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  1. Published

    New insights into the GABAA receptor structure and orthosteric ligand binding: Receptor modeling guided by experimental data

    Sander, T., Frølund, Bente, Bruun, A. T., Ivanov, I., McCammon, J. A. & Balle, T., May 2011, In: Proteins: Structure, Function, and Bioinformatics. 79, 5, p. 1458-1477

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Studies of monoamine transporters: Phosphorylation of the serotonin transporter and interactions of antidepressants with the serotonin and norepinephrine transporters

    Sørensen, L., May 2011, København: Det Farmaceutiske Fakultet. 174 p.

    Research output: Book/Report › Ph.D. thesis › Research

  3. Published

    X-ray crystal structure and small-angle X-ray scattering of sheep liver sorbitol dehydrogenase

    Yennawar, H., Møller, M., Gillilan, R. & Yennawar, N., May 2011, In: Acta Crystallographica. Section D: Biological Crystallography. 67, Pt 5, p. 440-446

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Thapsigargin affinity purification of intracellular P2A-type Ca2+ ATPases

    Vandecaetsbeek, I., Christensen, Søren Brøgger, Liu, Huizhen, van Veldhoven, P. P., Waelkens, E., Eggermont, J., Raeymaekers, L., Møller, J. V., Nissen, P., Wuytack, F. & Vangheluwe, P., 1 May 2011, In: BBA General Subjects. 1813, 5, p. 1118-1127

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Design, synthesis, and pharmacological characterization of novel spirocyclic quinuclidinyl-Delta2 -isoxazoline derivatives as potent and selective agonists of alpha7 nicotinic acetylcholine receptors

    Dallanoce, C., Magrone, P., Matera, C., Frigerio, F., Grazioso, G., De Amici, M., Fucile, S., Piccari, V., Frydenvang, Karla Andrea, Pucci, L., Gotti, C., Clementi, F. & De Micheli, C., 2 May 2011, In: ChemMedChem. 6, 5, p. 889-903

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Expression and beta-glucan binding properties of Scots pine (Pinus sylvestris L.) antimicrobial protein (Sp-AMP)

    Sooriyaarachchi, S., Jaber, E., Covarrubias, A. S., Ubhayasekera, W., Asiegbu, F. O. & Mowbray, S. L., 17 May 2011, In: Plant Molecular Biology. 77, 1-2, p. 33-45

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Extraction and detection of Ionophores in the Aquatic Environment

    Bak, S. A., Hansen, M., Krogh, K. A., Björklund, E. & Halling-Sørensen, B., 17 May 2011.

    Research output: Contribution to conference › Poster › Research

  8. Published

    Epitope grafting, re-creating a conformational Bet v 1 antibody epitope on the surface of the homologous apple allergen Mal d 1

    Holm, J., Ferreras, M., Ipsen, H., Würtzen, P. A., Gajhede, Michael, Larsen, J. N., Lund, K. & Spangfort, M. D., 20 May 2011, In: Journal of Biological Chemistry. 286, 20, p. 17569-17578

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    In silico predictions of hERG channel blockers in drug discovery: from ligand-based and target-based approaches to systems chemical biology

    Taboureau, O. & Jørgensen, Flemming Steen, Jun 2011, In: Combinatorial Chemistry & High Throughput Screening. 14, 5, p. 375-387

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Deletion of the betaine-GABA transporter (BGT1; slc6a12) gene does not affect seizure thresholds of adult mice

    Lehre, A. C., Rowley, N. M., Zhou, Y., Holmseth, S., Guo, C., Holen, T., Hua, R., Laake, P., Olofsson, A. M., Poblete-Naredo, I., Rusakov, D. A., Madsen, K. K., Clausen, Rasmus Prætorius, Schousboe, Arne, White, H. S. & Danbolt, N. C., 1 Jun 2011, In: Epilepsy Research. 95, 1-2, p. 70-81

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Mechanism of Ca2+/calmodulin-dependent kinase II regulation of AMPA receptor gating

    Kristensen, Anders Skov, Jenkins, M. A., Banke, T. G., Schousboe, Arne, Makino, Y., Johnson, R. C., Huganir, R. & Traynelis, S. F., 1 Jun 2011, In: Nature Neuroscience. 14, 6, p. 727-735

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Synthesis of neurotransmitter GABA via the neuronal tricarboxylic acid cycle is elevated in rats with liver cirrhosis consistent with a high GABAergic tone in chronic hepatic encephalopathy

