Changes in parental smoking during pregnancy and risks of adverse birth outcomes and childhood overweight in Europe and North America: An individual participant data meta-analysis of 229,000 singleton births

Research output: Contribution to journalJournal articlepeer-review

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Changes in parental smoking during pregnancy and risks of adverse birth outcomes and childhood overweight in Europe and North America : An individual participant data meta-analysis of 229,000 singleton births. / Philips, Elise M.; Santos, Susana; Trasande, Leonardo; Aurrekoetxea, Juan J.; Barros, Henrique; von Berg, Andrea; Bergström, Anna; Bird, Philippa K.; Brescianini, Sonia; Chaoimh, Carol Ni; Charles, Marie-Aline; Chatzi, Leda; Chevrier, Cécile; Chrousos, George P.; Costet, Nathalie; Criswell, Rachel; Crozier, Sarah; Eggesbo, Merete; Fantini, Maria Pia; Farchi, Sara; Forastiere, Francesco; van Gelder, Marleen M. H. J.; Georgiu, Vagelis; Godfrey, Keith M.; Gori, Davide; Hanke, Wojciech; Heude, Barbara; Hryhorczuk, Daniel; Iñiguez, Carmen; Inskip, Hazel; Karvonen, Anne M.; Kenny, Louise C.; Kull, Inger; Lawlor, Debbie A.; Lehmann, Irina; Magnus, Per; Manios, Yannis; Melén, Erik; Mommers, Monique; Morgen, Camilla S.; Moschonis, George; Murray, Deirdre; Nohr, Ellen A.; Nybo Andersen, Anne-Marie; Oken, Emily; Oostvogels, Adriëtte J. J. M.; Papadopoulou, Eleni; Pekkanen, Juha; Pizzi, Costanza; Polanska, Kinga; Porta, Daniela; Richiardi, Lorenzo; Rifas-Shiman, Sheryl L.; Roeleveld, Nel; Rusconi, Franca; Santos, Ana C.; Sørensen, Thorkild I.A.; Standl, Marie; Stoltenberg, Camilla; Sunyer, Jordi; Thiering, Elisabeth; Thijs, Carel; Torrent, Maties; Vrijkotte, Tanja G. M.; Wright, John; Zvinchuk, Oleksandr; Gaillard, Romy; Jaddoe, Vincent W. V.

In: PLoS Medicine, Vol. 17, No. 8, e1003182, 2020.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Philips, EM, Santos, S, Trasande, L, Aurrekoetxea, JJ, Barros, H, von Berg, A, Bergström, A, Bird, PK, Brescianini, S, Chaoimh, CN, Charles, M-A, Chatzi, L, Chevrier, C, Chrousos, GP, Costet, N, Criswell, R, Crozier, S, Eggesbo, M, Fantini, MP, Farchi, S, Forastiere, F, van Gelder, MMHJ, Georgiu, V, Godfrey, KM, Gori, D, Hanke, W, Heude, B, Hryhorczuk, D, Iñiguez, C, Inskip, H, Karvonen, AM, Kenny, LC, Kull, I, Lawlor, DA, Lehmann, I, Magnus, P, Manios, Y, Melén, E, Mommers, M, Morgen, CS, Moschonis, G, Murray, D, Nohr, EA, Nybo Andersen, A-M, Oken, E, Oostvogels, AJJM, Papadopoulou, E, Pekkanen, J, Pizzi, C, Polanska, K, Porta, D, Richiardi, L, Rifas-Shiman, SL, Roeleveld, N, Rusconi, F, Santos, AC, Sørensen, TIA, Standl, M, Stoltenberg, C, Sunyer, J, Thiering, E, Thijs, C, Torrent, M, Vrijkotte, TGM, Wright, J, Zvinchuk, O, Gaillard, R & Jaddoe, VWV 2020, 'Changes in parental smoking during pregnancy and risks of adverse birth outcomes and childhood overweight in Europe and North America: An individual participant data meta-analysis of 229,000 singleton births', PLoS Medicine, vol. 17, no. 8, e1003182. https://doi.org/10.1371/journal.pmed.1003182

APA

Philips, E. M., Santos, S., Trasande, L., Aurrekoetxea, J. J., Barros, H., von Berg, A., Bergström, A., Bird, P. K., Brescianini, S., Chaoimh, C. N., Charles, M-A., Chatzi, L., Chevrier, C., Chrousos, G. P., Costet, N., Criswell, R., Crozier, S., Eggesbo, M., Fantini, M. P., ... Jaddoe, V. W. V. (2020). Changes in parental smoking during pregnancy and risks of adverse birth outcomes and childhood overweight in Europe and North America: An individual participant data meta-analysis of 229,000 singleton births. PLoS Medicine, 17(8), [e1003182]. https://doi.org/10.1371/journal.pmed.1003182

