A single portion of blueberry (Vaccinium corymbosum L) improves protection against DNA damage but not vascular function in healthy male volunteers

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

A single portion of blueberry (Vaccinium corymbosum L) improves protection against DNA damage but not vascular function in healthy male volunteers. / Del Bo, Cristian; Riso, Patrizia; Campolo, Jonica; Møller, Peter; Loft, Steffen; Klimis-Zacas, Dorothy; Brambilla, Ada; Rizzolo, Anna; Porrini, Marisa.

In: Nutrition Research, Vol. 33, No. 3, 03.2013, p. 220-7.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Del Bo, C, Riso, P, Campolo, J, Møller, P, Loft, S, Klimis-Zacas, D, Brambilla, A, Rizzolo, A & Porrini, M 2013, 'A single portion of blueberry (Vaccinium corymbosum L) improves protection against DNA damage but not vascular function in healthy male volunteers', Nutrition Research, vol. 33, no. 3, pp. 220-7. https://doi.org/10.1016/j.nutres.2012.12.009

APA

Del Bo, C., Riso, P., Campolo, J., Møller, P., Loft, S., Klimis-Zacas, D., ... Porrini, M. (2013). A single portion of blueberry (Vaccinium corymbosum L) improves protection against DNA damage but not vascular function in healthy male volunteers. Nutrition Research, 33(3), 220-7. https://doi.org/10.1016/j.nutres.2012.12.009

Vancouver

Del Bo C, Riso P, Campolo J, Møller P, Loft S, Klimis-Zacas D et al. A single portion of blueberry (Vaccinium corymbosum L) improves protection against DNA damage but not vascular function in healthy male volunteers. Nutrition Research. 2013 Mar;33(3):220-7. https://doi.org/10.1016/j.nutres.2012.12.009

Author

Del Bo, Cristian ; Riso, Patrizia ; Campolo, Jonica ; Møller, Peter ; Loft, Steffen ; Klimis-Zacas, Dorothy ; Brambilla, Ada ; Rizzolo, Anna ; Porrini, Marisa. / A single portion of blueberry (Vaccinium corymbosum L) improves protection against DNA damage but not vascular function in healthy male volunteers. In: Nutrition Research. 2013 ; Vol. 33, No. 3. pp. 220-7.

Bibtex

@article{fb9b050e600940fd90d8db3faf26011f,
title = "A single portion of blueberry (Vaccinium corymbosum L) improves protection against DNA damage but not vascular function in healthy male volunteers",
abstract = "It has been suggested that anthocyanin-rich foods may exert antioxidant effects and improve vascular function as demonstrated mainly in vitro and in the animal model. Blueberries are rich sources of anthocyanins and we hypothesized that their intake could improve cell protection against oxidative stress and affect endothelial function in humans. The aim of the study was to investigate the effect of one portion (300 g) of blueberries on selected markers of oxidative stress and antioxidant protection (endogenous and oxidatively induced DNA damage) and of vascular function (changes in peripheral arterial tone and plasma nitric oxide levels) in male subjects. In a randomized cross-over design, separated by a wash out period ten young volunteers received one portion of blueberries ground by blender or one portion of a control jelly. Before and after consumption (at 1, 2, and 24 hours), blood samples were collected and used to evaluate anthocyanin absorption (through mass spectrometry), endogenous and H(2)O(2)-induced DNA damage in blood mononuclear cells (through the comet assay), and plasma nitric oxide concentrations (through a fluorometric assay). Peripheral arterial function was assessed by means of Endo-PAT 2000. Blueberries significantly reduced (P <.01) H(2)O(2)-induced DNA damage (-18{\%}) 1 hour after blueberry consumption compared to control. No significant differences were observed for endogenous DNA damage, peripheral arterial function and nitric oxide levels after blueberry intake. In conclusion, one portion of blueberries seems sufficient to improve cell antioxidant defense against DNA damage, but further studies are necessary to understand their role on vascular function.",
author = "{Del Bo}, Cristian and Patrizia Riso and Jonica Campolo and Peter M{\o}ller and Steffen Loft and Dorothy Klimis-Zacas and Ada Brambilla and Anna Rizzolo and Marisa Porrini",
note = "Copyright {\circledC} 2013 Elsevier Inc. All rights reserved.",
year = "2013",
month = "3",
doi = "10.1016/j.nutres.2012.12.009",
language = "English",
volume = "33",
pages = "220--7",
journal = "Nutrition Research",
issn = "0271-5317",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - A single portion of blueberry (Vaccinium corymbosum L) improves protection against DNA damage but not vascular function in healthy male volunteers

