Acute-phase responses in healthy and diseased rhesus macaques (Macaca mulatta)

Research output: Contribution to journal › Journal article › peer-review

Standard

Acute-phase responses in healthy and diseased rhesus macaques (Macaca mulatta). / Krogh, Anne Kirstine Havnsøe; Lundsgaard, Jo F. H.; Bakker, Jaco; Langermans, Jan A. M.; Verreck, Frank A. W.; Kjelgaard-Hansen, Mads; Jacobsen, Stine; Bertelsen, Mads Frost.

In: Journal of Zoo and Wildlife Medicine, Vol. 45, No. 2, 2014, p. 306-314.

Research output: Contribution to journal › Journal article › peer-review

Harvard

Krogh, AKH, Lundsgaard, JFH, Bakker, J, Langermans, JAM, Verreck, FAW, Kjelgaard-Hansen, M, Jacobsen, S & Bertelsen, MF 2014, 'Acute-phase responses in healthy and diseased rhesus macaques (Macaca mulatta)', Journal of Zoo and Wildlife Medicine, vol. 45, no. 2, pp. 306-314. https://doi.org/10.1638/2013-0153R.1

APA

Krogh, A. K. H., Lundsgaard, J. F. H., Bakker, J., Langermans, J. A. M., Verreck, F. A. W., Kjelgaard-Hansen, M., Jacobsen, S., & Bertelsen, M. F. (2014). Acute-phase responses in healthy and diseased rhesus macaques (Macaca mulatta). Journal of Zoo and Wildlife Medicine, 45(2), 306-314. https://doi.org/10.1638/2013-0153R.1

Vancouver

Krogh AKH, Lundsgaard JFH, Bakker J, Langermans JAM, Verreck FAW, Kjelgaard-Hansen M et al. Acute-phase responses in healthy and diseased rhesus macaques (Macaca mulatta). Journal of Zoo and Wildlife Medicine. 2014;45(2):306-314. https://doi.org/10.1638/2013-0153R.1

Author

Krogh, Anne Kirstine Havnsøe ; Lundsgaard, Jo F. H. ; Bakker, Jaco ; Langermans, Jan A. M. ; Verreck, Frank A. W. ; Kjelgaard-Hansen, Mads ; Jacobsen, Stine ; Bertelsen, Mads Frost. / Acute-phase responses in healthy and diseased rhesus macaques (Macaca mulatta). In: Journal of Zoo and Wildlife Medicine. 2014 ; Vol. 45, No. 2. pp. 306-314.

Bibtex

@article{41af7c356b3f48008b692afc92e4c3f9,
title = "Acute-phase responses in healthy and diseased rhesus macaques (Macaca mulatta)",
abstract = "Five acute-phase reactants—serum amyloid A (SAA), C-reactive protein (CRP), haptoglobin, albumin, and iron—were measured using commercially available assays in 110 healthy rhesus macaques (Macaca mulatta), and reference intervals were established for future use in health monitoring of this species. Reference intervals established were as follows: SAA, 29.5–87.7 mg/L; CRP, 0–17.5 mg/L; haptoglobin, 354.3–2,414.7 mg/L; albumin, 36.1–53.0 g/L; and iron, 13.3–40.2 lmol/L. Furthermore, changes in the acute-phase reactants were studied in two additional groups of animals: eight rhesus macaques suffering from acute traumatic injuries and nine rhesus macaques experimentally infected with Mycobacterium tuberculosis reflecting a chronic active inflammation. In animals with inflammation, SAA and haptoglobin concentrations were moderately increased, while CRP increased more than 200-fold. In addition, marked decreases in albumin and iron concentrations were observed. These results show that SAA, CRP, and haptoglobin are positive acute-phase proteins, whereas albumin and iron are negative acute-phase reactants in rhesus macaques.",
keywords = "Faculty of Health and Medical Sciences, Primates, Inflammation, Acute phase proteins, Veterinary medicine",
author = "Krogh, {Anne Kirstine Havns{\o}e} and Lundsgaard, {Jo F. H.} and Jaco Bakker and Langermans, {Jan A. M.} and Verreck, {Frank A. W.} and Mads Kjelgaard-Hansen and Stine Jacobsen and Bertelsen, {Mads Frost}",
year = "2014",
doi = "10.1638/2013-0153R.1",
language = "English",
volume = "45",
pages = "306--314",
journal = "Journal of Zoo and Wildlife Medicine",
issn = "1042-7260",
publisher = "American Association of Zoo Veterinarians",
number = "2",

