Characterization of the Hypothalamic-Pituitary-Adrenal-Axis in Familial Longevity under Resting Conditions

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Characterization of the Hypothalamic-Pituitary-Adrenal-Axis in Familial Longevity under Resting Conditions. / Jansen, Steffy W; Roelfsema, Ferdinand; Akintola, Abimbola A; Oei, Nicole Y; Cobbaert, Christa M; Ballieux, Bart E; van der Grond, Jeroen; Westendorp, Rudi G; Pijl, Hanno; van Heemst, Diana.

In: PLOS ONE, Vol. 10, No. 7, e0133119, 20.07.2015, p. 1-15.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Jansen, SW, Roelfsema, F, Akintola, AA, Oei, NY, Cobbaert, CM, Ballieux, BE, van der Grond, J, Westendorp, RG, Pijl, H & van Heemst, D 2015, 'Characterization of the Hypothalamic-Pituitary-Adrenal-Axis in Familial Longevity under Resting Conditions', PLOS ONE, vol. 10, no. 7, e0133119, pp. 1-15. https://doi.org/10.1371/journal.pone.0133119

APA

Jansen, S. W., Roelfsema, F., Akintola, A. A., Oei, N. Y., Cobbaert, C. M., Ballieux, B. E., ... van Heemst, D. (2015). Characterization of the Hypothalamic-Pituitary-Adrenal-Axis in Familial Longevity under Resting Conditions. PLOS ONE, 10(7), 1-15. [e0133119]. https://doi.org/10.1371/journal.pone.0133119

Vancouver

Jansen SW, Roelfsema F, Akintola AA, Oei NY, Cobbaert CM, Ballieux BE et al. Characterization of the Hypothalamic-Pituitary-Adrenal-Axis in Familial Longevity under Resting Conditions. PLOS ONE. 2015 Jul 20;10(7):1-15. e0133119. https://doi.org/10.1371/journal.pone.0133119

Author

Jansen, Steffy W ; Roelfsema, Ferdinand ; Akintola, Abimbola A ; Oei, Nicole Y ; Cobbaert, Christa M ; Ballieux, Bart E ; van der Grond, Jeroen ; Westendorp, Rudi G ; Pijl, Hanno ; van Heemst, Diana. / Characterization of the Hypothalamic-Pituitary-Adrenal-Axis in Familial Longevity under Resting Conditions. In: PLOS ONE. 2015 ; Vol. 10, No. 7. pp. 1-15.

Bibtex

@article{dde9e96eadb243d69277f7927147fd00,
title = "Characterization of the Hypothalamic-Pituitary-Adrenal-Axis in Familial Longevity under Resting Conditions",
abstract = "OBJECTIVE: The hypothalamic-pituitary-adrenal (HPA)-axis is the most important neuro-endocrine stress response system of our body which is of critical importance for survival. Disturbances in HPA-axis activity have been associated with adverse metabolic and cognitive changes. Humans enriched for longevity have less metabolic and cognitive disturbances and therefore diminished activity of the HPA axis may be a potential candidate mechanism underlying healthy familial longevity. Here, we compared 24-h plasma ACTH and serum cortisol concentration profiles and different aspects of the regulation of the HPA-axis in offspring from long-lived siblings, who are enriched for familial longevity and age-matched controls.DESIGN: Case-control study within the Leiden Longevity study cohort consisting of 20 middle-aged offspring of nonagenarian siblings (offspring) together with 18 partners (controls).METHODS: During 24 h, venous blood was sampled every 10 minutes for determination of circulatory ACTH and cortisol concentrations. Deconvolution analysis, cross approximate entropy analysis and ACTH-cortisol-dose response modeling were used to assess, respectively, ACTH and cortisol secretion parameters, feedforward and feedback synchrony and adrenal gland ACTH responsivity.RESULTS: Mean (95{\%} Confidence Interval) basal ACTH secretion was higher in male offspring compared to male controls (645 (324-1286) ngl/L/24 h versus 240 (120-477) ng/L/24 h, P = 0.05). Other ACTH and cortisol secretion parameters did not differ between offspring and controls. In addition, no significant differences in feedforward and feedback synchrony and adrenal gland ACTH responsivity were observed between groups.CONCLUSIONS: These results suggest that familial longevity is not associated with major differences in HPA-axis activity under resting conditions, although modest, sex-specific differences may exist between groups that might be clinically relevant.",
author = "Jansen, {Steffy W} and Ferdinand Roelfsema and Akintola, {Abimbola A} and Oei, {Nicole Y} and Cobbaert, {Christa M} and Ballieux, {Bart E} and {van der Grond}, Jeroen and Westendorp, {Rudi G} and Hanno Pijl and {van Heemst}, Diana",
year = "2015",
month = "7",
day = "20",
doi = "10.1371/journal.pone.0133119",
language = "English",
volume = "10",
pages = "1--15",
journal = "P L o S One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "7",

