Associations between ambient air pollution and noise from road traffic with blood pressure and insulin resistance in children from Denmark

Research output: Contribution to journalJournal articlepeer-review

Standard

Associations between ambient air pollution and noise from road traffic with blood pressure and insulin resistance in children from Denmark. / Pedersen, Marie; Halldorsson, Thorhallur I; Ketzel, Matthias; Grandström, Charlotta; Raaschou-Nielsen, Ole; Jensen, Steen S; Grunnet, Louise G; Vaag, Allan; Sørensen, Mette; Olsen, Sjurdur F.

In: Environmental epidemiology (Philadelphia, Pa.), Vol. 3, No. 5, 2019, p. e069.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Pedersen, M, Halldorsson, TI, Ketzel, M, Grandström, C, Raaschou-Nielsen, O, Jensen, SS, Grunnet, LG, Vaag, A, Sørensen, M & Olsen, SF 2019, 'Associations between ambient air pollution and noise from road traffic with blood pressure and insulin resistance in children from Denmark', Environmental epidemiology (Philadelphia, Pa.), vol. 3, no. 5, pp. e069. https://doi.org/10.1097/EE9.0000000000000069

APA

Pedersen, M., Halldorsson, T. I., Ketzel, M., Grandström, C., Raaschou-Nielsen, O., Jensen, S. S., Grunnet, L. G., Vaag, A., Sørensen, M., & Olsen, S. F. (2019). Associations between ambient air pollution and noise from road traffic with blood pressure and insulin resistance in children from Denmark. Environmental epidemiology (Philadelphia, Pa.), 3(5), e069. https://doi.org/10.1097/EE9.0000000000000069

Vancouver

Pedersen M, Halldorsson TI, Ketzel M, Grandström C, Raaschou-Nielsen O, Jensen SS et al. Associations between ambient air pollution and noise from road traffic with blood pressure and insulin resistance in children from Denmark. Environmental epidemiology (Philadelphia, Pa.). 2019;3(5):e069. https://doi.org/10.1097/EE9.0000000000000069

Author

Pedersen, Marie ; Halldorsson, Thorhallur I ; Ketzel, Matthias ; Grandström, Charlotta ; Raaschou-Nielsen, Ole ; Jensen, Steen S ; Grunnet, Louise G ; Vaag, Allan ; Sørensen, Mette ; Olsen, Sjurdur F. / Associations between ambient air pollution and noise from road traffic with blood pressure and insulin resistance in children from Denmark. In: Environmental epidemiology (Philadelphia, Pa.). 2019 ; Vol. 3, No. 5. pp. e069.

Bibtex

@article{5ab39f16a51a4d6e92ebd98472a5c832,
title = "Associations between ambient air pollution and noise from road traffic with blood pressure and insulin resistance in children from Denmark",
abstract = "BACKGROUND: Road traffic is a major source of air pollution and noise. Both exposures may contribute to increased blood pressure and metabolic disease; however, few studies have examined these relationships in children.OBJECTIVES: We aimed to investigate whether long-term exposures to air pollution and noise from road traffic were associated with increased blood pressure and insulin resistance in children.METHODS: Cardiometabolic outcomes were derived from a follow-up examination of 629 children (10-15 years old) enrolled in the Danish National Birth Cohort. We evaluated associations with prenatal and postnatal residential exposure to nitrogen dioxide (NO2) and noise from road traffic (Lden) using historical addresses and linear regression models.RESULTS: A 10-unit increase in postnatal exposure to NO2 and Lden was associated with a 0.31 (-0.87, 1.48) and 0.18 (-0.61, 0.96) mmHg changes in diastolic blood pressure, respectively. In contrast, both exposures were associated with decreased systolic blood pressure. After adjustment and mutual adjustment for NO2, exposure to Lden was associated with a statistical significant decrease in systolic blood pressure both during prenatal and postnatal life, but the majority of the associations evaluated did not reach statistical significance. Inverse associations were observed for plasma fasting glucose, insulin, and HOMA of insulin resistance for both exposures, exposure windows, before and after adjustment.CONCLUSIONS: The findings do not support evidence of associations between long-term exposures to air pollution and road traffic noise, increased blood pressure, and a metabolic profile characteristic of increased risk for glucose intolerance or type 2 diabetes later in life.",
author = "Marie Pedersen and Halldorsson, {Thorhallur I} and Matthias Ketzel and Charlotta Grandstr{\"o}m and Ole Raaschou-Nielsen and Jensen, {Steen S} and Grunnet, {Louise G} and Allan Vaag and Mette S{\o}rensen and Olsen, {Sjurdur F}",
note = "Copyright {\textcopyright} 2019 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of Environmental Epidemiology. All rights reserved.",
year = "2019",
doi = "10.1097/EE9.0000000000000069",
language = "English",
volume = "3",
pages = "e069",
journal = "Environmental Epidemiology",
issn = "2474-7882",
publisher = "Lippincott, Williams & Wilkins",
number = "5",