    Leke, R., Bak, Lasse Kristoffer, Iversen, P., Sørensen, M., Keiding, S., Vilstrup, H., Ott, P., Portela, L. V., Schousboe, Arne & Waagepetersen, Helle S., 1 Jun 2011, In: Journal of Neurochemistry. 117, 5, p. 824-32 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Bacterial membrane activity of alpha-peptide/beta-peptoid chimeras: influence of amino acid composition and chain length on the activity against different bacterial strains

    Hein-Kristensen, L., Knapp, K. M., Franzyk, Henrik & Gram, L., 22 Jun 2011, In: B M C Microbiology. 11, 1, p. 144

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Enzyme kinetic studies of histone demethylases KDM4C and KDM6A: Towards understanding selectivity of inhibitors targeting oncogenic histone demethylases

    Kristensen, J. B. L., Nielsen, A. L., Jørgensen, L., Kristensen, L. H., Helgstrand, C., Juknaite, L., Kristensen, Jesper Langgaard, Kastrup, Jette Sandholm Jensen, Clausen, Rasmus Prætorius, Olsen, L. & Gajhede, Michael, 23 Jun 2011, In: F E B S Letters. 585, 12, p. 1951-1956

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Chemical composition and biological screening of Capsella bursa-pastoris

    Grosso, C., Vinholes, J., Silva, L. R., Guedes de Pinho, P., Goncalves, R. F., Valentao, P., Jäger, A. K. & Andrade, P. B., Jul 2011, In: Revista Brasileira de Farmacognosia. 21, 4, p. 635-644

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Direct on-line monitoring of methylseleninic acid metabolism in hepatocytes using membrane inlet mass spectrometry

    Bak, S. A., Hansen, H. R., Badolo, L. & Lauritsen, F. R., Jul 2011.

    Research output: Contribution to conference › Poster › Research

  17. Published

    Selective GABA transporter inhibitors tiagabine and EF1502 exhibit mechanistic differences in their ability to modulate the ataxia and anticonvulsant action of the extrasynaptic GABA(A) receptor agonist gaboxadol

    Madsen, K. K., Ebert, B., Clausen, Rasmus Prætorius, Krogsgaard-Larsen, Povl, Schousboe, Arne & White, H. S., 1 Jul 2011, In: Journal of Pharmacology and Experimental Therapeutics. 338, 1, p. 214-219

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Temocene: the porphycene analogue of temoporfin (Foscan®)

    Garcia-Diaz, M., Sanchez-Garcia, D., Nonell, S., Soriano, J., Villanueva, A., Stockert, J. C., Canete, M., Sagrista, M. L. & Mora, M., 1 Jul 2011, In: MedChemComm. 2, 7, p. 616-619 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Molecular determinants for selective recognition of antidepressants in the human serotonin and norepinephrine transporters

    Andersen, J., Stuhr-Hansen, N., Zachariassen, L., Toubro, S., Hansen, S. M. R., Eildal, J. N. N., Bond, A. D., Bøgesø, K. P., Bang-Andersen, B., Kristensen, Anders Skov & Strømgaard, Kristian, 19 Jul 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 29, p. 12137-12142

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Synthesis of N-alkylated amino acids using fluorous-tagged hydroxylamines

    Nielsen, S. D., Smith, G. P., Begtrup, M. & Kristensen, Jesper Langgaard, 22 Jul 2011, In: Tetrahedron. 67, 29, p. 5261-5267

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    RS-predictor: a new tool for predicting sites of cytochrome P450-mediated metabolism applied to CYP 3A4

    Zaretzki, J., Bergeron, C., Rydberg, P., Huang, T., Bennett, K. P. & Breneman, C. M., 25 Jul 2011, In: Journal of Chemical Information and Modeling. 51, 7, p. 1667-1689

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Open3DALIGN: an open-source software aimed at unsupervised ligand alignment

    Tosco, P., Balle, T. & Shiri, F., 27 Jul 2011, In: Journal of Computer - Aided Molecular Design. 25, 8, p. 777-783

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Unraveling the high- and low-sensitivity agonist responses of nicotinic acetylcholine receptors

    Harpsøe, Kasper, Ahring, P. K., Christensen, J. K., Jensen, M. L., Peters, D. & Balle, T., 27 Jul 2011, In: Journal of Neuroscience. 31, 30, p. 10759-10766

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Extraction and detection of Ionophores in the Aquatic Environment

    Bak, S. A., Hansen, M., Krogh, K. A., Björklund, E. & Halling-Sørensen, B., Aug 2011.

