A phenylpropanoid, a slovenolide, two sulphur-containing germacranes and Ca+2-ATPase inhibitors from Thapsia villosa

Research output: Contribution to journalJournal articleResearchpeer-review

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A phenylpropanoid, a slovenolide, two sulphur-containing germacranes and Ca+2-ATPase inhibitors from Thapsia villosa. / Rubal, Juan J; Moreno-Dorado, F Javier; Guerra, Francisco M; Jorge, Zacarías D; Galán, María del Carmen; Salido, Ginés M; Christensen, Søren Brøgger; Søhoel, Helmer; Massanet, Guillermo M.

In: Planta Medica, Vol. 76, No. 3, 2010, p. 284-290.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Rubal, JJ, Moreno-Dorado, FJ, Guerra, FM, Jorge, ZD, Galán, MDC, Salido, GM, Christensen, SB, Søhoel, H & Massanet, GM 2010, 'A phenylpropanoid, a slovenolide, two sulphur-containing germacranes and Ca+2-ATPase inhibitors from Thapsia villosa', Planta Medica, vol. 76, no. 3, pp. 284-290. https://doi.org/10.1055/s-0029-1186056

APA

Rubal, J. J., Moreno-Dorado, F. J., Guerra, F. M., Jorge, Z. D., Galán, M. D. C., Salido, G. M., ... Massanet, G. M. (2010). A phenylpropanoid, a slovenolide, two sulphur-containing germacranes and Ca+2-ATPase inhibitors from Thapsia villosa. Planta Medica, 76(3), 284-290. https://doi.org/10.1055/s-0029-1186056

Vancouver

Rubal JJ, Moreno-Dorado FJ, Guerra FM, Jorge ZD, Galán MDC, Salido GM et al. A phenylpropanoid, a slovenolide, two sulphur-containing germacranes and Ca+2-ATPase inhibitors from Thapsia villosa. Planta Medica. 2010;76(3):284-290. https://doi.org/10.1055/s-0029-1186056

Author

Rubal, Juan J ; Moreno-Dorado, F Javier ; Guerra, Francisco M ; Jorge, Zacarías D ; Galán, María del Carmen ; Salido, Ginés M ; Christensen, Søren Brøgger ; Søhoel, Helmer ; Massanet, Guillermo M. / A phenylpropanoid, a slovenolide, two sulphur-containing germacranes and Ca+2-ATPase inhibitors from Thapsia villosa. In: Planta Medica. 2010 ; Vol. 76, No. 3. pp. 284-290.

Bibtex

@article{58c32cc096d511de8bc9000ea68e967b,
title = "A phenylpropanoid, a slovenolide, two sulphur-containing germacranes and Ca+2-ATPase inhibitors from Thapsia villosa",
abstract = "A phenylpropanoid 1, a slovenolide 2, and two germacranes bearing a methylthiopropenoate moiety, 3 and 4, along with twenty known metabolites have been isolated from the roots of THAPSIA VILLOSA var. VILLOSA L. The structures of two known phenylpropanoids 5 and 6 have been corrected. Compounds 7 and 8 showed activity as potential inhibitors of the sarco- and endoplasmic Ca (2+)-dependent ATPases (SERCA) pump. Compounds 9, 10 and 11 increased significantly the cytoplasmic free calcium concentration ([Ca (2+)] (c)) in human platelets in a concentration-dependent manner.",
keywords = "The Faculty of Pharmaceutical Sciences",
author = "Rubal, {Juan J} and Moreno-Dorado, {F Javier} and Guerra, {Francisco M} and Jorge, {Zacar{\'i}as D} and Gal{\'a}n, {Mar{\'i}a del Carmen} and Salido, {Gin{\'e}s M} and Christensen, {S{\o}ren Br{\o}gger} and Helmer S{\o}hoel and Massanet, {Guillermo M}",
note = "Keywords: Thapsia villosa; Apiaceae; Germacranes; Phenylpropanoids; Slovenolides; Thapsigargins; Transtaganolides; Ca+2-ATPase inhibitors",
year = "2010",
doi = "10.1055/s-0029-1186056",
language = "English",
volume = "76",
pages = "284--290",
journal = "Planta Medica",
issn = "0032-0943",
publisher = "GeorgThieme Verlag",
number = "3",

}

RIS

TY - JOUR

T1 - A phenylpropanoid, a slovenolide, two sulphur-containing germacranes and Ca+2-ATPase inhibitors from Thapsia villosa

AU - Rubal, Juan J

AU - Moreno-Dorado, F Javier

AU - Guerra, Francisco M

AU - Jorge, Zacarías D

AU - Galán, María del Carmen

AU - Salido, Ginés M

AU - Christensen, Søren Brøgger

AU - Søhoel, Helmer

AU - Massanet, Guillermo M

N1 - Keywords: Thapsia villosa; Apiaceae; Germacranes; Phenylpropanoids; Slovenolides; Thapsigargins; Transtaganolides; Ca+2-ATPase inhibitors

PY - 2010

Y1 - 2010

N2 - A phenylpropanoid 1, a slovenolide 2, and two germacranes bearing a methylthiopropenoate moiety, 3 and 4, along with twenty known metabolites have been isolated from the roots of THAPSIA VILLOSA var. VILLOSA L. The structures of two known phenylpropanoids 5 and 6 have been corrected. Compounds 7 and 8 showed activity as potential inhibitors of the sarco- and endoplasmic Ca (2+)-dependent ATPases (SERCA) pump. Compounds 9, 10 and 11 increased significantly the cytoplasmic free calcium concentration ([Ca (2+)] (c)) in human platelets in a concentration-dependent manner.

AB - A phenylpropanoid 1, a slovenolide 2, and two germacranes bearing a methylthiopropenoate moiety, 3 and 4, along with twenty known metabolites have been isolated from the roots of THAPSIA VILLOSA var. VILLOSA L. The structures of two known phenylpropanoids 5 and 6 have been corrected. Compounds 7 and 8 showed activity as potential inhibitors of the sarco- and endoplasmic Ca (2+)-dependent ATPases (SERCA) pump. Compounds 9, 10 and 11 increased significantly the cytoplasmic free calcium concentration ([Ca (2+)] (c)) in human platelets in a concentration-dependent manner.

KW - The Faculty of Pharmaceutical Sciences

U2 - 10.1055/s-0029-1186056

DO - 10.1055/s-0029-1186056

M3 - Journal article

VL - 76

SP - 284

EP - 290

JO - Planta Medica

JF - Planta Medica

SN - 0032-0943

IS - 3

ER -

ID: 14119578