Vancouver

Philips EM, Santos S, Trasande L, Aurrekoetxea JJ, Barros H, von Berg A et al. Changes in parental smoking during pregnancy and risks of adverse birth outcomes and childhood overweight in Europe and North America: An individual participant data meta-analysis of 229,000 singleton births. PLoS Medicine. 2020;17(8). e1003182. https://doi.org/10.1371/journal.pmed.1003182

Author

Philips, Elise M. ; Santos, Susana ; Trasande, Leonardo ; Aurrekoetxea, Juan J. ; Barros, Henrique ; von Berg, Andrea ; Bergström, Anna ; Bird, Philippa K. ; Brescianini, Sonia ; Chaoimh, Carol Ni ; Charles, Marie-Aline ; Chatzi, Leda ; Chevrier, Cécile ; Chrousos, George P. ; Costet, Nathalie ; Criswell, Rachel ; Crozier, Sarah ; Eggesbo, Merete ; Fantini, Maria Pia ; Farchi, Sara ; Forastiere, Francesco ; van Gelder, Marleen M. H. J. ; Georgiu, Vagelis ; Godfrey, Keith M. ; Gori, Davide ; Hanke, Wojciech ; Heude, Barbara ; Hryhorczuk, Daniel ; Iñiguez, Carmen ; Inskip, Hazel ; Karvonen, Anne M. ; Kenny, Louise C. ; Kull, Inger ; Lawlor, Debbie A. ; Lehmann, Irina ; Magnus, Per ; Manios, Yannis ; Melén, Erik ; Mommers, Monique ; Morgen, Camilla S. ; Moschonis, George ; Murray, Deirdre ; Nohr, Ellen A. ; Nybo Andersen, Anne-Marie ; Oken, Emily ; Oostvogels, Adriëtte J. J. M. ; Papadopoulou, Eleni ; Pekkanen, Juha ; Pizzi, Costanza ; Polanska, Kinga ; Porta, Daniela ; Richiardi, Lorenzo ; Rifas-Shiman, Sheryl L. ; Roeleveld, Nel ; Rusconi, Franca ; Santos, Ana C. ; Sørensen, Thorkild I.A. ; Standl, Marie ; Stoltenberg, Camilla ; Sunyer, Jordi ; Thiering, Elisabeth ; Thijs, Carel ; Torrent, Maties ; Vrijkotte, Tanja G. M. ; Wright, John ; Zvinchuk, Oleksandr ; Gaillard, Romy ; Jaddoe, Vincent W. V. / Changes in parental smoking during pregnancy and risks of adverse birth outcomes and childhood overweight in Europe and North America : An individual participant data meta-analysis of 229,000 singleton births. In: PLoS Medicine. 2020 ; Vol. 17, No. 8.

