Amniotic fluid MMP-9 and neurotrophins in autism spectrum disorders: an exploratory study

Research output: Contribution to journal › Journal article › Research › peer-review

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Amniotic fluid MMP-9 and neurotrophins in autism spectrum disorders : an exploratory study. / Abdallah, Morsi; Pearce, Brad D; Larsen, Nanna ; Greaves-Lord, Kirstin; Nørgaard-Pedersen, Bent; Hougaard, David M; Mortensen, Erik L; Grove, Jakob.

In: Autism Research, Vol. 5, No. 6, 12.2012, p. 428-33.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Abdallah, M, Pearce, BD, Larsen, N, Greaves-Lord, K, Nørgaard-Pedersen, B, Hougaard, DM, Mortensen, EL & Grove, J 2012, 'Amniotic fluid MMP-9 and neurotrophins in autism spectrum disorders: an exploratory study', Autism Research, vol. 5, no. 6, pp. 428-33. https://doi.org/10.1002/aur.1254

APA

Abdallah, M., Pearce, B. D., Larsen, N., Greaves-Lord, K., Nørgaard-Pedersen, B., Hougaard, D. M., Mortensen, E. L., & Grove, J. (2012). Amniotic fluid MMP-9 and neurotrophins in autism spectrum disorders: an exploratory study. Autism Research, 5(6), 428-33. https://doi.org/10.1002/aur.1254

Vancouver

Abdallah M, Pearce BD, Larsen N, Greaves-Lord K, Nørgaard-Pedersen B, Hougaard DM et al. Amniotic fluid MMP-9 and neurotrophins in autism spectrum disorders: an exploratory study. Autism Research. 2012 Dec;5(6):428-33. https://doi.org/10.1002/aur.1254

Author

Abdallah, Morsi ; Pearce, Brad D ; Larsen, Nanna ; Greaves-Lord, Kirstin ; Nørgaard-Pedersen, Bent ; Hougaard, David M ; Mortensen, Erik L ; Grove, Jakob. / Amniotic fluid MMP-9 and neurotrophins in autism spectrum disorders : an exploratory study. In: Autism Research. 2012 ; Vol. 5, No. 6. pp. 428-33.

Bibtex

@article{79d8afc11f5045088f17bbfe0502300c,
title = "Amniotic fluid MMP-9 and neurotrophins in autism spectrum disorders: an exploratory study",
abstract = "Evidence suggests that some developmental disorders, such as autism spectrum disorders (ASDs), are caused by errors in brain plasticity. Given the important role of matrix metalloproteinases (MMPs) and neurotrophins (NTs) in neuroplasticity, amniotic fluid samples for 331 ASD cases and 698 frequency-matched controls were analyzed for levels of MMP-9, brain-derived neurotrophic factor, NT-4 and transforming growth factor-{\ss} utilizing a Danish historic birth cohort and Danish nationwide health registers. Laboratory measurements were performed using an in-house multiplex sandwich immunoassay Luminex xMAP method, and measurements were analyzed using tobit and logistic regression. Results showed elevated levels of MMP-9 in ASD cases compared with controls (crude and adjusted tobit regression P-values: 0.01 and 0.06). Our results highlight the importance of exploring the biologic impact of MMP-9 and potential therapeutic roles of its inhibitors in ASD and may indicate that neuroplastic impairments in ASD may present during pregnancy.",
author = "Morsi Abdallah and Pearce, {Brad D} and Nanna Larsen and Kirstin Greaves-Lord and Bent N{\o}rgaard-Pedersen and Hougaard, {David M} and Mortensen, {Erik L} and Jakob Grove",
note = "{\textcopyright} 2012 International Society for Autism Research, Wiley Periodicals, Inc.",
year = "2012",
month = dec,
doi = "10.1002/aur.1254",
language = "English",
volume = "5",
pages = "428--33",
journal = "Autism Research",
issn = "1939-3792",
publisher = "Wiley",
number = "6",

}

RIS

TY - JOUR

T1 - Amniotic fluid MMP-9 and neurotrophins in autism spectrum disorders

T2 - an exploratory study

AU - Abdallah, Morsi

AU - Pearce, Brad D

AU - Larsen, Nanna

AU - Greaves-Lord, Kirstin

AU - Nørgaard-Pedersen, Bent

AU - Hougaard, David M

AU - Mortensen, Erik L

AU - Grove, Jakob

N1 - © 2012 International Society for Autism Research, Wiley Periodicals, Inc.

PY - 2012/12

Y1 - 2012/12

N2 - Evidence suggests that some developmental disorders, such as autism spectrum disorders (ASDs), are caused by errors in brain plasticity. Given the important role of matrix metalloproteinases (MMPs) and neurotrophins (NTs) in neuroplasticity, amniotic fluid samples for 331 ASD cases and 698 frequency-matched controls were analyzed for levels of MMP-9, brain-derived neurotrophic factor, NT-4 and transforming growth factor-ß utilizing a Danish historic birth cohort and Danish nationwide health registers. Laboratory measurements were performed using an in-house multiplex sandwich immunoassay Luminex xMAP method, and measurements were analyzed using tobit and logistic regression. Results showed elevated levels of MMP-9 in ASD cases compared with controls (crude and adjusted tobit regression P-values: 0.01 and 0.06). Our results highlight the importance of exploring the biologic impact of MMP-9 and potential therapeutic roles of its inhibitors in ASD and may indicate that neuroplastic impairments in ASD may present during pregnancy.

AB - Evidence suggests that some developmental disorders, such as autism spectrum disorders (ASDs), are caused by errors in brain plasticity. Given the important role of matrix metalloproteinases (MMPs) and neurotrophins (NTs) in neuroplasticity, amniotic fluid samples for 331 ASD cases and 698 frequency-matched controls were analyzed for levels of MMP-9, brain-derived neurotrophic factor, NT-4 and transforming growth factor-ß utilizing a Danish historic birth cohort and Danish nationwide health registers. Laboratory measurements were performed using an in-house multiplex sandwich immunoassay Luminex xMAP method, and measurements were analyzed using tobit and logistic regression. Results showed elevated levels of MMP-9 in ASD cases compared with controls (crude and adjusted tobit regression P-values: 0.01 and 0.06). Our results highlight the importance of exploring the biologic impact of MMP-9 and potential therapeutic roles of its inhibitors in ASD and may indicate that neuroplastic impairments in ASD may present during pregnancy.

U2 - 10.1002/aur.1254

DO - 10.1002/aur.1254

M3 - Journal article

C2 - 23008271

VL - 5

SP - 428

EP - 433

JO - Autism Research

JF - Autism Research

SN - 1939-3792

IS - 6

ER -

ID: 44583147