Advancing human gut microbiota research by considering gut transit time
Research output: Contribution to journal › Journal article › Research › peer-review
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Advancing human gut microbiota research by considering gut transit time. / Procházková, Nicola; Falony, Gwen; Dragsted, Lars Ove; Licht, Tine Rask; Raes, Jeroen; Roager, Henrik Munch.
In: Gut, Vol. 72, No. 1, 2023, p. 180-191.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Advancing human gut microbiota research by considering gut transit time
AU - Procházková, Nicola
AU - Falony, Gwen
AU - Dragsted, Lars Ove
AU - Licht, Tine Rask
AU - Raes, Jeroen
AU - Roager, Henrik Munch
N1 - CURIS 2023 NEXS 003
PY - 2023
Y1 - 2023
N2 - Accumulating evidence indicates that gut transit time is a key factor in shaping the gut microbiota composition and activity, which are linked to human health. Both population-wide and small-scale studies have identified transit time as a top covariate contributing to the large interindividual variation in the faecal microbiota composition. Despite this, transit time is still rarely being considered in the field of the human gut microbiome. Here, we review the latest research describing how and why whole gut and segmental transit times varysubstantially between and within individuals, and how variations in gut transit time impact the gut microbiota composition, diversity and metabolism.Furthermore, we discuss the mechanisms by which the gut microbiota may causally affect gut motility. We argue that by taking into account the interindividual and intraindividual differences in gut transit time, we can advance our understanding of diet–microbiota interactions and disease-related microbiome signatures, since these may often be confounded by transient orpersistent alterations in transit time. Altogether, a better understanding of the complex, bidirectional interactions between the gut microbiota and transit time is required to better understand gut microbiome variations in health and disease.
AB - Accumulating evidence indicates that gut transit time is a key factor in shaping the gut microbiota composition and activity, which are linked to human health. Both population-wide and small-scale studies have identified transit time as a top covariate contributing to the large interindividual variation in the faecal microbiota composition. Despite this, transit time is still rarely being considered in the field of the human gut microbiome. Here, we review the latest research describing how and why whole gut and segmental transit times varysubstantially between and within individuals, and how variations in gut transit time impact the gut microbiota composition, diversity and metabolism.Furthermore, we discuss the mechanisms by which the gut microbiota may causally affect gut motility. We argue that by taking into account the interindividual and intraindividual differences in gut transit time, we can advance our understanding of diet–microbiota interactions and disease-related microbiome signatures, since these may often be confounded by transient orpersistent alterations in transit time. Altogether, a better understanding of the complex, bidirectional interactions between the gut microbiota and transit time is required to better understand gut microbiome variations in health and disease.
KW - Faculty of Science
KW - Gut transit time
KW - Gut microbiota composition
KW - Gut microbiota activity
KW - Human health
U2 - 10.1136/gutjnl-2022-328166
DO - 10.1136/gutjnl-2022-328166
M3 - Journal article
C2 - 36171079
VL - 72
SP - 180
EP - 191
JO - Gut
JF - Gut
SN - 0017-5749
IS - 1
ER -
ID: 321159952