Bibtex

@article{d063aee75e114aecb2c11b8f1a49395a,
title = "Changes in parental smoking during pregnancy and risks of adverse birth outcomes and childhood overweight in Europe and North America: An individual participant data meta-analysis of 229,000 singleton births",
abstract = "Author summaryWhy was this study done? Maternal smoking during pregnancy is an important risk factor for various birth complications and childhood overweight. It is not clear whether this increased risk is also present if mothers smoke during the first trimester only or reduce the number of cigarettes during pregnancy. The associations of paternal smoking with birth and childhood outcomes also remain unknown. What did the researchers do and find? We conducted an individual participant data meta-analysis using data from 229,158 families from 28 pregnancy and birth cohorts from Europe and North America to assess the associations of parental smoking during pregnancy, specifically of quitting or reducing smoking and maternal and paternal smoking combined, with preterm birth, small size for gestational age, and childhood overweight. We observed that smoking in the first trimester only did not increase the risk of preterm birth and small size for gestational age but was associated with a higher risk of childhood overweight, as compared to nonsmoking. Reducing the number of cigarettes during pregnancy, without quitting, was still associated with higher risks of these adverse outcomes. Paternal smoking seems to be associated, independently of maternal smoking, with the risks of childhood overweight. What do these findings mean? Population strategies should focus on parental smoking prevention before or at the start of, rather than during, pregnancy. Future studies are needed to assess the specific associations of smoking in the preconception and childhood periods with offspring outcomes.Background Fetal smoke exposure is a common and key avoidable risk factor for birth complications and seems to influence later risk of overweight. It is unclear whether this increased risk is also present if mothers smoke during the first trimester only or reduce the number of cigarettes during pregnancy, or when only fathers smoke. We aimed to assess the associations of parental smoking during pregnancy, specifically of quitting or reducing smoking and maternal and paternal smoking combined, with preterm birth, small size for gestational age, and childhood overweight. Methods and findings We performed an individual participant data meta-analysis among 229,158 families from 28 pregnancy/birth cohorts from Europe and North America. All 28 cohorts had information on maternal smoking, and 16 also had information on paternal smoking. In total, 22 cohorts were population-based, with birth years ranging from 1991 to 2015. The mothers' median age was 30.0 years, and most mothers were medium or highly educated. We used multilevel binary logistic regression models adjusted for maternal and paternal sociodemographic and lifestyle-related characteristics. Compared with nonsmoking mothers, maternal first trimester smoking only was not associated with adverse birth outcomes but was associated with a higher risk of childhood overweight (odds ratio [OR] 1.17 [95% CI 1.02-1.35],Pvalue = 0.030). Children from mothers who continued smoking during pregnancy had higher risks of preterm birth (OR 1.08 [95% CI 1.02-1.15],Pvalue = 0.012), small size for gestational age (OR 2.15 [95% CI 2.07-2.23],Pvalue <0.001), and childhood overweight (OR 1.42 [95% CI 1.35-1.48],Pvalue <0.001). Mothers who reduced the number of cigarettes between the first and third trimester, without quitting, still had a higher risk of small size for gestational age. However, the corresponding risk estimates were smaller than for women who continued the same amount of cigarettes throughout pregnancy (OR 1.89 [95% CI 1.52-2.34] instead of OR 2.20 [95% CI 2.02-2.42] when reducing from 5-9 to = 10 to 5-9 and",
keywords = "MATERNAL SMOKING, PRETERM BIRTH, DNA METHYLATION, ASSOCIATION, WEIGHT, GROWTH, EXPOSURE, CHILDREN, CESSATION, OBESITY",
author = "Philips, {Elise M.} and Susana Santos and Leonardo Trasande and Aurrekoetxea, {Juan J.} and Henrique Barros and {von Berg}, Andrea and Anna Bergstr{\"o}m and Bird, {Philippa K.} and Sonia Brescianini and Chaoimh, {Carol Ni} and Marie-Aline Charles and Leda Chatzi and C{\'e}cile Chevrier and Chrousos, {George P.} and Nathalie Costet and Rachel Criswell and Sarah Crozier and Merete Eggesbo and Fantini, {Maria Pia} and Sara Farchi and Francesco Forastiere and {van Gelder}, {Marleen M. H. J.} and Vagelis Georgiu and Godfrey, {Keith M.} and Davide Gori and Wojciech Hanke and Barbara Heude and Daniel Hryhorczuk and Carmen I{\~n}iguez and Hazel Inskip and Karvonen, {Anne M.} and Kenny, {Louise C.} and Inger Kull and Lawlor, {Debbie A.} and Irina Lehmann and Per Magnus and Yannis Manios and Erik Mel{\'e}n and Monique Mommers and Morgen, {Camilla S.} and George Moschonis and Deirdre Murray and Nohr, {Ellen A.} and {Nybo Andersen}, Anne-Marie and Emily Oken and Oostvogels, {Adri{\"e}tte J. J. M.} and Eleni Papadopoulou and Juha Pekkanen and Costanza Pizzi and Kinga Polanska and Daniela Porta and Lorenzo Richiardi and Rifas-Shiman, {Sheryl L.} and Nel Roeleveld and Franca Rusconi and Santos, {Ana C.} and S{\o}rensen, {Thorkild I.A.} and Marie Standl and Camilla Stoltenberg and Jordi Sunyer and Elisabeth Thiering and Carel Thijs and Maties Torrent and Vrijkotte, {Tanja G. M.} and John Wright and Oleksandr Zvinchuk and Romy Gaillard and Jaddoe, {Vincent W. V.}",
year = "2020",
doi = "10.1371/journal.pmed.1003182",
language = "English",
volume = "17",
journal = "P L o S Medicine (Online)",
issn = "1549-1277",
publisher = "Public Library of Science",
number = "8",

}

RIS

TY - JOUR

T1 - Changes in parental smoking during pregnancy and risks of adverse birth outcomes and childhood overweight in Europe and North America

T2 - An individual participant data meta-analysis of 229,000 singleton births

AU - Philips, Elise M.

AU - Santos, Susana

AU - Trasande, Leonardo

AU - Aurrekoetxea, Juan J.

