Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study

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Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study. / van der Spoel, Evie; Rozing, Maarten P; Houwing-Duistermaat, Jeanine J; Slagboom, P Eline; Beekman, Marian; de Craen, Anton J M; Westendorp, Rudi G J; van Heemst, Diana.

In: Aging, Vol. 7, No. 11, PMC4694065, 12.11.2015, p. 956–963.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

van der Spoel, E, Rozing, MP, Houwing-Duistermaat, JJ, Slagboom, PE, Beekman, M, de Craen, AJM, Westendorp, RGJ & van Heemst, D 2015, 'Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study', Aging, vol. 7, no. 11, PMC4694065, pp. 956–963. <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694065/>

APA

van der Spoel, E., Rozing, M. P., Houwing-Duistermaat, J. J., Slagboom, P. E., Beekman, M., de Craen, A. J. M., Westendorp, R. G. J., & van Heemst, D. (2015). Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study. Aging, 7(11), 956–963. [PMC4694065]. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694065/

Vancouver

van der Spoel E, Rozing MP, Houwing-Duistermaat JJ, Slagboom PE, Beekman M, de Craen AJM et al. Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study. Aging. 2015 Nov 12;7(11):956–963. PMC4694065.

Author

van der Spoel, Evie ; Rozing, Maarten P ; Houwing-Duistermaat, Jeanine J ; Slagboom, P Eline ; Beekman, Marian ; de Craen, Anton J M ; Westendorp, Rudi G J ; van Heemst, Diana. / Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study. In: Aging. 2015 ; Vol. 7, No. 11. pp. 956–963.

Bibtex

@article{061d7151474d475ca98b3f68f7477666,
title = "Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study",
abstract = "Reduced insulin/insulin-like growth factor 1 (IGF-1) signaling has been associated with longevity in various model organisms. However, the role of insulin/IGF-1 signaling in human survival remains controversial. The aim of this study was to test whether circulating IGF-1 axis parameters associate with old age survival and functional status in nonagenarians from the Leiden Longevity Study. This study examined 858 Dutch nonagenarian (males≥89 years; females≥91 years) siblings from 409 families, without selection on health or demographic characteristics. Nonagenarians were divided over sex-specific strata according to their levels of IGF-1, IGF binding protein 3 and IGF-1/IGFBP3 molar ratio. We found that lower IGF-1/IGFBP3 ratios were associated with improved survival: nonagenarians in the quartile of the lowest ratio had a lower estimated hazard ratio (95% confidence interval) of 0.73 (0.59 - 0.91) compared to the quartile with the highest ratio (ptrend=0.002). Functional status was assessed by (Instrumental) Activities of Daily Living ((I)ADL) scales. Compared to those in the quartile with the highest IGF-1/IGFBP3 ratio, nonagenarians in the lowest quartile had higher scores for ADL (ptrend=0.001) and IADL (ptrend=0.003). These findings suggest that IGF-1 axis parameters are associated with increased old age survival and better functional status in nonagenarians from the Leiden Longevity Study.",
author = "{van der Spoel}, Evie and Rozing, {Maarten P} and Houwing-Duistermaat, {Jeanine J} and Slagboom, {P Eline} and Marian Beekman and {de Craen}, {Anton J M} and Westendorp, {Rudi G J} and {van Heemst}, Diana",
year = "2015",
month = nov,
day = "12",
language = "English",
volume = "7",
pages = "956–963",
journal = "Aging",
issn = "1945-4589",
publisher = "Impact Journals LLC",
number = "11",

}

RIS

TY - JOUR

T1 - Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study

AU - van der Spoel, Evie

AU - Rozing, Maarten P

AU - Houwing-Duistermaat, Jeanine J

AU - Slagboom, P Eline

AU - Beekman, Marian

AU - de Craen, Anton J M

AU - Westendorp, Rudi G J

AU - van Heemst, Diana

PY - 2015/11/12

Y1 - 2015/11/12

N2 - Reduced insulin/insulin-like growth factor 1 (IGF-1) signaling has been associated with longevity in various model organisms. However, the role of insulin/IGF-1 signaling in human survival remains controversial. The aim of this study was to test whether circulating IGF-1 axis parameters associate with old age survival and functional status in nonagenarians from the Leiden Longevity Study. This study examined 858 Dutch nonagenarian (males≥89 years; females≥91 years) siblings from 409 families, without selection on health or demographic characteristics. Nonagenarians were divided over sex-specific strata according to their levels of IGF-1, IGF binding protein 3 and IGF-1/IGFBP3 molar ratio. We found that lower IGF-1/IGFBP3 ratios were associated with improved survival: nonagenarians in the quartile of the lowest ratio had a lower estimated hazard ratio (95% confidence interval) of 0.73 (0.59 - 0.91) compared to the quartile with the highest ratio (ptrend=0.002). Functional status was assessed by (Instrumental) Activities of Daily Living ((I)ADL) scales. Compared to those in the quartile with the highest IGF-1/IGFBP3 ratio, nonagenarians in the lowest quartile had higher scores for ADL (ptrend=0.001) and IADL (ptrend=0.003). These findings suggest that IGF-1 axis parameters are associated with increased old age survival and better functional status in nonagenarians from the Leiden Longevity Study.

AB - Reduced insulin/insulin-like growth factor 1 (IGF-1) signaling has been associated with longevity in various model organisms. However, the role of insulin/IGF-1 signaling in human survival remains controversial. The aim of this study was to test whether circulating IGF-1 axis parameters associate with old age survival and functional status in nonagenarians from the Leiden Longevity Study. This study examined 858 Dutch nonagenarian (males≥89 years; females≥91 years) siblings from 409 families, without selection on health or demographic characteristics. Nonagenarians were divided over sex-specific strata according to their levels of IGF-1, IGF binding protein 3 and IGF-1/IGFBP3 molar ratio. We found that lower IGF-1/IGFBP3 ratios were associated with improved survival: nonagenarians in the quartile of the lowest ratio had a lower estimated hazard ratio (95% confidence interval) of 0.73 (0.59 - 0.91) compared to the quartile with the highest ratio (ptrend=0.002). Functional status was assessed by (Instrumental) Activities of Daily Living ((I)ADL) scales. Compared to those in the quartile with the highest IGF-1/IGFBP3 ratio, nonagenarians in the lowest quartile had higher scores for ADL (ptrend=0.001) and IADL (ptrend=0.003). These findings suggest that IGF-1 axis parameters are associated with increased old age survival and better functional status in nonagenarians from the Leiden Longevity Study.

M3 - Journal article

C2 - 26568155

VL - 7

SP - 956

EP - 963

JO - Aging

JF - Aging

SN - 1945-4589

IS - 11

M1 - PMC4694065

ER -

ID: 151344570