AMH as Predictor of Premature Ovarian Insufficiency: A Longitudinal Study of 120 Turner Syndrome Patients

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AMH as Predictor of Premature Ovarian Insufficiency : A Longitudinal Study of 120 Turner Syndrome Patients. / Lunding, Stine Aa; Aksglæde, Lise; Anderson, Richard A; Main, Katharina M; Juul, Anders; Hagen, Casper P; Pedersen, Anette T.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 100, No. 7, 07.2015, p. E1030-8.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Lunding, SA, Aksglæde, L, Anderson, RA, Main, KM, Juul, A, Hagen, CP & Pedersen, AT 2015, 'AMH as Predictor of Premature Ovarian Insufficiency: A Longitudinal Study of 120 Turner Syndrome Patients', Journal of Clinical Endocrinology and Metabolism, vol. 100, no. 7, pp. E1030-8. https://doi.org/10.1210/jc.2015-1621

APA

Lunding, S. A., Aksglæde, L., Anderson, R. A., Main, K. M., Juul, A., Hagen, C. P., & Pedersen, A. T. (2015). AMH as Predictor of Premature Ovarian Insufficiency: A Longitudinal Study of 120 Turner Syndrome Patients. Journal of Clinical Endocrinology and Metabolism, 100(7), E1030-8. https://doi.org/10.1210/jc.2015-1621

Vancouver

Lunding SA, Aksglæde L, Anderson RA, Main KM, Juul A, Hagen CP et al. AMH as Predictor of Premature Ovarian Insufficiency: A Longitudinal Study of 120 Turner Syndrome Patients. Journal of Clinical Endocrinology and Metabolism. 2015 Jul;100(7):E1030-8. https://doi.org/10.1210/jc.2015-1621

Author

Lunding, Stine Aa ; Aksglæde, Lise ; Anderson, Richard A ; Main, Katharina M ; Juul, Anders ; Hagen, Casper P ; Pedersen, Anette T. / AMH as Predictor of Premature Ovarian Insufficiency : A Longitudinal Study of 120 Turner Syndrome Patients. In: Journal of Clinical Endocrinology and Metabolism. 2015 ; Vol. 100, No. 7. pp. E1030-8.

Bibtex

@article{ea3d4442eaf942d8b8ae392c0001ccec,
title = "AMH as Predictor of Premature Ovarian Insufficiency: A Longitudinal Study of 120 Turner Syndrome Patients",
abstract = "CONTEXT: The majority of Turner syndrome (TS) patients suffer from accelerated loss of primordial follicles. Low circulating levels of anti-M{\"u}llerian hormone (AMH) may predict the lack of spontaneous puberty in prepubertal girls and imminent premature ovarian insufficiency (POI) in TS women with preserved ovarian function.OBJECTIVES: To evaluate the association between circulating AMH and ovarian status in TS patients.DESIGN: Longitudinal observational cohort study.SETTING: Tertiary referral center for pediatric and gynecologic endocrinology.PARTICIPANTS: A total of 120 TS patients, aged 0 to 48 years.MAIN OUTCOME MEASURES: Longitudinal measurements of AMH, FSH, LH, estradiol, and inhibin B according to age, karyotype (45,X; 45,X/46,XX mosaicism; miscellaneous karyotypes), and ovarian status (group 0, prepubertal; group 1, never ovarian function; group 2, ongoing ovarian function; and group 3, loss of ovarian function).RESULTS: Ovarian status was highly associated with the TS karyotype: spontaneous puberty—45,X (three of 44 patients), 45,X/46,XX (15 of 17), miscellaneous (17 of 42); and POI—45,X (three of three), 45,X/46,XX (one of 15), and miscellaneous (eight of 17). AMH was associated with ovarian status (eg, group 1, <2 pmol/L; vs group 2, 19 pmol/L; P < .001). AMH < 4 pmol/L (corresponding to <-2 SD) predicted absent puberty in prepubertal girls and POI in adolescent and adult patients.CONCLUSION: The majority of women with mosaic karyotype 45,X/46,XX had ongoing ovarian function in early adulthood. AMH < -2 SD predicted failure to enter puberty in young TS girls and imminent POI in adolescent and adult TS patients.",
keywords = "Adolescent, Adult, Anti-Mullerian Hormone, Biomarkers, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Longitudinal Studies, Middle Aged, Primary Ovarian Insufficiency, Prognosis, Turner Syndrome, Young Adult",
author = "Lunding, {Stine Aa} and Lise Aksgl{\ae}de and Anderson, {Richard A} and Main, {Katharina M} and Anders Juul and Hagen, {Casper P} and Pedersen, {Anette T}",
year = "2015",
month = "7",
doi = "10.1210/jc.2015-1621",
language = "English",
volume = "100",
pages = "E1030--8",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "Oxford University Press",
number = "7",