AU - Barros, Henrique

AU - von Berg, Andrea

AU - Bergström, Anna

AU - Bird, Philippa K.

AU - Brescianini, Sonia

AU - Chaoimh, Carol Ni

AU - Charles, Marie-Aline

AU - Chatzi, Leda

AU - Chevrier, Cécile

AU - Chrousos, George P.

AU - Costet, Nathalie

AU - Criswell, Rachel

AU - Crozier, Sarah

AU - Eggesbo, Merete

AU - Fantini, Maria Pia

AU - Farchi, Sara

AU - Forastiere, Francesco

AU - van Gelder, Marleen M. H. J.

AU - Georgiu, Vagelis

AU - Godfrey, Keith M.

AU - Gori, Davide

AU - Hanke, Wojciech

AU - Heude, Barbara

AU - Hryhorczuk, Daniel

AU - Iñiguez, Carmen

AU - Inskip, Hazel

AU - Karvonen, Anne M.

AU - Kenny, Louise C.

AU - Kull, Inger

AU - Lawlor, Debbie A.

AU - Lehmann, Irina

AU - Magnus, Per

AU - Manios, Yannis

AU - Melén, Erik

AU - Mommers, Monique

AU - Morgen, Camilla S.

AU - Moschonis, George

AU - Murray, Deirdre

AU - Nohr, Ellen A.

AU - Nybo Andersen, Anne-Marie

AU - Oken, Emily

AU - Oostvogels, Adriëtte J. J. M.

AU - Papadopoulou, Eleni

AU - Pekkanen, Juha

AU - Pizzi, Costanza

AU - Polanska, Kinga

AU - Porta, Daniela

AU - Richiardi, Lorenzo

AU - Rifas-Shiman, Sheryl L.

AU - Roeleveld, Nel

AU - Rusconi, Franca

AU - Santos, Ana C.

AU - Sørensen, Thorkild I.A.

AU - Standl, Marie

AU - Stoltenberg, Camilla

AU - Sunyer, Jordi

AU - Thiering, Elisabeth

AU - Thijs, Carel

AU - Torrent, Maties

AU - Vrijkotte, Tanja G. M.

AU - Wright, John

AU - Zvinchuk, Oleksandr

AU - Gaillard, Romy

AU - Jaddoe, Vincent W. V.

PY - 2020

Y1 - 2020

N2 - Author summaryWhy was this study done? Maternal smoking during pregnancy is an important risk factor for various birth complications and childhood overweight. It is not clear whether this increased risk is also present if mothers smoke during the first trimester only or reduce the number of cigarettes during pregnancy. The associations of paternal smoking with birth and childhood outcomes also remain unknown. What did the researchers do and find? We conducted an individual participant data meta-analysis using data from 229,158 families from 28 pregnancy and birth cohorts from Europe and North America to assess the associations of parental smoking during pregnancy, specifically of quitting or reducing smoking and maternal and paternal smoking combined, with preterm birth, small size for gestational age, and childhood overweight. We observed that smoking in the first trimester only did not increase the risk of preterm birth and small size for gestational age but was associated with a higher risk of childhood overweight, as compared to nonsmoking. Reducing the number of cigarettes during pregnancy, without quitting, was still associated with higher risks of these adverse outcomes. Paternal smoking seems to be associated, independently of maternal smoking, with the risks of childhood overweight. What do these findings mean? Population strategies should focus on parental smoking prevention before or at the start of, rather than during, pregnancy. Future studies are needed to assess the specific associations of smoking in the preconception and childhood periods with offspring outcomes.Background Fetal smoke exposure is a common and key avoidable risk factor for birth complications and seems to influence later risk of overweight. It is unclear whether this increased risk is also present if mothers smoke during the first trimester only or reduce the number of cigarettes during pregnancy, or when only fathers smoke. We aimed to assess the associations of parental smoking during pregnancy, specifically of quitting or reducing smoking and maternal and paternal smoking combined, with preterm birth, small size for gestational age, and childhood overweight. Methods and findings We performed an individual participant data meta-analysis among 229,158 families from 28 pregnancy/birth cohorts from Europe and North America. All 28 cohorts had information on maternal smoking, and 16 also had information on paternal smoking. In total, 22 cohorts were population-based, with birth years ranging from 1991 to 2015. The mothers' median age was 30.0 years, and most mothers were medium or highly educated. We used multilevel binary logistic regression models adjusted for maternal and paternal sociodemographic and lifestyle-related characteristics. Compared with nonsmoking mothers, maternal first trimester smoking only was not associated with adverse birth outcomes but was associated with a higher risk of childhood overweight (odds ratio [OR] 1.17 [95% CI 1.02-1.35],Pvalue = 0.030). Children from mothers who continued smoking during pregnancy had higher risks of preterm birth (OR 1.08 [95% CI 1.02-1.15],Pvalue = 0.012), small size for gestational age (OR 2.15 [95% CI 2.07-2.23],Pvalue <0.001), and childhood overweight (OR 1.42 [95% CI 1.35-1.48],Pvalue <0.001). Mothers who reduced the number of cigarettes between the first and third trimester, without quitting, still had a higher risk of small size for gestational age. However, the corresponding risk estimates were smaller than for women who continued the same amount of cigarettes throughout pregnancy (OR 1.89 [95% CI 1.52-2.34] instead of OR 2.20 [95% CI 2.02-2.42] when reducing from 5-9 to = 10 to 5-9 and

