Accumulation of childhood adversities and type 1 diabetes risk: a register-based cohort study of all children born in Denmark between 1980 and 2015
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Accumulation of childhood adversities and type 1 diabetes risk : a register-based cohort study of all children born in Denmark between 1980 and 2015. / Bengtsson, Jessica; Byberg, Stine; Carstensen, Bendix; De Stavola, Bianca L; Svensson, Jannet; Jørgensen, Marit E.; Rod, Naja H.
In: International Journal of Epidemiology, Vol. 49, No. 5, 2020, p. 1604-1613.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Accumulation of childhood adversities and type 1 diabetes risk
T2 - a register-based cohort study of all children born in Denmark between 1980 and 2015
AU - Bengtsson, Jessica
AU - Byberg, Stine
AU - Carstensen, Bendix
AU - De Stavola, Bianca L
AU - Svensson, Jannet
AU - Jørgensen, Marit E.
AU - Rod, Naja H
N1 - © The Author(s) 2020. Published by Oxford University Press on behalf of the International Epidemiological Association.
PY - 2020
Y1 - 2020
N2 - BACKGROUND: Previous studies have indicated an association between childhood adversities and type 1 diabetes but have been underpowered and limited by selection. We aim to quantify the effect of accumulation of childhood adversities on type 1 diabetes risk, and to assess whether the effect differs between males and females in a large and unselected population sample.METHODS: We used register-based data covering all children born in Denmark between 1980 and 2015, totalling >2 million children. We specified a multi-state model to quantify the effect of accumulation of childhood adversities on type 1 diabetes risk. The effects of specific childhood adversities on type 1 diabetes were estimated using proportional hazards models.RESULTS: Accumulation of childhood adversities had a quantitatively small effect on type 1 diabetes risk among females [adjusted hazard ratio (HR) per adversity increase: 1.07; 95% confidence interval (CI): 1.02-1.11], but not among males (adjusted HR per adversity increase: 0.99; 95% CI: 0.97-1.03). Females exposed to extreme numbers (7+) of adversities had two times higher risk of type 1 diabetes compared with unexposed females (adjusted HR: 2.06; 95% CI: 1.10-3.86).CONCLUSIONS: In an unselected total population sample, we generally find no or negligible effects of childhood adversities on type 1 diabetes risk, which may be reassuring to persons with type 1 diabetes who are concerned that personal trauma contributed to their disease. There is a very small group of females exposed to a high degree of adversity who may have a higher risk of type 1 diabetes and this group needs further attention.
AB - BACKGROUND: Previous studies have indicated an association between childhood adversities and type 1 diabetes but have been underpowered and limited by selection. We aim to quantify the effect of accumulation of childhood adversities on type 1 diabetes risk, and to assess whether the effect differs between males and females in a large and unselected population sample.METHODS: We used register-based data covering all children born in Denmark between 1980 and 2015, totalling >2 million children. We specified a multi-state model to quantify the effect of accumulation of childhood adversities on type 1 diabetes risk. The effects of specific childhood adversities on type 1 diabetes were estimated using proportional hazards models.RESULTS: Accumulation of childhood adversities had a quantitatively small effect on type 1 diabetes risk among females [adjusted hazard ratio (HR) per adversity increase: 1.07; 95% confidence interval (CI): 1.02-1.11], but not among males (adjusted HR per adversity increase: 0.99; 95% CI: 0.97-1.03). Females exposed to extreme numbers (7+) of adversities had two times higher risk of type 1 diabetes compared with unexposed females (adjusted HR: 2.06; 95% CI: 1.10-3.86).CONCLUSIONS: In an unselected total population sample, we generally find no or negligible effects of childhood adversities on type 1 diabetes risk, which may be reassuring to persons with type 1 diabetes who are concerned that personal trauma contributed to their disease. There is a very small group of females exposed to a high degree of adversity who may have a higher risk of type 1 diabetes and this group needs further attention.
U2 - 10.1093/ije/dyaa138
DO - 10.1093/ije/dyaa138
M3 - Journal article
C2 - 33005951
VL - 49
SP - 1604
EP - 1613
JO - International Journal of Epidemiology
JF - International Journal of Epidemiology
SN - 0300-5771
IS - 5
ER -
ID: 250436871