AU - Del Bo, Cristian

AU - Riso, Patrizia

AU - Campolo, Jonica

AU - Møller, Peter

AU - Loft, Steffen

AU - Klimis-Zacas, Dorothy

AU - Brambilla, Ada

AU - Rizzolo, Anna

AU - Porrini, Marisa

N1 - Copyright © 2013 Elsevier Inc. All rights reserved.

PY - 2013/3

Y1 - 2013/3

N2 - It has been suggested that anthocyanin-rich foods may exert antioxidant effects and improve vascular function as demonstrated mainly in vitro and in the animal model. Blueberries are rich sources of anthocyanins and we hypothesized that their intake could improve cell protection against oxidative stress and affect endothelial function in humans. The aim of the study was to investigate the effect of one portion (300 g) of blueberries on selected markers of oxidative stress and antioxidant protection (endogenous and oxidatively induced DNA damage) and of vascular function (changes in peripheral arterial tone and plasma nitric oxide levels) in male subjects. In a randomized cross-over design, separated by a wash out period ten young volunteers received one portion of blueberries ground by blender or one portion of a control jelly. Before and after consumption (at 1, 2, and 24 hours), blood samples were collected and used to evaluate anthocyanin absorption (through mass spectrometry), endogenous and H(2)O(2)-induced DNA damage in blood mononuclear cells (through the comet assay), and plasma nitric oxide concentrations (through a fluorometric assay). Peripheral arterial function was assessed by means of Endo-PAT 2000. Blueberries significantly reduced (P <.01) H(2)O(2)-induced DNA damage (-18%) 1 hour after blueberry consumption compared to control. No significant differences were observed for endogenous DNA damage, peripheral arterial function and nitric oxide levels after blueberry intake. In conclusion, one portion of blueberries seems sufficient to improve cell antioxidant defense against DNA damage, but further studies are necessary to understand their role on vascular function.

AB - It has been suggested that anthocyanin-rich foods may exert antioxidant effects and improve vascular function as demonstrated mainly in vitro and in the animal model. Blueberries are rich sources of anthocyanins and we hypothesized that their intake could improve cell protection against oxidative stress and affect endothelial function in humans. The aim of the study was to investigate the effect of one portion (300 g) of blueberries on selected markers of oxidative stress and antioxidant protection (endogenous and oxidatively induced DNA damage) and of vascular function (changes in peripheral arterial tone and plasma nitric oxide levels) in male subjects. In a randomized cross-over design, separated by a wash out period ten young volunteers received one portion of blueberries ground by blender or one portion of a control jelly. Before and after consumption (at 1, 2, and 24 hours), blood samples were collected and used to evaluate anthocyanin absorption (through mass spectrometry), endogenous and H(2)O(2)-induced DNA damage in blood mononuclear cells (through the comet assay), and plasma nitric oxide concentrations (through a fluorometric assay). Peripheral arterial function was assessed by means of Endo-PAT 2000. Blueberries significantly reduced (P <.01) H(2)O(2)-induced DNA damage (-18%) 1 hour after blueberry consumption compared to control. No significant differences were observed for endogenous DNA damage, peripheral arterial function and nitric oxide levels after blueberry intake. In conclusion, one portion of blueberries seems sufficient to improve cell antioxidant defense against DNA damage, but further studies are necessary to understand their role on vascular function.

U2 - 10.1016/j.nutres.2012.12.009

DO - 10.1016/j.nutres.2012.12.009

M3 - Journal article

C2 - 23507228

VL - 33

SP - 220

EP - 227

JO - Nutrition Research

JF - Nutrition Research

SN - 0271-5317

IS - 3

ER -

ID: 45488159