AB - Author summaryWhy was this study done? Maternal smoking during pregnancy is an important risk factor for various birth complications and childhood overweight. It is not clear whether this increased risk is also present if mothers smoke during the first trimester only or reduce the number of cigarettes during pregnancy. The associations of paternal smoking with birth and childhood outcomes also remain unknown. What did the researchers do and find? We conducted an individual participant data meta-analysis using data from 229,158 families from 28 pregnancy and birth cohorts from Europe and North America to assess the associations of parental smoking during pregnancy, specifically of quitting or reducing smoking and maternal and paternal smoking combined, with preterm birth, small size for gestational age, and childhood overweight. We observed that smoking in the first trimester only did not increase the risk of preterm birth and small size for gestational age but was associated with a higher risk of childhood overweight, as compared to nonsmoking. Reducing the number of cigarettes during pregnancy, without quitting, was still associated with higher risks of these adverse outcomes. Paternal smoking seems to be associated, independently of maternal smoking, with the risks of childhood overweight. What do these findings mean? Population strategies should focus on parental smoking prevention before or at the start of, rather than during, pregnancy. Future studies are needed to assess the specific associations of smoking in the preconception and childhood periods with offspring outcomes.Background Fetal smoke exposure is a common and key avoidable risk factor for birth complications and seems to influence later risk of overweight. It is unclear whether this increased risk is also present if mothers smoke during the first trimester only or reduce the number of cigarettes during pregnancy, or when only fathers smoke. We aimed to assess the associations of parental smoking during pregnancy, specifically of quitting or reducing smoking and maternal and paternal smoking combined, with preterm birth, small size for gestational age, and childhood overweight. Methods and findings We performed an individual participant data meta-analysis among 229,158 families from 28 pregnancy/birth cohorts from Europe and North America. All 28 cohorts had information on maternal smoking, and 16 also had information on paternal smoking. In total, 22 cohorts were population-based, with birth years ranging from 1991 to 2015. The mothers' median age was 30.0 years, and most mothers were medium or highly educated. We used multilevel binary logistic regression models adjusted for maternal and paternal sociodemographic and lifestyle-related characteristics. Compared with nonsmoking mothers, maternal first trimester smoking only was not associated with adverse birth outcomes but was associated with a higher risk of childhood overweight (odds ratio [OR] 1.17 [95% CI 1.02-1.35],Pvalue = 0.030). Children from mothers who continued smoking during pregnancy had higher risks of preterm birth (OR 1.08 [95% CI 1.02-1.15],Pvalue = 0.012), small size for gestational age (OR 2.15 [95% CI 2.07-2.23],Pvalue <0.001), and childhood overweight (OR 1.42 [95% CI 1.35-1.48],Pvalue <0.001). Mothers who reduced the number of cigarettes between the first and third trimester, without quitting, still had a higher risk of small size for gestational age. However, the corresponding risk estimates were smaller than for women who continued the same amount of cigarettes throughout pregnancy (OR 1.89 [95% CI 1.52-2.34] instead of OR 2.20 [95% CI 2.02-2.42] when reducing from 5-9 to = 10 to 5-9 and

KW - MATERNAL SMOKING

KW - PRETERM BIRTH

KW - DNA METHYLATION

KW - ASSOCIATION

KW - WEIGHT

KW - GROWTH

KW - EXPOSURE

KW - CHILDREN

KW - CESSATION

KW - OBESITY

U2 - 10.1371/journal.pmed.1003182

DO - 10.1371/journal.pmed.1003182

M3 - Journal article

C2 - 32810184

VL - 17

JO - P L o S Medicine (Online)

JF - P L o S Medicine (Online)

SN - 1549-1277

IS - 8

M1 - e1003182

ER -

ID: 248334216