Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults

Research output: Contribution to journalJournal articlepeer-review

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Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults. / Chen, Sijia; Pawelec, Graham; Trompet, Stella; Goldeck, David; Mortensen, Laust H.; Slagboom, P. Eline; Christensen, Kaare; Gussekloo, Jacobijn; Kearney, Patricia; Buckley, Brendan M.; Ford, Ian; Jukema, J. Wouter; Westendorp, Rudi G.J.; Maier, Andrea B.

In: The Journal of Infectious Diseases, Vol. 223, No. 2, 2021, p. 238-246.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Chen, S, Pawelec, G, Trompet, S, Goldeck, D, Mortensen, LH, Slagboom, PE, Christensen, K, Gussekloo, J, Kearney, P, Buckley, BM, Ford, I, Jukema, JW, Westendorp, RGJ & Maier, AB 2021, 'Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults', The Journal of Infectious Diseases, vol. 223, no. 2, pp. 238-246. https://doi.org/10.1093/infdis/jiaa480

APA

Chen, S., Pawelec, G., Trompet, S., Goldeck, D., Mortensen, L. H., Slagboom, P. E., Christensen, K., Gussekloo, J., Kearney, P., Buckley, B. M., Ford, I., Jukema, J. W., Westendorp, R. G. J., & Maier, A. B. (2021). Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults. The Journal of Infectious Diseases, 223(2), 238-246. https://doi.org/10.1093/infdis/jiaa480

Vancouver

Chen S, Pawelec G, Trompet S, Goldeck D, Mortensen LH, Slagboom PE et al. Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults. The Journal of Infectious Diseases. 2021;223(2):238-246. https://doi.org/10.1093/infdis/jiaa480

Author

Chen, Sijia ; Pawelec, Graham ; Trompet, Stella ; Goldeck, David ; Mortensen, Laust H. ; Slagboom, P. Eline ; Christensen, Kaare ; Gussekloo, Jacobijn ; Kearney, Patricia ; Buckley, Brendan M. ; Ford, Ian ; Jukema, J. Wouter ; Westendorp, Rudi G.J. ; Maier, Andrea B. / Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults. In: The Journal of Infectious Diseases. 2021 ; Vol. 223, No. 2. pp. 238-246.

Bibtex

@article{8c1723f40ab14629bbaf1683ad860359,
title = "Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults",
abstract = "BACKGROUND: Whether latent cytomegalovirus (CMV) infection in older adults has any substantial health consequences is unclear. Here, we sought associations between CMV-seropositivity and IgG titer with all-cause and cardiovascular mortality in 5 longitudinal cohorts. METHODS: Leiden Longevity Study, Prospective Study of Pravastatin in the Elderly at Risk, Longitudinal Study of Aging Danish Twins, and Leiden 85-plus Study were assessed at median (2.8-11.4 years) follow-up . Cox regression and random effects meta-analysis were used to estimate mortality risk dependent on CMV serostatus and/or IgG antibody titer, in quartiles after adjusting for confounders. RESULTS: CMV-seropositivity was seen in 47%-79% of 10 122 white community-dwelling adults aged 59-93 years. Of these, 3519 had died on follow-up (579 from cardiovascular disease). CMV seropositivity was not associated with all-cause (hazard ratio [HR], 1.05; 95% confidence interval [CI], .97-1.14) or cardiovascular mortality (HR, 0.97; 95% CI, .83-1.13). Subjects in the highest CMV IgG quartile group had increased all-cause mortality relative to CMV-seronegatives (HR, 1.16; 95% CI, 1.04-1.29) but this association lost significance after adjustment for confounders (HR, 1.13; 95% CI, .99-1.29). The lack of increased mortality risk was confirmed in subanalyses. CONCLUSIONS: CMV infection is not associated with all-cause or cardiovascular mortality in white community-dwelling older adults.",
keywords = "aged, cardiovascular, cytomegalovirus, Herpesviridae, immunoglobulin G, mortality, seroepidemiologic studies",
author = "Sijia Chen and Graham Pawelec and Stella Trompet and David Goldeck and Mortensen, {Laust H.} and Slagboom, {P. Eline} and Kaare Christensen and Jacobijn Gussekloo and Patricia Kearney and Buckley, {Brendan M.} and Ian Ford and Jukema, {J. Wouter} and Westendorp, {Rudi G.J.} and Maier, {Andrea B.}",
note = "Publisher Copyright: {\textcopyright} The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.",
year = "2021",
doi = "10.1093/infdis/jiaa480",
language = "English",
volume = "223",
pages = "238--246",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "2",

}

RIS

TY - JOUR

T1 - Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults

AU - Chen, Sijia

AU - Pawelec, Graham

AU - Trompet, Stella

AU - Goldeck, David

AU - Mortensen, Laust H.

