Blood Pressure Lowering Medication, Visit-to-Visit Blood Pressure Variability, and Cognitive Function in Old Age

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Blood Pressure Lowering Medication, Visit-to-Visit Blood Pressure Variability, and Cognitive Function in Old Age. / Wijsman, Liselotte W; de Craen, Anton J M; Muller, Majon; Sabayan, Behnam; Stott, David; Ford, Ian; Trompet, Stella; Jukema, J Wouter; Westendorp, Rudi G J; Mooijaart, Simon P.

In: American Journal of Hypertension, Vol. 29, No. 3, 03.2016, p. 311-318.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Wijsman, LW, de Craen, AJM, Muller, M, Sabayan, B, Stott, D, Ford, I, Trompet, S, Jukema, JW, Westendorp, RGJ & Mooijaart, SP 2016, 'Blood Pressure Lowering Medication, Visit-to-Visit Blood Pressure Variability, and Cognitive Function in Old Age', American Journal of Hypertension, vol. 29, no. 3, pp. 311-318. https://doi.org/10.1093/ajh/hpv101

APA

Wijsman, L. W., de Craen, A. J. M., Muller, M., Sabayan, B., Stott, D., Ford, I., ... Mooijaart, S. P. (2016). Blood Pressure Lowering Medication, Visit-to-Visit Blood Pressure Variability, and Cognitive Function in Old Age. American Journal of Hypertension, 29(3), 311-318. https://doi.org/10.1093/ajh/hpv101

Vancouver

Wijsman LW, de Craen AJM, Muller M, Sabayan B, Stott D, Ford I et al. Blood Pressure Lowering Medication, Visit-to-Visit Blood Pressure Variability, and Cognitive Function in Old Age. American Journal of Hypertension. 2016 Mar;29(3):311-318. https://doi.org/10.1093/ajh/hpv101

Author

Wijsman, Liselotte W ; de Craen, Anton J M ; Muller, Majon ; Sabayan, Behnam ; Stott, David ; Ford, Ian ; Trompet, Stella ; Jukema, J Wouter ; Westendorp, Rudi G J ; Mooijaart, Simon P. / Blood Pressure Lowering Medication, Visit-to-Visit Blood Pressure Variability, and Cognitive Function in Old Age. In: American Journal of Hypertension. 2016 ; Vol. 29, No. 3. pp. 311-318.

Bibtex

@article{c9be4f65614c4e7aba3ac23f09ae32e3,
title = "Blood Pressure Lowering Medication, Visit-to-Visit Blood Pressure Variability, and Cognitive Function in Old Age",
abstract = "BACKGROUND: Visit-to-visit blood pressure (BP) variability is associated with cognitive impairment. We assessed to what extent the association between BP variability and cognitive impairment is mediated by the association of BP lowering medication (BPLM) with both BP variability and cognition.METHODS: We studied 5,606 participants from the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER). BP was measured every 3 months during 3.2 years; BP variability was defined as the SD of BP measurements during follow-up. Cognitive function was assessed at baseline and during follow-up using the Stroop test, Letter-Digit Coding test, and immediate and delayed Picture-Word Learning tests. Multivariate regression models were used with and without adjustments for BPLM to calculate the percentage to which BPLM mediated the association between BP variability and cognition.RESULTS: Participants taking calcium antagonists had a higher score in baseline Letter-Digit Coding test (mean difference (95{\%} confidence interval (CI) 0.45 (0.06; 0.88). Participants taking beta-blockers had a steeper decline in Stroop test (additional change per year (95{\%} CI) 0.40 (0.09; 0.70) and Letter-Digit Coding test (0.08 (-0.15; -0.02)). Furthermore, a steeper decline in Stroop test was found in participants taking renin-angiotensin system (RAS) inhibitors (0.50 (0.16; 0.85). Systolic BP variability was higher in participants taking beta-blockers and RAS inhibitors (mean difference in systolic BP variability in mm Hg (95{\%} CI) 0.75 (0.45; 1.04) and 1.37 (1.04; 1.71) respectively). Participants taking diuretics, calcium antagonists, and RAS inhibitors had a higher diastolic BP variability (mean difference in diastolic BP variability in mm Hg (95{\%} CI) 0.27 (0.04; 0.49), 0.37 (0.12; 0.62) and 0.65 (0.37; 0.93) SD, respectively). Beta estimates remained essentially the same when we adjusted for BPLM in the association of BP variability with cognitive function.CONCLUSIONS: The association between BP variability and cognitive impairment was not mediated by BPLM.",
author = "Wijsman, {Liselotte W} and {de Craen}, {Anton J M} and Majon Muller and Behnam Sabayan and David Stott and Ian Ford and Stella Trompet and Jukema, {J Wouter} and Westendorp, {Rudi G J} and Mooijaart, {Simon P}",
note = "{\circledC} American Journal of Hypertension, Ltd 2015. All rights reserved. For Permissions, please email: journals.permissions@oup.com.",
year = "2016",
month = "3",
doi = "10.1093/ajh/hpv101",
language = "English",
volume = "29",
pages = "311--318",
journal = "American Journal of Hypertension",
issn = "0895-7061",
publisher = "Oxford University Press",
number = "3",

