Atherosclerosis and vasomotor dysfunction in arteries of animals after exposure to combustion-derived particulate matter or nanomaterials

Research output: Contribution to journalReviewpeer-review

Standard

Atherosclerosis and vasomotor dysfunction in arteries of animals after exposure to combustion-derived particulate matter or nanomaterials. / Møller, Peter; Christophersen, Daniel Vest; Raun Jacobsen, Nicklas; Skovmand, Astrid; Gouveia, Ana Cecilia Damiao; Guerra Andersen, Maria Helena; Kermanizadeh, Ali; Jensen, Ditte Marie; Danielsen, Pernille Høgh; Roursgaard, Martin; Jantzen, Kim; Loft, Steffen.

In: Critical Reviews in Toxicology, Vol. 46, No. 5, 05.2016, p. 437-476.

Research output: Contribution to journalReviewpeer-review

Harvard

Møller, P, Christophersen, DV, Raun Jacobsen, N, Skovmand, A, Gouveia, ACD, Guerra Andersen, MH, Kermanizadeh, A, Jensen, DM, Danielsen, PH, Roursgaard, M, Jantzen, K & Loft, S 2016, 'Atherosclerosis and vasomotor dysfunction in arteries of animals after exposure to combustion-derived particulate matter or nanomaterials', Critical Reviews in Toxicology, vol. 46, no. 5, pp. 437-476. https://doi.org/10.3109/10408444.2016.1149451

APA

Møller, P., Christophersen, D. V., Raun Jacobsen, N., Skovmand, A., Gouveia, A. C. D., Guerra Andersen, M. H., Kermanizadeh, A., Jensen, D. M., Danielsen, P. H., Roursgaard, M., Jantzen, K., & Loft, S. (2016). Atherosclerosis and vasomotor dysfunction in arteries of animals after exposure to combustion-derived particulate matter or nanomaterials. Critical Reviews in Toxicology, 46(5), 437-476. https://doi.org/10.3109/10408444.2016.1149451

Vancouver

Møller P, Christophersen DV, Raun Jacobsen N, Skovmand A, Gouveia ACD, Guerra Andersen MH et al. Atherosclerosis and vasomotor dysfunction in arteries of animals after exposure to combustion-derived particulate matter or nanomaterials. Critical Reviews in Toxicology. 2016 May;46(5):437-476. https://doi.org/10.3109/10408444.2016.1149451

Author

Møller, Peter ; Christophersen, Daniel Vest ; Raun Jacobsen, Nicklas ; Skovmand, Astrid ; Gouveia, Ana Cecilia Damiao ; Guerra Andersen, Maria Helena ; Kermanizadeh, Ali ; Jensen, Ditte Marie ; Danielsen, Pernille Høgh ; Roursgaard, Martin ; Jantzen, Kim ; Loft, Steffen. / Atherosclerosis and vasomotor dysfunction in arteries of animals after exposure to combustion-derived particulate matter or nanomaterials. In: Critical Reviews in Toxicology. 2016 ; Vol. 46, No. 5. pp. 437-476.

Bibtex

@article{3605c185befa4aaea97700fa946be05a,
title = "Atherosclerosis and vasomotor dysfunction in arteries of animals after exposure to combustion-derived particulate matter or nanomaterials",
abstract = "Exposure to particulate matter (PM) from traffic vehicles is hazardous to the vascular system, leading to clinical manifestations and mortality due to ischemic heart disease. By analogy, nanomaterials may also be associated with the same outcomes. Here, the effects of exposure to PM from ambient air, diesel exhaust and certain nanomaterials on atherosclerosis and vasomotor function in animals have been assessed. The majority of studies have used pulmonary exposure by inhalation or instillation, although there are some studies on non-pulmonary routes such as the gastrointestinal tract. Airway exposure to air pollution particles and nanomaterials is associated with similar effects on atherosclerosis progression, augmented vasoconstriction and blunted vasorelaxation responses in arteries, whereas exposure to diesel exhaust is associated with lower responses. At present, there is no convincing evidence of dose-dependent effects across studies. Oxidative stress and inflammation have been observed in the arterial wall of PM-exposed animals with vasomotor dysfunction or plaque progression. From the data, it is evident that pulmonary and systemic inflammation does not seem to be necessary for these vascular effects to occur. Furthermore, there is inconsistent evidence with regard to altered plasma lipid profile and systemic inflammation as a key step in vasomotor dysfunction and progression of atherosclerosis in PM-exposed animals. In summary, the results show that certain nanomaterials, including TiO2, carbon black and carbon nanotubes, have similar hazards to the vascular system as combustion-derived PM.",
keywords = "Air pollution, atherosclerosis, nanomaterials, particulate matter, vasomotor dysfunction",
author = "Peter M{\o}ller and Christophersen, {Daniel Vest} and {Raun Jacobsen}, Nicklas and Astrid Skovmand and Gouveia, {Ana Cecilia Damiao} and {Guerra Andersen}, {Maria Helena} and Ali Kermanizadeh and Jensen, {Ditte Marie} and Danielsen, {Pernille H{\o}gh} and Martin Roursgaard and Kim Jantzen and Steffen Loft",
year = "2016",
month = may,
doi = "10.3109/10408444.2016.1149451",
language = "English",
volume = "46",
pages = "437--476",
journal = "Critical Reviews in Toxicology",
issn = "1040-8444",
publisher = "Taylor & Francis",
number = "5",

