1016/j.jad.2021.07.065

Vancouver

Kessing LV, Ziersen SC, Andersen PK, Vinberg M. A nation-wide population-based longitudinal study on life expectancy and cause specific mortality in patients with bipolar disorder and their siblings. Journal of Affective Disorders. 2021;294:472-476. https://doi.org/10.1016/j.jad.2021.07.065

Author

Kessing, Lars Vedel ; Ziersen, Simon Christoffer ; Andersen, Per Kragh ; Vinberg, Maj. / A nation-wide population-based longitudinal study on life expectancy and cause specific mortality in patients with bipolar disorder and their siblings. In: Journal of Affective Disorders. 2021 ; Vol. 294. pp. 472-476.

Bibtex

@article{1319edcb39f34543989d2b2139edc9e6,
title = "A nation-wide population-based longitudinal study on life expectancy and cause specific mortality in patients with bipolar disorder and their siblings",
abstract = "Objective: Mortality is increased in bipolar disorder due to both suicide and death by physical disorders, but it has never been investigated whether these mortalities translate into relatives to patients with bipolar disorder. The aim was to present the life expectancy and the overall mortality and mortality due to suicide and physical disorders among patients with bipolar disorder and their unaffected full siblings, respectively, compared with control individuals from the general population. Methods: We used Danish nation-wide population-based longitudinal register linkage to identify 19.955 patients with bipolar disorder, their 13.923 siblings and 20 sex, age and calendar matched control individuals from the general population. Follow-up was from 1995 to 2017. Results: Bipolar disorder was associated with a decreased life expectancy of 7.7 (95% CI: 7.4-8.1) years and increased mortality overall (hazard ratio (HR): 2.11 (95% CI: 2.04-2.18)) and due to suicide (HR: 18.23 (95% CI: 15.81-21.02) and physical disorders (HR: 2.01 (95% CI: 1.94-2.08). In contrast, siblings to patients with bipolar disorder who were unaffected by bipolar disorder did not have decreased life expectancy (0.45 (95% CI: -6.622.46)) or increased mortality overall (HR: 1.00 (95% CI: 0.88-1.14) or due to suicide (HR: 1.50 (95% CI: 0.952.36) or physical disorders (HR: 0.99 (95% CI: 0.87-1.34). Conclusions: Increased mortality in bipolar disorder is mainly due to the impact of bipolar psychopathology and to a lesser degree to familial transmitted factors, highlighting the urgent need for preventive intervention studies in relation to suicide and physical disorders following onset of bipolar disorder.",
keywords = "Bipolar disorder, Siblings, Family history, Suicide, Physical diseases, Inflammation, METABOLIC SYNDROME, SUICIDE, METAANALYSIS, MECHANISMS, CYTOKINES, UNIPOLAR, DISEASE, RISK",
author = "Kessing, {Lars Vedel} and Ziersen, {Simon Christoffer} and Andersen, {Per Kragh} and Maj Vinberg",
year = "2021",
doi = "10.1016/j.jad.2021.07.065",
language = "English",
volume = "294",
pages = "472--476",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - A nation-wide population-based longitudinal study on life expectancy and cause specific mortality in patients with bipolar disorder and their siblings

AU - Kessing, Lars Vedel

AU - Ziersen, Simon Christoffer

AU - Andersen, Per Kragh

AU - Vinberg, Maj

PY - 2021

Y1 - 2021

N2 - Objective: Mortality is increased in bipolar disorder due to both suicide and death by physical disorders, but it has never been investigated whether these mortalities translate into relatives to patients with bipolar disorder. The aim was to present the life expectancy and the overall mortality and mortality due to suicide and physical disorders among patients with bipolar disorder and their unaffected full siblings, respectively, compared with control individuals from the general population. Methods: We used Danish nation-wide population-based longitudinal register linkage to identify 19.955 patients with bipolar disorder, their 13.923 siblings and 20 sex, age and calendar matched control individuals from the general population. Follow-up was from 1995 to 2017. Results: Bipolar disorder was associated with a decreased life expectancy of 7.7 (95% CI: 7.4-8.1) years and increased mortality overall (hazard ratio (HR): 2.11 (95% CI: 2.04-2.18)) and due to suicide (HR: 18.23 (95% CI: 15.81-21.02) and physical disorders (HR: 2.01 (95% CI: 1.94-2.08). In contrast, siblings to patients with bipolar disorder who were unaffected by bipolar disorder did not have decreased life expectancy (0.45 (95% CI: -6.622.46)) or increased mortality overall (HR: 1.00 (95% CI: 0.88-1.14) or due to suicide (HR: 1.50 (95% CI: 0.952.36) or physical disorders (HR: 0.99 (95% CI: 0.87-1.34). Conclusions: Increased mortality in bipolar disorder is mainly due to the impact of bipolar psychopathology and to a lesser degree to familial transmitted factors, highlighting the urgent need for preventive intervention studies in relation to suicide and physical disorders following onset of bipolar disorder.

AB - Objective: Mortality is increased in bipolar disorder due to both suicide and death by physical disorders, but it has never been investigated whether these mortalities translate into relatives to patients with bipolar disorder. The aim was to present the life expectancy and the overall mortality and mortality due to suicide and physical disorders among patients with bipolar disorder and their unaffected full siblings, respectively, compared with control individuals from the general population. Methods: We used Danish nation-wide population-based longitudinal register linkage to identify 19.955 patients with bipolar disorder, their 13.923 siblings and 20 sex, age and calendar matched control individuals from the general population. Follow-up was from 1995 to 2017. Results: Bipolar disorder was associated with a decreased life expectancy of 7.7 (95% CI: 7.4-8.1) years and increased mortality overall (hazard ratio (HR): 2.11 (95% CI: 2.04-2.18)) and due to suicide (HR: 18.23 (95% CI: 15.81-21.02) and physical disorders (HR: 2.01 (95% CI: 1.94-2.08). In contrast, siblings to patients with bipolar disorder who were unaffected by bipolar disorder did not have decreased life expectancy (0.45 (95% CI: -6.622.46)) or increased mortality overall (HR: 1.00 (95% CI: 0.88-1.14) or due to suicide (HR: 1.50 (95% CI: 0.952.36) or physical disorders (HR: 0.99 (95% CI: 0.87-1.34). Conclusions: Increased mortality in bipolar disorder is mainly due to the impact of bipolar psychopathology and to a lesser degree to familial transmitted factors, highlighting the urgent need for preventive intervention studies in relation to suicide and physical disorders following onset of bipolar disorder.

KW - Bipolar disorder

KW - Siblings

KW - Family history

KW - Suicide

KW - Physical diseases

KW - Inflammation

KW - METABOLIC SYNDROME

KW - SUICIDE

KW - METAANALYSIS

KW - MECHANISMS

KW - CYTOKINES

KW - UNIPOLAR

KW - DISEASE

KW - RISK

U2 - 10.1016/j.jad.2021.07.065

DO - 10.1016/j.jad.2021.07.065

M3 - Journal article

C2 - 34325167

VL - 294

SP - 472

EP - 476

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

ER -

ID: 279381701