Broad-Spectrum Antibiotic Treatment and Subsequent Childhood Type 1 Diabetes: A Nationwide Danish Cohort Study

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Broad-Spectrum Antibiotic Treatment and Subsequent Childhood Type 1 Diabetes : A Nationwide Danish Cohort Study. / Clausen, Tine D; Bergholt, Thomas; Bouaziz, Olivier; Arpi, Magnus; Eriksson, Frank; Rasmussen, Steen; Keiding, Niels; Løkkegaard, Ellen C.

In: PloS one, Vol. 11, No. 8, e0161654, 25.08.2016, p. 1-15.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Clausen, TD, Bergholt, T, Bouaziz, O, Arpi, M, Eriksson, F, Rasmussen, S, Keiding, N & Løkkegaard, EC 2016, 'Broad-Spectrum Antibiotic Treatment and Subsequent Childhood Type 1 Diabetes: A Nationwide Danish Cohort Study', PloS one, vol. 11, no. 8, e0161654, pp. 1-15. https://doi.org/10.1371/journal.pone.0161654

APA

Clausen, T. D., Bergholt, T., Bouaziz, O., Arpi, M., Eriksson, F., Rasmussen, S., ... Løkkegaard, E. C. (2016). Broad-Spectrum Antibiotic Treatment and Subsequent Childhood Type 1 Diabetes: A Nationwide Danish Cohort Study. PloS one, 11(8), 1-15. [e0161654]. https://doi.org/10.1371/journal.pone.0161654

Vancouver

Clausen TD, Bergholt T, Bouaziz O, Arpi M, Eriksson F, Rasmussen S et al. Broad-Spectrum Antibiotic Treatment and Subsequent Childhood Type 1 Diabetes: A Nationwide Danish Cohort Study. PloS one. 2016 Aug 25;11(8):1-15. e0161654. https://doi.org/10.1371/journal.pone.0161654

Author

Clausen, Tine D ; Bergholt, Thomas ; Bouaziz, Olivier ; Arpi, Magnus ; Eriksson, Frank ; Rasmussen, Steen ; Keiding, Niels ; Løkkegaard, Ellen C. / Broad-Spectrum Antibiotic Treatment and Subsequent Childhood Type 1 Diabetes : A Nationwide Danish Cohort Study. In: PloS one. 2016 ; Vol. 11, No. 8. pp. 1-15.

Bibtex

@article{286355b5c5964f75b5148bc8953076e3,
title = "Broad-Spectrum Antibiotic Treatment and Subsequent Childhood Type 1 Diabetes: A Nationwide Danish Cohort Study",
abstract = "BACKGROUND: Studies link antibiotic treatment and delivery by cesarean section with increased risk of chronic diseases through changes of the gut-microbiota. We aimed to evaluate the association of broad-spectrum antibiotic treatment during the first two years of life with subsequent onset of childhood type 1 diabetes and the potential effect-modification by mode of delivery.MATERIALS AND METHODS: A Danish nationwide cohort study including all singletons born during 1997-2010. End of follow-up by December 2012. Four national registers provided information on antibiotic redemptions, outcome and confounders. Redemptions of antibiotic prescriptions during the first two years of life was classified into narrow-spectrum or broad-spectrum antibiotics. Children were followed from age two to fourteen, both inclusive. The risk of type 1 diabetes with onset before the age of 15 years was assessed by Cox regression. A total of 858,201 singletons contributed 5,906,069 person-years, during which 1,503 children developed type 1 diabetes.RESULTS: Redemption of broad-spectrum antibiotics during the first two years of life was associated with an increased rate of type 1 diabetes during the following 13 years of life (HR 1.13; 95{\%} CI 1.02 to 1.25), however, the rate was modified by mode of delivery. Broad-spectrum antibiotics were associated with an increased rate of type 1 diabetes in children delivered by either intrapartum cesarean section (HR 1.70; 95{\%} CI 1.15 to 2.51) or prelabor cesarean section (HR 1.63; 95{\%} CI 1.11 to 2.39), but not in vaginally delivered children. Number needed to harm was 433 and 562, respectively. The association with broad-spectrum antibiotics was not modified by parity, genetic predisposition or maternal redemption of antibiotics during pregnancy or lactation.CONCLUSIONS: Redemption of broad-spectrum antibiotics during infancy is associated with an increased risk of childhood type 1 diabetes in children delivered by cesarean section.",
keywords = "Journal Article",
author = "Clausen, {Tine D} and Thomas Bergholt and Olivier Bouaziz and Magnus Arpi and Frank Eriksson and Steen Rasmussen and Niels Keiding and L{\o}kkegaard, {Ellen C}",
year = "2016",
month = "8",
day = "25",
doi = "10.1371/journal.pone.0161654",
language = "English",
volume = "11",
pages = "1--15",
journal = "P L o S One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "8",