}

RIS

TY - JOUR

T1 - Atherosclerosis and vasomotor dysfunction in arteries of animals after exposure to combustion-derived particulate matter or nanomaterials

AU - Møller, Peter

AU - Christophersen, Daniel Vest

AU - Raun Jacobsen, Nicklas

AU - Skovmand, Astrid

AU - Gouveia, Ana Cecilia Damiao

AU - Guerra Andersen, Maria Helena

AU - Kermanizadeh, Ali

AU - Jensen, Ditte Marie

AU - Danielsen, Pernille Høgh

AU - Roursgaard, Martin

AU - Jantzen, Kim

AU - Loft, Steffen

PY - 2016/5

Y1 - 2016/5

N2 - Exposure to particulate matter (PM) from traffic vehicles is hazardous to the vascular system, leading to clinical manifestations and mortality due to ischemic heart disease. By analogy, nanomaterials may also be associated with the same outcomes. Here, the effects of exposure to PM from ambient air, diesel exhaust and certain nanomaterials on atherosclerosis and vasomotor function in animals have been assessed. The majority of studies have used pulmonary exposure by inhalation or instillation, although there are some studies on non-pulmonary routes such as the gastrointestinal tract. Airway exposure to air pollution particles and nanomaterials is associated with similar effects on atherosclerosis progression, augmented vasoconstriction and blunted vasorelaxation responses in arteries, whereas exposure to diesel exhaust is associated with lower responses. At present, there is no convincing evidence of dose-dependent effects across studies. Oxidative stress and inflammation have been observed in the arterial wall of PM-exposed animals with vasomotor dysfunction or plaque progression. From the data, it is evident that pulmonary and systemic inflammation does not seem to be necessary for these vascular effects to occur. Furthermore, there is inconsistent evidence with regard to altered plasma lipid profile and systemic inflammation as a key step in vasomotor dysfunction and progression of atherosclerosis in PM-exposed animals. In summary, the results show that certain nanomaterials, including TiO2, carbon black and carbon nanotubes, have similar hazards to the vascular system as combustion-derived PM.

AB - Exposure to particulate matter (PM) from traffic vehicles is hazardous to the vascular system, leading to clinical manifestations and mortality due to ischemic heart disease. By analogy, nanomaterials may also be associated with the same outcomes. Here, the effects of exposure to PM from ambient air, diesel exhaust and certain nanomaterials on atherosclerosis and vasomotor function in animals have been assessed. The majority of studies have used pulmonary exposure by inhalation or instillation, although there are some studies on non-pulmonary routes such as the gastrointestinal tract. Airway exposure to air pollution particles and nanomaterials is associated with similar effects on atherosclerosis progression, augmented vasoconstriction and blunted vasorelaxation responses in arteries, whereas exposure to diesel exhaust is associated with lower responses. At present, there is no convincing evidence of dose-dependent effects across studies. Oxidative stress and inflammation have been observed in the arterial wall of PM-exposed animals with vasomotor dysfunction or plaque progression. From the data, it is evident that pulmonary and systemic inflammation does not seem to be necessary for these vascular effects to occur. Furthermore, there is inconsistent evidence with regard to altered plasma lipid profile and systemic inflammation as a key step in vasomotor dysfunction and progression of atherosclerosis in PM-exposed animals. In summary, the results show that certain nanomaterials, including TiO2, carbon black and carbon nanotubes, have similar hazards to the vascular system as combustion-derived PM.

KW - Air pollution

KW - atherosclerosis

KW - nanomaterials

KW - particulate matter

KW - vasomotor dysfunction

U2 - 10.3109/10408444.2016.1149451

DO - 10.3109/10408444.2016.1149451

M3 - Review

C2 - 27028752

VL - 46

SP - 437

EP - 476

JO - Critical Reviews in Toxicology

JF - Critical Reviews in Toxicology

SN - 1040-8444

IS - 5

ER -

ID: 166323101