}

RIS

TY - JOUR

T1 - Acute-phase responses in healthy and diseased rhesus macaques (Macaca mulatta)

AU - Krogh, Anne Kirstine Havnsøe

AU - Lundsgaard, Jo F. H.

AU - Bakker, Jaco

AU - Langermans, Jan A. M.

AU - Verreck, Frank A. W.

AU - Kjelgaard-Hansen, Mads

AU - Jacobsen, Stine

AU - Bertelsen, Mads Frost

PY - 2014

Y1 - 2014

N2 - Five acute-phase reactants—serum amyloid A (SAA), C-reactive protein (CRP), haptoglobin, albumin, and iron—were measured using commercially available assays in 110 healthy rhesus macaques (Macaca mulatta), and reference intervals were established for future use in health monitoring of this species. Reference intervals established were as follows: SAA, 29.5–87.7 mg/L; CRP, 0–17.5 mg/L; haptoglobin, 354.3–2,414.7 mg/L; albumin, 36.1–53.0 g/L; and iron, 13.3–40.2 lmol/L. Furthermore, changes in the acute-phase reactants were studied in two additional groups of animals: eight rhesus macaques suffering from acute traumatic injuries and nine rhesus macaques experimentally infected with Mycobacterium tuberculosis reflecting a chronic active inflammation. In animals with inflammation, SAA and haptoglobin concentrations were moderately increased, while CRP increased more than 200-fold. In addition, marked decreases in albumin and iron concentrations were observed. These results show that SAA, CRP, and haptoglobin are positive acute-phase proteins, whereas albumin and iron are negative acute-phase reactants in rhesus macaques.

AB - Five acute-phase reactants—serum amyloid A (SAA), C-reactive protein (CRP), haptoglobin, albumin, and iron—were measured using commercially available assays in 110 healthy rhesus macaques (Macaca mulatta), and reference intervals were established for future use in health monitoring of this species. Reference intervals established were as follows: SAA, 29.5–87.7 mg/L; CRP, 0–17.5 mg/L; haptoglobin, 354.3–2,414.7 mg/L; albumin, 36.1–53.0 g/L; and iron, 13.3–40.2 lmol/L. Furthermore, changes in the acute-phase reactants were studied in two additional groups of animals: eight rhesus macaques suffering from acute traumatic injuries and nine rhesus macaques experimentally infected with Mycobacterium tuberculosis reflecting a chronic active inflammation. In animals with inflammation, SAA and haptoglobin concentrations were moderately increased, while CRP increased more than 200-fold. In addition, marked decreases in albumin and iron concentrations were observed. These results show that SAA, CRP, and haptoglobin are positive acute-phase proteins, whereas albumin and iron are negative acute-phase reactants in rhesus macaques.

KW - Faculty of Health and Medical Sciences

KW - Primates

KW - Inflammation

KW - Acute phase proteins

KW - Veterinary medicine

U2 - 10.1638/2013-0153R.1

DO - 10.1638/2013-0153R.1

M3 - Journal article

C2 - 25000691

VL - 45

SP - 306

EP - 314

JO - Journal of Zoo and Wildlife Medicine

JF - Journal of Zoo and Wildlife Medicine

SN - 1042-7260

IS - 2

ER -

ID: 119242373