}

RIS

TY - JOUR

T1 - Characterization of the Hypothalamic-Pituitary-Adrenal-Axis in Familial Longevity under Resting Conditions

AU - Jansen, Steffy W

AU - Roelfsema, Ferdinand

AU - Akintola, Abimbola A

AU - Oei, Nicole Y

AU - Cobbaert, Christa M

AU - Ballieux, Bart E

AU - van der Grond, Jeroen

AU - Westendorp, Rudi G

AU - Pijl, Hanno

AU - van Heemst, Diana

PY - 2015/7/20

Y1 - 2015/7/20

N2 - OBJECTIVE: The hypothalamic-pituitary-adrenal (HPA)-axis is the most important neuro-endocrine stress response system of our body which is of critical importance for survival. Disturbances in HPA-axis activity have been associated with adverse metabolic and cognitive changes. Humans enriched for longevity have less metabolic and cognitive disturbances and therefore diminished activity of the HPA axis may be a potential candidate mechanism underlying healthy familial longevity. Here, we compared 24-h plasma ACTH and serum cortisol concentration profiles and different aspects of the regulation of the HPA-axis in offspring from long-lived siblings, who are enriched for familial longevity and age-matched controls.DESIGN: Case-control study within the Leiden Longevity study cohort consisting of 20 middle-aged offspring of nonagenarian siblings (offspring) together with 18 partners (controls).METHODS: During 24 h, venous blood was sampled every 10 minutes for determination of circulatory ACTH and cortisol concentrations. Deconvolution analysis, cross approximate entropy analysis and ACTH-cortisol-dose response modeling were used to assess, respectively, ACTH and cortisol secretion parameters, feedforward and feedback synchrony and adrenal gland ACTH responsivity.RESULTS: Mean (95% Confidence Interval) basal ACTH secretion was higher in male offspring compared to male controls (645 (324-1286) ngl/L/24 h versus 240 (120-477) ng/L/24 h, P = 0.05). Other ACTH and cortisol secretion parameters did not differ between offspring and controls. In addition, no significant differences in feedforward and feedback synchrony and adrenal gland ACTH responsivity were observed between groups.CONCLUSIONS: These results suggest that familial longevity is not associated with major differences in HPA-axis activity under resting conditions, although modest, sex-specific differences may exist between groups that might be clinically relevant.

AB - OBJECTIVE: The hypothalamic-pituitary-adrenal (HPA)-axis is the most important neuro-endocrine stress response system of our body which is of critical importance for survival. Disturbances in HPA-axis activity have been associated with adverse metabolic and cognitive changes. Humans enriched for longevity have less metabolic and cognitive disturbances and therefore diminished activity of the HPA axis may be a potential candidate mechanism underlying healthy familial longevity. Here, we compared 24-h plasma ACTH and serum cortisol concentration profiles and different aspects of the regulation of the HPA-axis in offspring from long-lived siblings, who are enriched for familial longevity and age-matched controls.DESIGN: Case-control study within the Leiden Longevity study cohort consisting of 20 middle-aged offspring of nonagenarian siblings (offspring) together with 18 partners (controls).METHODS: During 24 h, venous blood was sampled every 10 minutes for determination of circulatory ACTH and cortisol concentrations. Deconvolution analysis, cross approximate entropy analysis and ACTH-cortisol-dose response modeling were used to assess, respectively, ACTH and cortisol secretion parameters, feedforward and feedback synchrony and adrenal gland ACTH responsivity.RESULTS: Mean (95% Confidence Interval) basal ACTH secretion was higher in male offspring compared to male controls (645 (324-1286) ngl/L/24 h versus 240 (120-477) ng/L/24 h, P = 0.05). Other ACTH and cortisol secretion parameters did not differ between offspring and controls. In addition, no significant differences in feedforward and feedback synchrony and adrenal gland ACTH responsivity were observed between groups.CONCLUSIONS: These results suggest that familial longevity is not associated with major differences in HPA-axis activity under resting conditions, although modest, sex-specific differences may exist between groups that might be clinically relevant.

U2 - 10.1371/journal.pone.0133119

DO - 10.1371/journal.pone.0133119

M3 - Journal article

VL - 10

SP - 1

EP - 15

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 7

M1 - e0133119

ER -

ID: 141479691