    Research output: Contribution to conference › Conference abstract for conference › Research

  25. Published

    Monitoring Lidocaine Single-Crystal Dissolution by Ultraviolet Imaging

    Østergaard, Jesper, Ye, F., Rantanen, Jukka, Yaghmur, Anan, Larsen, Susan Weng, Larsen, C. S. & Jensen, H., Aug 2011, In: Journal of Pharmaceutical Sciences. 100, 8, p. 3405-3410

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    The tandem chain extension aldol reaction used for synthesis of ketomethylene tripeptidomimetics targeting hPEPT1

    Thorn, K., Nielsen, C. U., Jakobsen, P., Steffansen, B., Zercher, C. K. & Begtrup, M., Aug 2011, In: Bioorganic & Medicinal Chemistry Letters. 21, 15, p. 4597-4601

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Branched-chain amino acids increase arterial blood ammonia in spite of enhanced intrinsic muscle ammonia metabolism in patients with cirrhosis and healthy subjects

    Dam, G., Keiding, S., Munk, O. L., Ott, P., Buhl, M., Vilstrup, H., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Schousboe, Arne, Møller, N. & Sørensen, M., 1 Aug 2011, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 301, 2, p. G269-77

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Nicotine reverses anhedonic-like response and cognitive impairment in the rat chronic mild stress model of depression: comparison with sertraline

    Andreasen T., Jesper, Henningsen, K., Bate, S., Christiansen, S. & Wiborg, O., 1 Aug 2011, In: Journal of Psychopharmacology. 25, 8, p. 1134-41 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    ß-Hydroxybutyrate is the preferred substrate for GABA and glutamate synthesis while glucose is indispensable during depolarization in cultured GABAergic neurons

    Lund, Trine Meldgaard, Obel, L. F., Risa, Ø. & Sonnewald, U., 1 Aug 2011, In: Neurochemistry International. 59, 2, p. 309-18 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    The spared nerve injury (SNI) model of induced mechanical allodynia in mice

    Richner, M., Bjerrum, Ole Jannik, Nykjær, A. & Vaegter, C. B., 18 Aug 2011, In: Journal of Visualized Experiments. 54, p. e3092

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Acute but not delayed amphetamine treatment improves behavioral outcome in a rat embolic stroke model

    Rasmussen, Rune Skovgaard, Overgaard, K., Kristiansen, Uffe & Johansen, F. F., Sep 2011, In: Neurological Research. 33, 7, p. 774-782 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Do two different reaction mechanisms contribute to the hydroxylation of primary amines by cytochrome P450?

    Rydberg, P. & Olsen, L., Sep 2011, In: Journal of Chemical Theory and Computation. 7, 10, p. 3399-3404

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Evolution and applications of plant pathway resources and databases

    Sucaet, Y. & Deva, T., Sep 2011, In: Briefings in Bioinformatics. 12, 5, p. 530-544

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Effects of Teucrium polium spp. capitatum flavonoids on the lipid and carbohydrate metabolism in rats

    Stefkov, G., Kulevanova, S., Miova, B., Dinevska-Kjovkarovska, S., Mølgaard, Per, Jäger, A. K. & Josefsen, K., 1 Sep 2011, In: Pharmaceutical Biology. 49, 9, p. 885-892

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Inhibition of glutamine synthesis induces glutamate dehydrogenase-dependent ammonia fixation into alanine in co-cultures of astrocytes and neurons

    Dadsetan, S., Bak, Lasse Kristoffer, Sørensen, M., Keiding, S., Vilstrup, H., Ott, P., Leke, R., Schousboe, Arne & Waagepetersen, Helle S., 1 Sep 2011, In: Neurochemistry International. 59, 4, p. 482-8 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Ubiquitous plant compounds disturb cell-based assays

    Saaby, Lasse & Jäger, A. K., 1 Sep 2011, In: Journal of Ethnopharmacology. 137, 1, p. 942-943

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  37. Published

    Targeting histone lysine demethylases by truncating the histone 3 tail to obtain selective substrate-based inhibitors

    Lohse, B., Nielsen, A. L., Kristensen, J. B. L., Helgstrand, C., Cloos, P. A. C., Olsen, L., Gajhede, Michael, Clausen, Rasmus Prætorius & Kristensen, Jesper Langgaard, 19 Sep 2011, In: Angewandte Chemie International Edition. 50, 39, p. 9100-9103

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    A highly selective agonist for the metabotropic glutamate receptor mGluR2

