Antifungal metabolites from fungal endophytes of Pinus strobus

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Antifungal metabolites from fungal endophytes of Pinus strobus. / Sumarah, Mark W; Kesting, Julie R; Sørensen, Dan; Miller, J David.

In: Phytochemistry, Vol. 72, No. 14-15, 01.10.2011, p. 1833-1837.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Sumarah, MW, Kesting, JR, Sørensen, D & Miller, JD 2011, 'Antifungal metabolites from fungal endophytes of Pinus strobus', Phytochemistry, vol. 72, no. 14-15, pp. 1833-1837. https://doi.org/10.1016/j.phytochem.2011.05.003

APA

Sumarah, M. W., Kesting, J. R., Sørensen, D., & Miller, J. D. (2011). Antifungal metabolites from fungal endophytes of Pinus strobus. Phytochemistry, 72(14-15), 1833-1837. https://doi.org/10.1016/j.phytochem.2011.05.003

Vancouver

Sumarah MW, Kesting JR, Sørensen D, Miller JD. Antifungal metabolites from fungal endophytes of Pinus strobus. Phytochemistry. 2011 Oct 1;72(14-15):1833-1837. https://doi.org/10.1016/j.phytochem.2011.05.003

Author

Sumarah, Mark W ; Kesting, Julie R ; Sørensen, Dan ; Miller, J David. / Antifungal metabolites from fungal endophytes of Pinus strobus. In: Phytochemistry. 2011 ; Vol. 72, No. 14-15. pp. 1833-1837.

Bibtex

@article{9f6391060e234b80ba977dd358b92ac2,
title = "Antifungal metabolites from fungal endophytes of Pinus strobus",
abstract = "The extracts of five foliar fungal endophytes isolated from Pinus strobus (eastern white pine) that showed antifungal activity in disc diffusion assays were selected for further study. From these strains, the aliphatic polyketide compound 1 and three related sesquiterpenes 2-4 were isolated and characterized. Compound 2 is reported for the first time as a natural product and the E/Z conformational isomers 3 and 4 were hitherto unknown. Additionally, the three known macrolides; pyrenophorol (5), dihydropyrenophorin (6), and pyrenophorin (7) were isolated and identified. Their structures were elucidated by spectroscopic analyses including 2D NMR, HRMS and by comparison to literature data where available. The isolated compounds 1, 2, and 5 were antifungal against both the rust Microbotryum violaceum and Saccharomyces cerevisae.",
keywords = "Former Faculty of Pharmaceutical Sciences",
author = "Sumarah, {Mark W} and Kesting, {Julie R} and Dan S{\o}rensen and Miller, {J David}",
note = "Keywords: Eastern white pine; Pinus strobus; Pinaceae; Cronartium ribicola; Microbotryum violaceum; Endophyte; LC-MS-SPE/NMR",
year = "2011",
month = "10",
day = "1",
doi = "10.1016/j.phytochem.2011.05.003",
language = "English",
volume = "72",
pages = "1833--1837",
journal = "Phytochemistry",
issn = "0031-9422",
publisher = "Pergamon Press",
number = "14-15",

}

RIS

TY - JOUR

T1 - Antifungal metabolites from fungal endophytes of Pinus strobus

AU - Sumarah, Mark W

AU - Kesting, Julie R

AU - Sørensen, Dan

AU - Miller, J David

N1 - Keywords: Eastern white pine; Pinus strobus; Pinaceae; Cronartium ribicola; Microbotryum violaceum; Endophyte; LC-MS-SPE/NMR

PY - 2011/10/1

Y1 - 2011/10/1

N2 - The extracts of five foliar fungal endophytes isolated from Pinus strobus (eastern white pine) that showed antifungal activity in disc diffusion assays were selected for further study. From these strains, the aliphatic polyketide compound 1 and three related sesquiterpenes 2-4 were isolated and characterized. Compound 2 is reported for the first time as a natural product and the E/Z conformational isomers 3 and 4 were hitherto unknown. Additionally, the three known macrolides; pyrenophorol (5), dihydropyrenophorin (6), and pyrenophorin (7) were isolated and identified. Their structures were elucidated by spectroscopic analyses including 2D NMR, HRMS and by comparison to literature data where available. The isolated compounds 1, 2, and 5 were antifungal against both the rust Microbotryum violaceum and Saccharomyces cerevisae.

AB - The extracts of five foliar fungal endophytes isolated from Pinus strobus (eastern white pine) that showed antifungal activity in disc diffusion assays were selected for further study. From these strains, the aliphatic polyketide compound 1 and three related sesquiterpenes 2-4 were isolated and characterized. Compound 2 is reported for the first time as a natural product and the E/Z conformational isomers 3 and 4 were hitherto unknown. Additionally, the three known macrolides; pyrenophorol (5), dihydropyrenophorin (6), and pyrenophorin (7) were isolated and identified. Their structures were elucidated by spectroscopic analyses including 2D NMR, HRMS and by comparison to literature data where available. The isolated compounds 1, 2, and 5 were antifungal against both the rust Microbotryum violaceum and Saccharomyces cerevisae.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1016/j.phytochem.2011.05.003

DO - 10.1016/j.phytochem.2011.05.003

M3 - Journal article

C2 - 21632082

VL - 72

SP - 1833

EP - 1837

JO - Phytochemistry

JF - Phytochemistry

SN - 0031-9422

IS - 14-15

ER -

ID: 35410668