}

RIS

TY - JOUR

T1 - Broad-Spectrum Antibiotic Treatment and Subsequent Childhood Type 1 Diabetes

T2 - A Nationwide Danish Cohort Study

AU - Clausen, Tine D

AU - Bergholt, Thomas

AU - Bouaziz, Olivier

AU - Arpi, Magnus

AU - Eriksson, Frank

AU - Rasmussen, Steen

AU - Keiding, Niels

AU - Løkkegaard, Ellen C

PY - 2016/8/25

Y1 - 2016/8/25

N2 - BACKGROUND: Studies link antibiotic treatment and delivery by cesarean section with increased risk of chronic diseases through changes of the gut-microbiota. We aimed to evaluate the association of broad-spectrum antibiotic treatment during the first two years of life with subsequent onset of childhood type 1 diabetes and the potential effect-modification by mode of delivery.MATERIALS AND METHODS: A Danish nationwide cohort study including all singletons born during 1997-2010. End of follow-up by December 2012. Four national registers provided information on antibiotic redemptions, outcome and confounders. Redemptions of antibiotic prescriptions during the first two years of life was classified into narrow-spectrum or broad-spectrum antibiotics. Children were followed from age two to fourteen, both inclusive. The risk of type 1 diabetes with onset before the age of 15 years was assessed by Cox regression. A total of 858,201 singletons contributed 5,906,069 person-years, during which 1,503 children developed type 1 diabetes.RESULTS: Redemption of broad-spectrum antibiotics during the first two years of life was associated with an increased rate of type 1 diabetes during the following 13 years of life (HR 1.13; 95% CI 1.02 to 1.25), however, the rate was modified by mode of delivery. Broad-spectrum antibiotics were associated with an increased rate of type 1 diabetes in children delivered by either intrapartum cesarean section (HR 1.70; 95% CI 1.15 to 2.51) or prelabor cesarean section (HR 1.63; 95% CI 1.11 to 2.39), but not in vaginally delivered children. Number needed to harm was 433 and 562, respectively. The association with broad-spectrum antibiotics was not modified by parity, genetic predisposition or maternal redemption of antibiotics during pregnancy or lactation.CONCLUSIONS: Redemption of broad-spectrum antibiotics during infancy is associated with an increased risk of childhood type 1 diabetes in children delivered by cesarean section.

AB - BACKGROUND: Studies link antibiotic treatment and delivery by cesarean section with increased risk of chronic diseases through changes of the gut-microbiota. We aimed to evaluate the association of broad-spectrum antibiotic treatment during the first two years of life with subsequent onset of childhood type 1 diabetes and the potential effect-modification by mode of delivery.MATERIALS AND METHODS: A Danish nationwide cohort study including all singletons born during 1997-2010. End of follow-up by December 2012. Four national registers provided information on antibiotic redemptions, outcome and confounders. Redemptions of antibiotic prescriptions during the first two years of life was classified into narrow-spectrum or broad-spectrum antibiotics. Children were followed from age two to fourteen, both inclusive. The risk of type 1 diabetes with onset before the age of 15 years was assessed by Cox regression. A total of 858,201 singletons contributed 5,906,069 person-years, during which 1,503 children developed type 1 diabetes.RESULTS: Redemption of broad-spectrum antibiotics during the first two years of life was associated with an increased rate of type 1 diabetes during the following 13 years of life (HR 1.13; 95% CI 1.02 to 1.25), however, the rate was modified by mode of delivery. Broad-spectrum antibiotics were associated with an increased rate of type 1 diabetes in children delivered by either intrapartum cesarean section (HR 1.70; 95% CI 1.15 to 2.51) or prelabor cesarean section (HR 1.63; 95% CI 1.11 to 2.39), but not in vaginally delivered children. Number needed to harm was 433 and 562, respectively. The association with broad-spectrum antibiotics was not modified by parity, genetic predisposition or maternal redemption of antibiotics during pregnancy or lactation.CONCLUSIONS: Redemption of broad-spectrum antibiotics during infancy is associated with an increased risk of childhood type 1 diabetes in children delivered by cesarean section.

KW - Journal Article

U2 - 10.1371/journal.pone.0161654

DO - 10.1371/journal.pone.0161654

M3 - Journal article

VL - 11

SP - 1

EP - 15

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 8

M1 - e0161654

ER -

ID: 165752833