Breast cancer with different prognostic characteristics developing in Danish women using hormone replacement therapy
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Breast cancer with different prognostic characteristics developing in Danish women using hormone replacement therapy. / Stahlberg, Claudia; Pedersen, A T; Andersen, Zorana Jovanovic; Keiding, N; Hundrup, Y A; Obel, E B; Møller, S; Rank, F; Ottesen, B; Lynge, E.
In: British Journal of Cancer, Vol. 91, No. 4, 16.08.2004, p. 644-650.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - Breast cancer with different prognostic characteristics developing in Danish women using hormone replacement therapy
AU - Stahlberg, Claudia
AU - Pedersen, A T
AU - Andersen, Zorana Jovanovic
AU - Keiding, N
AU - Hundrup, Y A
AU - Obel, E B
AU - Møller, S
AU - Rank, F
AU - Ottesen, B
AU - Lynge, E
PY - 2004/8/16
Y1 - 2004/8/16
N2 - The aim of this study is to investigate the risk of developing prognostic different types of breast cancer in women using hormone replacement therapy (HRT). A total of 10 874 postmenopausal Danish Nurses were followed since 1993. Incident breast cancer cases and histopathological information were retrieved through the National Danish registries. The follow-up ended on 31 December 1999. Breast cancer developed in 244 women, of whom 172 were invasive ductal carcinomas. Compared to never users, current users of HRT had an increased risk of a hormone receptor-positive breast cancer, but a neutral risk of receptor-negative breast cancer, relative risk (RR) 3.29 (95% confidence interval (CI): 2.27-4.77) and RR 0.99 (95% CI: 0.42-2.36), respectively (P for difference=0.013). The risk of being diagnosed with low histological malignancy grade was higher than high malignancy grade with RR 4.13 (95% CI: 2.43-7.01) and RR 2.17 (95% CI: 1.42-3.30), respectively (P=0.063). For breast cancers with other prognostic characteristics, the risk was increased equally for the favourable and non favourable types. Current users of HRT experience a two- to four-fold increased risk of breast cancer with various prognostic characteristics, both the favourable and non favourable types. For receptor status, the risk with HRT was statistically significantly higher for hormone receptor-positive breast cancer compared to receptor-negative breast cancer.
AB - The aim of this study is to investigate the risk of developing prognostic different types of breast cancer in women using hormone replacement therapy (HRT). A total of 10 874 postmenopausal Danish Nurses were followed since 1993. Incident breast cancer cases and histopathological information were retrieved through the National Danish registries. The follow-up ended on 31 December 1999. Breast cancer developed in 244 women, of whom 172 were invasive ductal carcinomas. Compared to never users, current users of HRT had an increased risk of a hormone receptor-positive breast cancer, but a neutral risk of receptor-negative breast cancer, relative risk (RR) 3.29 (95% confidence interval (CI): 2.27-4.77) and RR 0.99 (95% CI: 0.42-2.36), respectively (P for difference=0.013). The risk of being diagnosed with low histological malignancy grade was higher than high malignancy grade with RR 4.13 (95% CI: 2.43-7.01) and RR 2.17 (95% CI: 1.42-3.30), respectively (P=0.063). For breast cancers with other prognostic characteristics, the risk was increased equally for the favourable and non favourable types. Current users of HRT experience a two- to four-fold increased risk of breast cancer with various prognostic characteristics, both the favourable and non favourable types. For receptor status, the risk with HRT was statistically significantly higher for hormone receptor-positive breast cancer compared to receptor-negative breast cancer.
KW - Aged
KW - Breast Neoplasms
KW - Carcinoma, Ductal, Breast
KW - Cohort Studies
KW - Denmark
KW - Epidemiologic Studies
KW - Female
KW - Hormone Replacement Therapy
KW - Humans
KW - Incidence
KW - Middle Aged
KW - Postmenopause
KW - Prognosis
KW - Registries
KW - Risk Factors
KW - Survival Analysis
U2 - 10.1038/sj.bjc.6601996
DO - 10.1038/sj.bjc.6601996
M3 - Journal article
C2 - 15238982
VL - 91
SP - 644
EP - 650
JO - The British journal of cancer. Supplement
JF - The British journal of cancer. Supplement
SN - 0007-0920
IS - 4
ER -
ID: 108677