TY - JOUR

T1 - Aggression and personality

T2 - Association with amino acids and monoamine metabolites

AU - Møller, S. E.

AU - Mortensen, E. L.

AU - Breum, L.

AU - Alling, C.

AU - Larsen, O. G.

AU - Bøge-Rasmussen, T.

AU - Jensen, C.

AU - Bennicke, K.

N1 - Funding Information: The Kinsey Reaction List II was developed as part of the Prenatal Development Project supported by United States Public Health Service (USPHS) grants HD 17655 and HD20263 from the National Institute of Child Health and Human Development to June Reinisch and USPHS grant DA05056 from the National Institute on Drug Abuse to June Reinisch and Stephanie Sanders. The study was, furthermore, supported by grants from the Psychiatric Research Foundation and the Lundbeck Foundation.

PY - 1996/3

Y1 - 1996/3

N2 - Associations in 52 normal individuals were examined between plasma and cerebrospinal fluid (CSF) concentrations of tryptophan (Trp) and tyrosine, and concentrations of monoamine metabolites in the CSF, and scores on an aggression questionnaire, the Kinsey Institute Reaction List II, and the Eysenck Personality Questionnaire. There was a significantly positive correlation between CSF 5-hydroxyindoleacetic acid (5-HIAA) levels and extroverted aggression scores, and a significantly negative correlation between CSF 5-HIAA levels and introverted aggression scores. Males showed higher plasma Trp concentrations than females, and significantly positive correlations between plasma Trp concentrations and scores on extroverted aggression and the Eysenck E scale. Males, furthermore, showed a significantly negative correlation between CSF Trp levels and scores on the Eysenck P scale, and a significantly positive correlation between concentrations of 3-methoxy-4-hydroxy-phenylglycol in CSF and scores on moral aggression. These results suggest that central serotonin influences aggression in normal individuals through effects on personality.

AB - Associations in 52 normal individuals were examined between plasma and cerebrospinal fluid (CSF) concentrations of tryptophan (Trp) and tyrosine, and concentrations of monoamine metabolites in the CSF, and scores on an aggression questionnaire, the Kinsey Institute Reaction List II, and the Eysenck Personality Questionnaire. There was a significantly positive correlation between CSF 5-hydroxyindoleacetic acid (5-HIAA) levels and extroverted aggression scores, and a significantly negative correlation between CSF 5-HIAA levels and introverted aggression scores. Males showed higher plasma Trp concentrations than females, and significantly positive correlations between plasma Trp concentrations and scores on extroverted aggression and the Eysenck E scale. Males, furthermore, showed a significantly negative correlation between CSF Trp levels and scores on the Eysenck P scale, and a significantly positive correlation between concentrations of 3-methoxy-4-hydroxy-phenylglycol in CSF and scores on moral aggression. These results suggest that central serotonin influences aggression in normal individuals through effects on personality.

UR - http://www.scopus.com/inward/record.url?scp=0029978205&partnerID=8YFLogxK

U2 - 10.1017/s0033291700034711

DO - 10.1017/s0033291700034711

M3 - Journal article

C2 - 8685288

AN - SCOPUS:0029978205

VL - 26

SP - 323

EP - 331

JO - Psychological Medicine

JF - Psychological Medicine

SN - 0033-2917

IS - 2

ER -