}

RIS

TY - JOUR

T1 - Associations between ambient air pollution and noise from road traffic with blood pressure and insulin resistance in children from Denmark

AU - Pedersen, Marie

AU - Halldorsson, Thorhallur I

AU - Ketzel, Matthias

AU - Grandström, Charlotta

AU - Raaschou-Nielsen, Ole

AU - Jensen, Steen S

AU - Grunnet, Louise G

AU - Vaag, Allan

AU - Sørensen, Mette

AU - Olsen, Sjurdur F

N1 - Copyright © 2019 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of Environmental Epidemiology. All rights reserved.

PY - 2019

Y1 - 2019

N2 - BACKGROUND: Road traffic is a major source of air pollution and noise. Both exposures may contribute to increased blood pressure and metabolic disease; however, few studies have examined these relationships in children.OBJECTIVES: We aimed to investigate whether long-term exposures to air pollution and noise from road traffic were associated with increased blood pressure and insulin resistance in children.METHODS: Cardiometabolic outcomes were derived from a follow-up examination of 629 children (10-15 years old) enrolled in the Danish National Birth Cohort. We evaluated associations with prenatal and postnatal residential exposure to nitrogen dioxide (NO2) and noise from road traffic (Lden) using historical addresses and linear regression models.RESULTS: A 10-unit increase in postnatal exposure to NO2 and Lden was associated with a 0.31 (-0.87, 1.48) and 0.18 (-0.61, 0.96) mmHg changes in diastolic blood pressure, respectively. In contrast, both exposures were associated with decreased systolic blood pressure. After adjustment and mutual adjustment for NO2, exposure to Lden was associated with a statistical significant decrease in systolic blood pressure both during prenatal and postnatal life, but the majority of the associations evaluated did not reach statistical significance. Inverse associations were observed for plasma fasting glucose, insulin, and HOMA of insulin resistance for both exposures, exposure windows, before and after adjustment.CONCLUSIONS: The findings do not support evidence of associations between long-term exposures to air pollution and road traffic noise, increased blood pressure, and a metabolic profile characteristic of increased risk for glucose intolerance or type 2 diabetes later in life.

AB - BACKGROUND: Road traffic is a major source of air pollution and noise. Both exposures may contribute to increased blood pressure and metabolic disease; however, few studies have examined these relationships in children.OBJECTIVES: We aimed to investigate whether long-term exposures to air pollution and noise from road traffic were associated with increased blood pressure and insulin resistance in children.METHODS: Cardiometabolic outcomes were derived from a follow-up examination of 629 children (10-15 years old) enrolled in the Danish National Birth Cohort. We evaluated associations with prenatal and postnatal residential exposure to nitrogen dioxide (NO2) and noise from road traffic (Lden) using historical addresses and linear regression models.RESULTS: A 10-unit increase in postnatal exposure to NO2 and Lden was associated with a 0.31 (-0.87, 1.48) and 0.18 (-0.61, 0.96) mmHg changes in diastolic blood pressure, respectively. In contrast, both exposures were associated with decreased systolic blood pressure. After adjustment and mutual adjustment for NO2, exposure to Lden was associated with a statistical significant decrease in systolic blood pressure both during prenatal and postnatal life, but the majority of the associations evaluated did not reach statistical significance. Inverse associations were observed for plasma fasting glucose, insulin, and HOMA of insulin resistance for both exposures, exposure windows, before and after adjustment.CONCLUSIONS: The findings do not support evidence of associations between long-term exposures to air pollution and road traffic noise, increased blood pressure, and a metabolic profile characteristic of increased risk for glucose intolerance or type 2 diabetes later in life.

U2 - 10.1097/EE9.0000000000000069

DO - 10.1097/EE9.0000000000000069

M3 - Journal article

C2 - 33778342

VL - 3

SP - e069

JO - Environmental Epidemiology

JF - Environmental Epidemiology

SN - 2474-7882

IS - 5

ER -

ID: 306527740