Associations between Fatigue, Physical Activity, and QoL in Patients with Myeloproliferative Neoplasms

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Associations between Fatigue, Physical Activity, and QoL in Patients with Myeloproliferative Neoplasms. / Tolstrup Larsen, Rasmus; Tang, Lars Hermann; Brochmann, Nana; Meulengracht Flachs, Esben; Illemann Christensen, Anne; Hasselbalch, Hans Carl; Zwisler, Ann-Dorthe.

In: European Journal of Haematology, Vol. 100, No. 6, 2018, p. 550-559.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Tolstrup Larsen, R, Tang, LH, Brochmann, N, Meulengracht Flachs, E, Illemann Christensen, A, Hasselbalch, HC & Zwisler, A-D 2018, 'Associations between Fatigue, Physical Activity, and QoL in Patients with Myeloproliferative Neoplasms', European Journal of Haematology, vol. 100, no. 6, pp. 550-559. https://doi.org/10.1111/ejh.13048

APA

Tolstrup Larsen, R., Tang, L. H., Brochmann, N., Meulengracht Flachs, E., Illemann Christensen, A., Hasselbalch, H. C., & Zwisler, A-D. (2018). Associations between Fatigue, Physical Activity, and QoL in Patients with Myeloproliferative Neoplasms. European Journal of Haematology, 100(6), 550-559. https://doi.org/10.1111/ejh.13048

Vancouver

Tolstrup Larsen R, Tang LH, Brochmann N, Meulengracht Flachs E, Illemann Christensen A, Hasselbalch HC et al. Associations between Fatigue, Physical Activity, and QoL in Patients with Myeloproliferative Neoplasms. European Journal of Haematology. 2018;100(6):550-559. https://doi.org/10.1111/ejh.13048

Author

Tolstrup Larsen, Rasmus ; Tang, Lars Hermann ; Brochmann, Nana ; Meulengracht Flachs, Esben ; Illemann Christensen, Anne ; Hasselbalch, Hans Carl ; Zwisler, Ann-Dorthe. / Associations between Fatigue, Physical Activity, and QoL in Patients with Myeloproliferative Neoplasms. In: European Journal of Haematology. 2018 ; Vol. 100, No. 6. pp. 550-559.

Bibtex

@article{307fa26135694bbe8beccd6473661451,
title = "Associations between Fatigue, Physical Activity, and QoL in Patients with Myeloproliferative Neoplasms",
abstract = "BACKGROUND: Patients with Philadelphia-chromosome negative Myeloproliferative Neoplasms (MPNs) report fatigue as the most common symptom and contributing significantly to reduction in their Quality of Life (QoL). Targeted non-pharmacological intervention to increase levels of physical activity is suggested as a fatigue-reducing and QoL-enhancing intervention in MPN patients. The interrelationship between physical activity, fatigue, and QoL have, to our knowledge, never been reported.METHODS: We analyzed data from 1,807 MPN patients. The primary analysis included a multiple regression model allowing fatigue to mediate the relationship between physical activity and QoL.RESULTS: We herein report the first and the largest study of patients with MPNs, in whom we have investigated the interrelationship between fatigue, physical activity, and QoL. Sedentary patients were more likely to report fatigue compared to highly active patients. There was a negative association between fatigue and QoL and there was a positive association between physical activity and QoL. There was no interaction between fatigue and physical activity in the association with QoL.CONCLUSION: We found positive associations between level of physical activity and QoL, independently of fatigue being present. More research is needed before physical activity can be introduced as a targeted intervention to reduce fatigue and increase QoL in the management of patients. This article is protected by copyright. All rights reserved.",
author = "{Tolstrup Larsen}, Rasmus and Tang, {Lars Hermann} and Nana Brochmann and {Meulengracht Flachs}, Esben and {Illemann Christensen}, Anne and Hasselbalch, {Hans Carl} and Ann-Dorthe Zwisler",
note = "This article is protected by copyright. All rights reserved.",
year = "2018",
doi = "10.1111/ejh.13048",
language = "English",
volume = "100",
pages = "550--559",
journal = "European Journal of Haematology",
issn = "0902-4441",
publisher = "Wiley-Blackwell",
number = "6",

}

RIS

TY - JOUR

T1 - Associations between Fatigue, Physical Activity, and QoL in Patients with Myeloproliferative Neoplasms

AU - Tolstrup Larsen, Rasmus

AU - Tang, Lars Hermann

AU - Brochmann, Nana

AU - Meulengracht Flachs, Esben

AU - Illemann Christensen, Anne

AU - Hasselbalch, Hans Carl

AU - Zwisler, Ann-Dorthe

N1 - This article is protected by copyright. All rights reserved.

PY - 2018

Y1 - 2018

N2 - BACKGROUND: Patients with Philadelphia-chromosome negative Myeloproliferative Neoplasms (MPNs) report fatigue as the most common symptom and contributing significantly to reduction in their Quality of Life (QoL). Targeted non-pharmacological intervention to increase levels of physical activity is suggested as a fatigue-reducing and QoL-enhancing intervention in MPN patients. The interrelationship between physical activity, fatigue, and QoL have, to our knowledge, never been reported.METHODS: We analyzed data from 1,807 MPN patients. The primary analysis included a multiple regression model allowing fatigue to mediate the relationship between physical activity and QoL.RESULTS: We herein report the first and the largest study of patients with MPNs, in whom we have investigated the interrelationship between fatigue, physical activity, and QoL. Sedentary patients were more likely to report fatigue compared to highly active patients. There was a negative association between fatigue and QoL and there was a positive association between physical activity and QoL. There was no interaction between fatigue and physical activity in the association with QoL.CONCLUSION: We found positive associations between level of physical activity and QoL, independently of fatigue being present. More research is needed before physical activity can be introduced as a targeted intervention to reduce fatigue and increase QoL in the management of patients. This article is protected by copyright. All rights reserved.

AB - BACKGROUND: Patients with Philadelphia-chromosome negative Myeloproliferative Neoplasms (MPNs) report fatigue as the most common symptom and contributing significantly to reduction in their Quality of Life (QoL). Targeted non-pharmacological intervention to increase levels of physical activity is suggested as a fatigue-reducing and QoL-enhancing intervention in MPN patients. The interrelationship between physical activity, fatigue, and QoL have, to our knowledge, never been reported.METHODS: We analyzed data from 1,807 MPN patients. The primary analysis included a multiple regression model allowing fatigue to mediate the relationship between physical activity and QoL.RESULTS: We herein report the first and the largest study of patients with MPNs, in whom we have investigated the interrelationship between fatigue, physical activity, and QoL. Sedentary patients were more likely to report fatigue compared to highly active patients. There was a negative association between fatigue and QoL and there was a positive association between physical activity and QoL. There was no interaction between fatigue and physical activity in the association with QoL.CONCLUSION: We found positive associations between level of physical activity and QoL, independently of fatigue being present. More research is needed before physical activity can be introduced as a targeted intervention to reduce fatigue and increase QoL in the management of patients. This article is protected by copyright. All rights reserved.

U2 - 10.1111/ejh.13048

DO - 10.1111/ejh.13048

M3 - Journal article

VL - 100

SP - 550

EP - 559

JO - European Journal of Haematology

JF - European Journal of Haematology

SN - 0902-4441

IS - 6

ER -

ID: 192047690