AU - Slagboom, P. Eline

AU - Christensen, Kaare

AU - Gussekloo, Jacobijn

AU - Kearney, Patricia

AU - Buckley, Brendan M.

AU - Ford, Ian

AU - Jukema, J. Wouter

AU - Westendorp, Rudi G.J.

AU - Maier, Andrea B.

N1 - Publisher Copyright: © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.

PY - 2021

Y1 - 2021

N2 - BACKGROUND: Whether latent cytomegalovirus (CMV) infection in older adults has any substantial health consequences is unclear. Here, we sought associations between CMV-seropositivity and IgG titer with all-cause and cardiovascular mortality in 5 longitudinal cohorts. METHODS: Leiden Longevity Study, Prospective Study of Pravastatin in the Elderly at Risk, Longitudinal Study of Aging Danish Twins, and Leiden 85-plus Study were assessed at median (2.8-11.4 years) follow-up . Cox regression and random effects meta-analysis were used to estimate mortality risk dependent on CMV serostatus and/or IgG antibody titer, in quartiles after adjusting for confounders. RESULTS: CMV-seropositivity was seen in 47%-79% of 10 122 white community-dwelling adults aged 59-93 years. Of these, 3519 had died on follow-up (579 from cardiovascular disease). CMV seropositivity was not associated with all-cause (hazard ratio [HR], 1.05; 95% confidence interval [CI], .97-1.14) or cardiovascular mortality (HR, 0.97; 95% CI, .83-1.13). Subjects in the highest CMV IgG quartile group had increased all-cause mortality relative to CMV-seronegatives (HR, 1.16; 95% CI, 1.04-1.29) but this association lost significance after adjustment for confounders (HR, 1.13; 95% CI, .99-1.29). The lack of increased mortality risk was confirmed in subanalyses. CONCLUSIONS: CMV infection is not associated with all-cause or cardiovascular mortality in white community-dwelling older adults.

AB - BACKGROUND: Whether latent cytomegalovirus (CMV) infection in older adults has any substantial health consequences is unclear. Here, we sought associations between CMV-seropositivity and IgG titer with all-cause and cardiovascular mortality in 5 longitudinal cohorts. METHODS: Leiden Longevity Study, Prospective Study of Pravastatin in the Elderly at Risk, Longitudinal Study of Aging Danish Twins, and Leiden 85-plus Study were assessed at median (2.8-11.4 years) follow-up . Cox regression and random effects meta-analysis were used to estimate mortality risk dependent on CMV serostatus and/or IgG antibody titer, in quartiles after adjusting for confounders. RESULTS: CMV-seropositivity was seen in 47%-79% of 10 122 white community-dwelling adults aged 59-93 years. Of these, 3519 had died on follow-up (579 from cardiovascular disease). CMV seropositivity was not associated with all-cause (hazard ratio [HR], 1.05; 95% confidence interval [CI], .97-1.14) or cardiovascular mortality (HR, 0.97; 95% CI, .83-1.13). Subjects in the highest CMV IgG quartile group had increased all-cause mortality relative to CMV-seronegatives (HR, 1.16; 95% CI, 1.04-1.29) but this association lost significance after adjustment for confounders (HR, 1.13; 95% CI, .99-1.29). The lack of increased mortality risk was confirmed in subanalyses. CONCLUSIONS: CMV infection is not associated with all-cause or cardiovascular mortality in white community-dwelling older adults.

KW - aged

KW - cardiovascular

KW - cytomegalovirus

KW - Herpesviridae

KW - immunoglobulin G

KW - mortality

KW - seroepidemiologic studies

U2 - 10.1093/infdis/jiaa480

DO - 10.1093/infdis/jiaa480

M3 - Journal article

C2 - 32909605

AN - SCOPUS:85102099025

VL - 223

SP - 238

EP - 246

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 2

ER -

ID: 269661510