    Nielsen, S. D., Fulco, M., Serpi, M., Nielsen, Birgitte, Hansen, M. B., Hansen, K. L., Thomsen, C., Brodbeck, R., Bräuner, Hans, Pellicciari, R., Norrby, P., Greenwood, J. R. & Clausen, Rasmus Prætorius, 23 Sep 2011, In: MedChemComm. 2, 11, p. 1120-1124

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Production of unusual dispiro metabolites in Pestalotiopsis virgatula endophyte cultures: HPLC-SPE-NMR, electronic circular dichroism, and time-dependent density-functional computation study

    Kesting, J. R., Olsen, L., Stærk, Dan, Tejesvi, M. V., Kini, K. R., Prakash, H. S. & Jaroszewski, J. W., 26 Sep 2011, In: Journal of Natural Products. 74, 10, p. 2206-2215

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Metabolic profiling based on two-dimensional J-resolved 1H NMR data and parallel factor analysis

    Yilmaz, A., Nyberg, N. T. & Jaroszewski, J. W., 27 Sep 2011, In: Analytical Chemistry. 83, 21, p. 8278-8285

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Oleic and linoleic acids are active principles in Nigella sativa and stabilize an E2P conformation of the Na,K-ATPase. Fatty acids differentially regulate cardiac glycoside interaction with the pump

    Mahmmoud, Y. A. & Christensen, Søren Brøgger, Oct 2011, In: BBA General Subjects. 1808, 10, p. 2413-2420

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    The calcium-sensing receptor and calcimimetics in blood pressure modulation

    Smajilovic, S., Yano, S., Jabbari, R. & Tfelt-Hansen, J., Oct 2011, In: British Journal of Pharmacology. 164, 3, p. 884-893

    Research output: Contribution to journal › Review › Research › peer-review

  43. Published

    Antifungal metabolites from fungal endophytes of Pinus strobus

    Sumarah, M. W., Kesting, J. R., Sørensen, D. & Miller, J. D., 1 Oct 2011, In: Phytochemistry. 72, 14-15, p. 1833-1837

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Stress and medicine use for headache: does sense of coherence modify the association?

    Koushede, Vibeke Jenny, Holstein, B. E., Andersen, A. & Hansen, E. H., 1 Oct 2011, In: European Journal of Public Health. 21, 5, p. 656-61 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    A new phenylalanine derivative acts as an antagonist at the AMPA receptor GluA2 and introduces partial domain closure: Synthesis, resolution, pharmacology, and crystal structure

    Szymanska, E., Frydenvang, Karla Andrea, Contreras-Sanz, A., Pickering, Darryl S, Frola, E., Serafimoska, Z., Nielsen, Birgitte, Kastrup, Jette Sandholm Jensen & Johansen, Tommy Nørskov, 4 Oct 2011, In: Journal of Medicinal Chemistry. 54, 20, p. 7289-7298

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Antimicrobial evaluation of Huilliche plant medicine used to treat wounds

    Mølgaard, Per, Holler, J. G., Asar, B., Liberna, I., Rosenbæk, L. B., Jebjerg, C. P., Jørgensen, L., Lauritzen, J., Guzman, A., Adsersen, A. & Simonsen, H. T., 31 Oct 2011, In: Journal of Ethnopharmacology. 138, 1, p. 219-227

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Alleviation of nociception in rats by treatment with ceftriaxone, a ß-lactam that promote the expression of the excitatory amino acid transporter 2

    Bjerrum, Ole Jannik, Abrahamsen, B. & Honoré, P. G. H., Nov 2011.

    Research output: Contribution to conference › Poster › Communication

  48. Published

    Pharmacological and physiological studies of the calcium-sensing receptor

    Thomsen, A. R. B., Nov 2011, København: Det Farmaceutiske Fakultet. 89 p.

    Research output: Book/Report › Ph.D. thesis › Research

  49. Published

    SDF2XYZ2SDF: how to exploit TINKER power in cheminformatics projects

    Tosco, P., Balle, T. & Shiri, F., Nov 2011, In: Journal of Molecular Modeling. 17, 11, p. 3021-3023

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Modest effect on plaque progression and vasodilatory function in atherosclerosis-prone mice exposed to nanosized TiO2

    Mikkelsen, L., Sheykhzade, Majid, Jensen, K. A., Saber, A. T., Jacobsen, N. R., Vogel, U. B., Wallin, H., Loft, Steffen & Møller, Peter, 10 Nov 2011, In: Particle and Fibre Toxicology. 8, 1, p. 32

    Research output: Contribution to journal › Journal article › Research › peer-review

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