Assessment of Attention Deficits in Adolescent Offspring Exposed to Maternal Type 1 Diabetes
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Assessment of Attention Deficits in Adolescent Offspring Exposed to Maternal Type 1 Diabetes. / Bytoft, Birgitte; Knorr, Sine; Vlachova, Zuzana; Jensen, Rikke B.; Mathiesen, Elisabeth R.; Beck-Nielsen, Henning; Gravholt, Claus H.; Jensen, Dorte M.; Clausen, Tine D.; Mortensen, Erik L.; Damm, Peter.
In: PLOS ONE, Vol. 12, No. 1, e0169308, 10.01.2017.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Assessment of Attention Deficits in Adolescent Offspring Exposed to Maternal Type 1 Diabetes
AU - Bytoft, Birgitte
AU - Knorr, Sine
AU - Vlachova, Zuzana
AU - Jensen, Rikke B.
AU - Mathiesen, Elisabeth R.
AU - Beck-Nielsen, Henning
AU - Gravholt, Claus H.
AU - Jensen, Dorte M.
AU - Clausen, Tine D.
AU - Mortensen, Erik L.
AU - Damm, Peter
PY - 2017/1/10
Y1 - 2017/1/10
N2 - Objective: The aim of this study was to examine the potential association between intrauterine exposure to maternal diabetes and attention deficits in the offspring.Research design and methods: Adolescent offspring of a prospectively followed cohort of women with type 1 diabetes (n = 269) and a control group from the background population (n = 293) participated in a follow-up assessment in 2012–2013. We used scores from Conners Continuous Performance Test II to assess attention and based on a principal component analysis we evaluated scores on five different attention factors: focused attention, vigilance, hyperactivity/impulsivity, sustained attention and response style.Results: A higher frequency of the exposed offspring had a parent/self-reported use of Attention Deficit Hyperactivity Disorder (ADHD) medication compared to the control group (2.2% vs. 0.0%, p = 0.01). Clinical significant differences between adolescents exposed to maternal diabetes and unexposed controls were not found in either single scores on Conners Continuous Performance Test or on any of the five attention factors identified.Conclusions: Exposure to maternal type 1 diabetes did not seem to increase the risk of attention deficits in the adolescent offspring. However, a higher self-reported use of ADHD medication in the exposed group could suggest a difference in attention not revealed by the applied test.
AB - Objective: The aim of this study was to examine the potential association between intrauterine exposure to maternal diabetes and attention deficits in the offspring.Research design and methods: Adolescent offspring of a prospectively followed cohort of women with type 1 diabetes (n = 269) and a control group from the background population (n = 293) participated in a follow-up assessment in 2012–2013. We used scores from Conners Continuous Performance Test II to assess attention and based on a principal component analysis we evaluated scores on five different attention factors: focused attention, vigilance, hyperactivity/impulsivity, sustained attention and response style.Results: A higher frequency of the exposed offspring had a parent/self-reported use of Attention Deficit Hyperactivity Disorder (ADHD) medication compared to the control group (2.2% vs. 0.0%, p = 0.01). Clinical significant differences between adolescents exposed to maternal diabetes and unexposed controls were not found in either single scores on Conners Continuous Performance Test or on any of the five attention factors identified.Conclusions: Exposure to maternal type 1 diabetes did not seem to increase the risk of attention deficits in the adolescent offspring. However, a higher self-reported use of ADHD medication in the exposed group could suggest a difference in attention not revealed by the applied test.
U2 - 10.1371/journal.pone.0169308
DO - 10.1371/journal.pone.0169308
M3 - Journal article
C2 - 28072839
VL - 12
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 1
M1 - e0169308
ER -
ID: 173127853