Cause-Specific Stillbirth and Neonatal Death According to Prepregnancy Obesity and Early Gestational Weight Gain: A Study in the Danish National Birth Cohort

Research output: Contribution to journal › Journal article › Research › peer-review

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Cause-Specific Stillbirth and Neonatal Death According to Prepregnancy Obesity and Early Gestational Weight Gain : A Study in the Danish National Birth Cohort. / Nohr, Ellen Aagaard; Wolff, Sanne; Kirkegaard, Helene; Wu, Chunsen; Andersen, Anne-Marie Nybo; Olsen, Jorn; Bech, Bodil Hammer.

In: Nutrients, Vol. 13, No. 5, 1676, 2021.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nohr, EA, Wolff, S, Kirkegaard, H, Wu, C, Andersen, A-MN, Olsen, J & Bech, BH 2021, 'Cause-Specific Stillbirth and Neonatal Death According to Prepregnancy Obesity and Early Gestational Weight Gain: A Study in the Danish National Birth Cohort', Nutrients, vol. 13, no. 5, 1676. https://doi.org/10.3390/nu13051676

APA

Nohr, E. A., Wolff, S., Kirkegaard, H., Wu, C., Andersen, A-M. N., Olsen, J., & Bech, B. H. (2021). Cause-Specific Stillbirth and Neonatal Death According to Prepregnancy Obesity and Early Gestational Weight Gain: A Study in the Danish National Birth Cohort. Nutrients, 13(5), [1676]. https://doi.org/10.3390/nu13051676

Vancouver

Nohr EA, Wolff S, Kirkegaard H, Wu C, Andersen A-MN, Olsen J et al. Cause-Specific Stillbirth and Neonatal Death According to Prepregnancy Obesity and Early Gestational Weight Gain: A Study in the Danish National Birth Cohort. Nutrients. 2021;13(5). 1676. https://doi.org/10.3390/nu13051676

Author

Nohr, Ellen Aagaard ; Wolff, Sanne ; Kirkegaard, Helene ; Wu, Chunsen ; Andersen, Anne-Marie Nybo ; Olsen, Jorn ; Bech, Bodil Hammer. / Cause-Specific Stillbirth and Neonatal Death According to Prepregnancy Obesity and Early Gestational Weight Gain : A Study in the Danish National Birth Cohort. In: Nutrients. 2021 ; Vol. 13, No. 5.

Bibtex

@article{b508d89188e8408299762a9a5cf7f6ff,
title = "Cause-Specific Stillbirth and Neonatal Death According to Prepregnancy Obesity and Early Gestational Weight Gain: A Study in the Danish National Birth Cohort",
abstract = "Maternal obesity is associated with impaired fetal and neonatal survival, but underlying mechanisms are poorly understood. We examined how prepregnancy BMI and early gestational weight gain (GWG) were associated with cause-specific stillbirth and neonatal death. In 85,822 pregnancies in the Danish National Birth Cohort (1996-2002), we identified causes of death from medical records for 272 late stillbirths and 228 neonatal deaths. Prepregnancy BMI and early GWG derived from an early pregnancy interview and Cox regression were used to estimate associations with stillbirth or neonatal death as a combined outcome and nine specific cause-of-death categories. Compared to women with normal weight, risk of stillbirth or neonatal death was increased by 66% with overweight and 78% with obesity. Especially deaths due to placental dysfunction, umbilical cord complications, intrapartum events, and infections were increased in women with obesity. More stillbirths and neonatal deaths were observed in women with BMI < 25 and low GWG. Additionally, unexplained intrauterine death was increased with low GWG, while more early stillbirths were seen with both low and high GWG. In conclusion, causes of death that relate to vascular and metabolic disturbances were increased in women with obesity. Low early GWG in women of normal weight deserves more clinical attention.",
keywords = "fetal death, stillbirth, neonatal death, pregnancy, obesity, body mass index, gestational weight gain, gestational weight loss, BODY-MASS INDEX, CLASSIFYING PERINATAL DEATH, HIGH-FAT DIET, MATERNAL OBESITY, INFANT-DEATH, FETAL-DEATH, EARLY-PREGNANCY, POSTTERM BIRTH, RISK, ASSOCIATION",
author = "Nohr, {Ellen Aagaard} and Sanne Wolff and Helene Kirkegaard and Chunsen Wu and Andersen, {Anne-Marie Nybo} and Jorn Olsen and Bech, {Bodil Hammer}",
year = "2021",
doi = "10.3390/nu13051676",
language = "English",
volume = "13",
journal = "Nutrients",
issn = "2072-6643",
publisher = "M D P I AG",
number = "5",