}

RIS

TY - JOUR

T1 - AMH as Predictor of Premature Ovarian Insufficiency

T2 - A Longitudinal Study of 120 Turner Syndrome Patients

AU - Lunding, Stine Aa

AU - Aksglæde, Lise

AU - Anderson, Richard A

AU - Main, Katharina M

AU - Juul, Anders

AU - Hagen, Casper P

AU - Pedersen, Anette T

PY - 2015/7

Y1 - 2015/7

N2 - CONTEXT: The majority of Turner syndrome (TS) patients suffer from accelerated loss of primordial follicles. Low circulating levels of anti-Müllerian hormone (AMH) may predict the lack of spontaneous puberty in prepubertal girls and imminent premature ovarian insufficiency (POI) in TS women with preserved ovarian function.OBJECTIVES: To evaluate the association between circulating AMH and ovarian status in TS patients.DESIGN: Longitudinal observational cohort study.SETTING: Tertiary referral center for pediatric and gynecologic endocrinology.PARTICIPANTS: A total of 120 TS patients, aged 0 to 48 years.MAIN OUTCOME MEASURES: Longitudinal measurements of AMH, FSH, LH, estradiol, and inhibin B according to age, karyotype (45,X; 45,X/46,XX mosaicism; miscellaneous karyotypes), and ovarian status (group 0, prepubertal; group 1, never ovarian function; group 2, ongoing ovarian function; and group 3, loss of ovarian function).RESULTS: Ovarian status was highly associated with the TS karyotype: spontaneous puberty—45,X (three of 44 patients), 45,X/46,XX (15 of 17), miscellaneous (17 of 42); and POI—45,X (three of three), 45,X/46,XX (one of 15), and miscellaneous (eight of 17). AMH was associated with ovarian status (eg, group 1, <2 pmol/L; vs group 2, 19 pmol/L; P < .001). AMH < 4 pmol/L (corresponding to <-2 SD) predicted absent puberty in prepubertal girls and POI in adolescent and adult patients.CONCLUSION: The majority of women with mosaic karyotype 45,X/46,XX had ongoing ovarian function in early adulthood. AMH < -2 SD predicted failure to enter puberty in young TS girls and imminent POI in adolescent and adult TS patients.

AB - CONTEXT: The majority of Turner syndrome (TS) patients suffer from accelerated loss of primordial follicles. Low circulating levels of anti-Müllerian hormone (AMH) may predict the lack of spontaneous puberty in prepubertal girls and imminent premature ovarian insufficiency (POI) in TS women with preserved ovarian function.OBJECTIVES: To evaluate the association between circulating AMH and ovarian status in TS patients.DESIGN: Longitudinal observational cohort study.SETTING: Tertiary referral center for pediatric and gynecologic endocrinology.PARTICIPANTS: A total of 120 TS patients, aged 0 to 48 years.MAIN OUTCOME MEASURES: Longitudinal measurements of AMH, FSH, LH, estradiol, and inhibin B according to age, karyotype (45,X; 45,X/46,XX mosaicism; miscellaneous karyotypes), and ovarian status (group 0, prepubertal; group 1, never ovarian function; group 2, ongoing ovarian function; and group 3, loss of ovarian function).RESULTS: Ovarian status was highly associated with the TS karyotype: spontaneous puberty—45,X (three of 44 patients), 45,X/46,XX (15 of 17), miscellaneous (17 of 42); and POI—45,X (three of three), 45,X/46,XX (one of 15), and miscellaneous (eight of 17). AMH was associated with ovarian status (eg, group 1, <2 pmol/L; vs group 2, 19 pmol/L; P < .001). AMH < 4 pmol/L (corresponding to <-2 SD) predicted absent puberty in prepubertal girls and POI in adolescent and adult patients.CONCLUSION: The majority of women with mosaic karyotype 45,X/46,XX had ongoing ovarian function in early adulthood. AMH < -2 SD predicted failure to enter puberty in young TS girls and imminent POI in adolescent and adult TS patients.

KW - Adolescent

KW - Adult

KW - Anti-Mullerian Hormone

KW - Biomarkers

KW - Child

KW - Child, Preschool

KW - Female

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Longitudinal Studies

KW - Middle Aged

KW - Primary Ovarian Insufficiency

KW - Prognosis

KW - Turner Syndrome

KW - Young Adult

U2 - 10.1210/jc.2015-1621

DO - 10.1210/jc.2015-1621

M3 - Journal article

C2 - 25978111

VL - 100

SP - E1030-8

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 7

ER -

ID: 160446658