}

RIS

TY - JOUR

T1 - Blood Pressure Lowering Medication, Visit-to-Visit Blood Pressure Variability, and Cognitive Function in Old Age

AU - Wijsman, Liselotte W

AU - de Craen, Anton J M

AU - Muller, Majon

AU - Sabayan, Behnam

AU - Stott, David

AU - Ford, Ian

AU - Trompet, Stella

AU - Jukema, J Wouter

AU - Westendorp, Rudi G J

AU - Mooijaart, Simon P

N1 - © American Journal of Hypertension, Ltd 2015. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

PY - 2016/3

Y1 - 2016/3

N2 - BACKGROUND: Visit-to-visit blood pressure (BP) variability is associated with cognitive impairment. We assessed to what extent the association between BP variability and cognitive impairment is mediated by the association of BP lowering medication (BPLM) with both BP variability and cognition.METHODS: We studied 5,606 participants from the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER). BP was measured every 3 months during 3.2 years; BP variability was defined as the SD of BP measurements during follow-up. Cognitive function was assessed at baseline and during follow-up using the Stroop test, Letter-Digit Coding test, and immediate and delayed Picture-Word Learning tests. Multivariate regression models were used with and without adjustments for BPLM to calculate the percentage to which BPLM mediated the association between BP variability and cognition.RESULTS: Participants taking calcium antagonists had a higher score in baseline Letter-Digit Coding test (mean difference (95% confidence interval (CI) 0.45 (0.06; 0.88). Participants taking beta-blockers had a steeper decline in Stroop test (additional change per year (95% CI) 0.40 (0.09; 0.70) and Letter-Digit Coding test (0.08 (-0.15; -0.02)). Furthermore, a steeper decline in Stroop test was found in participants taking renin-angiotensin system (RAS) inhibitors (0.50 (0.16; 0.85). Systolic BP variability was higher in participants taking beta-blockers and RAS inhibitors (mean difference in systolic BP variability in mm Hg (95% CI) 0.75 (0.45; 1.04) and 1.37 (1.04; 1.71) respectively). Participants taking diuretics, calcium antagonists, and RAS inhibitors had a higher diastolic BP variability (mean difference in diastolic BP variability in mm Hg (95% CI) 0.27 (0.04; 0.49), 0.37 (0.12; 0.62) and 0.65 (0.37; 0.93) SD, respectively). Beta estimates remained essentially the same when we adjusted for BPLM in the association of BP variability with cognitive function.CONCLUSIONS: The association between BP variability and cognitive impairment was not mediated by BPLM.

AB - BACKGROUND: Visit-to-visit blood pressure (BP) variability is associated with cognitive impairment. We assessed to what extent the association between BP variability and cognitive impairment is mediated by the association of BP lowering medication (BPLM) with both BP variability and cognition.METHODS: We studied 5,606 participants from the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER). BP was measured every 3 months during 3.2 years; BP variability was defined as the SD of BP measurements during follow-up. Cognitive function was assessed at baseline and during follow-up using the Stroop test, Letter-Digit Coding test, and immediate and delayed Picture-Word Learning tests. Multivariate regression models were used with and without adjustments for BPLM to calculate the percentage to which BPLM mediated the association between BP variability and cognition.RESULTS: Participants taking calcium antagonists had a higher score in baseline Letter-Digit Coding test (mean difference (95% confidence interval (CI) 0.45 (0.06; 0.88). Participants taking beta-blockers had a steeper decline in Stroop test (additional change per year (95% CI) 0.40 (0.09; 0.70) and Letter-Digit Coding test (0.08 (-0.15; -0.02)). Furthermore, a steeper decline in Stroop test was found in participants taking renin-angiotensin system (RAS) inhibitors (0.50 (0.16; 0.85). Systolic BP variability was higher in participants taking beta-blockers and RAS inhibitors (mean difference in systolic BP variability in mm Hg (95% CI) 0.75 (0.45; 1.04) and 1.37 (1.04; 1.71) respectively). Participants taking diuretics, calcium antagonists, and RAS inhibitors had a higher diastolic BP variability (mean difference in diastolic BP variability in mm Hg (95% CI) 0.27 (0.04; 0.49), 0.37 (0.12; 0.62) and 0.65 (0.37; 0.93) SD, respectively). Beta estimates remained essentially the same when we adjusted for BPLM in the association of BP variability with cognitive function.CONCLUSIONS: The association between BP variability and cognitive impairment was not mediated by BPLM.

U2 - 10.1093/ajh/hpv101

DO - 10.1093/ajh/hpv101

M3 - Journal article

VL - 29

SP - 311

EP - 318

JO - American Journal of Hypertension

JF - American Journal of Hypertension

SN - 0895-7061

IS - 3

ER -

ID: 141479733