}

RIS

TY - JOUR

T1 - Cause-Specific Stillbirth and Neonatal Death According to Prepregnancy Obesity and Early Gestational Weight Gain

T2 - A Study in the Danish National Birth Cohort

AU - Nohr, Ellen Aagaard

AU - Wolff, Sanne

AU - Kirkegaard, Helene

AU - Wu, Chunsen

AU - Andersen, Anne-Marie Nybo

AU - Olsen, Jorn

AU - Bech, Bodil Hammer

PY - 2021

Y1 - 2021

N2 - Maternal obesity is associated with impaired fetal and neonatal survival, but underlying mechanisms are poorly understood. We examined how prepregnancy BMI and early gestational weight gain (GWG) were associated with cause-specific stillbirth and neonatal death. In 85,822 pregnancies in the Danish National Birth Cohort (1996-2002), we identified causes of death from medical records for 272 late stillbirths and 228 neonatal deaths. Prepregnancy BMI and early GWG derived from an early pregnancy interview and Cox regression were used to estimate associations with stillbirth or neonatal death as a combined outcome and nine specific cause-of-death categories. Compared to women with normal weight, risk of stillbirth or neonatal death was increased by 66% with overweight and 78% with obesity. Especially deaths due to placental dysfunction, umbilical cord complications, intrapartum events, and infections were increased in women with obesity. More stillbirths and neonatal deaths were observed in women with BMI < 25 and low GWG. Additionally, unexplained intrauterine death was increased with low GWG, while more early stillbirths were seen with both low and high GWG. In conclusion, causes of death that relate to vascular and metabolic disturbances were increased in women with obesity. Low early GWG in women of normal weight deserves more clinical attention.

AB - Maternal obesity is associated with impaired fetal and neonatal survival, but underlying mechanisms are poorly understood. We examined how prepregnancy BMI and early gestational weight gain (GWG) were associated with cause-specific stillbirth and neonatal death. In 85,822 pregnancies in the Danish National Birth Cohort (1996-2002), we identified causes of death from medical records for 272 late stillbirths and 228 neonatal deaths. Prepregnancy BMI and early GWG derived from an early pregnancy interview and Cox regression were used to estimate associations with stillbirth or neonatal death as a combined outcome and nine specific cause-of-death categories. Compared to women with normal weight, risk of stillbirth or neonatal death was increased by 66% with overweight and 78% with obesity. Especially deaths due to placental dysfunction, umbilical cord complications, intrapartum events, and infections were increased in women with obesity. More stillbirths and neonatal deaths were observed in women with BMI < 25 and low GWG. Additionally, unexplained intrauterine death was increased with low GWG, while more early stillbirths were seen with both low and high GWG. In conclusion, causes of death that relate to vascular and metabolic disturbances were increased in women with obesity. Low early GWG in women of normal weight deserves more clinical attention.

KW - fetal death

KW - stillbirth

KW - neonatal death

KW - pregnancy

KW - obesity

KW - body mass index

KW - gestational weight gain

KW - gestational weight loss

KW - BODY-MASS INDEX

KW - CLASSIFYING PERINATAL DEATH

KW - HIGH-FAT DIET

KW - MATERNAL OBESITY

KW - INFANT-DEATH

KW - FETAL-DEATH

KW - EARLY-PREGNANCY

KW - POSTTERM BIRTH

KW - RISK

KW - ASSOCIATION

U2 - 10.3390/nu13051676

DO - 10.3390/nu13051676

M3 - Journal article

C2 - 34063336

VL - 13

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 5

M1 - 1676

ER -

ID: 273124879