Childcare attendance and risk of childhood acute lymphoblastic leukaemia: A register study based on the Danish Childcare Database

Research output: Contribution to journalJournal articlepeer-review

Standard

Childcare attendance and risk of childhood acute lymphoblastic leukaemia : A register study based on the Danish Childcare Database. / Søegaard, Signe Holst; Rostgaard, Klaus; Kamper-Jørgensen, Mads; Schmiegelow, Kjeld; Hjalgrim, Henrik.

In: International Journal of Cancer, Vol. 152, No. 9, 2023, p. 1817-1826.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Søegaard, SH, Rostgaard, K, Kamper-Jørgensen, M, Schmiegelow, K & Hjalgrim, H 2023, 'Childcare attendance and risk of childhood acute lymphoblastic leukaemia: A register study based on the Danish Childcare Database', International Journal of Cancer, vol. 152, no. 9, pp. 1817-1826. https://doi.org/10.1002/ijc.34413

APA

Søegaard, S. H., Rostgaard, K., Kamper-Jørgensen, M., Schmiegelow, K., & Hjalgrim, H. (2023). Childcare attendance and risk of childhood acute lymphoblastic leukaemia: A register study based on the Danish Childcare Database. International Journal of Cancer, 152(9), 1817-1826. https://doi.org/10.1002/ijc.34413

Vancouver

Søegaard SH, Rostgaard K, Kamper-Jørgensen M, Schmiegelow K, Hjalgrim H. Childcare attendance and risk of childhood acute lymphoblastic leukaemia: A register study based on the Danish Childcare Database. International Journal of Cancer. 2023;152(9):1817-1826. https://doi.org/10.1002/ijc.34413

Author

Søegaard, Signe Holst ; Rostgaard, Klaus ; Kamper-Jørgensen, Mads ; Schmiegelow, Kjeld ; Hjalgrim, Henrik. / Childcare attendance and risk of childhood acute lymphoblastic leukaemia : A register study based on the Danish Childcare Database. In: International Journal of Cancer. 2023 ; Vol. 152, No. 9. pp. 1817-1826.

Bibtex

@article{0b97d837bb18460190bbae2c5f3bdc52,
title = "Childcare attendance and risk of childhood acute lymphoblastic leukaemia: A register study based on the Danish Childcare Database",
abstract = "Childhood acute lymphoblastic leukaemia (ALL) is suggested to result from a dysregulated immune response to infections in children with a preleukaemic state. Childcare in early life supposedly may protect against childhood ALL by facilitating sufficient exposure to infections to stimulate and ensure normal maturation of the immune system. We assessed the association between childcare attendance before age two years and risk of childhood ALL in a register-based cohort study, including all children aged 2-14 years born in Denmark during 1991-2014 with available childcare information recorded in the Danish Childcare Database (n=1,116,185). Cox regression was used to estimate hazard ratios (HRs) comparing children enrolled in childcare and children not enrolled before age two years. Further, we assessed the association according to age at enrolment, type of childcare facility and specific ALL subtypes. During 10,460,811 person-years of follow-up, 460 children developed ALL at ages 2-14 years. Of these, 57 (12.4%) never attended childcare before age two years compared with 10.6% in the total cohort. Compared with homecare, childcare attendance before age two years was associated with a statistically non-significantly, marginally decreased risk of childhood ALL with adjusted HR = 0.87 (95% confidence interval (CI): 0.65-1.16). Risk estimates did neither vary statistically significantly by age at enrolment nor by type of childcare facility and also not between childhood ALL subtypes, including frequently prenatally initiated ALL subtypes. Results from this large, nationwide register-based study provided no evidence that childcare attendance in the first years of life protects against childhood ALL.",
author = "S{\o}egaard, {Signe Holst} and Klaus Rostgaard and Mads Kamper-J{\o}rgensen and Kjeld Schmiegelow and Henrik Hjalgrim",
note = "This article is protected by copyright. All rights reserved.",
year = "2023",
doi = "10.1002/ijc.34413",
language = "English",
volume = "152",
pages = "1817--1826",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley",
number = "9",

}

RIS

TY - JOUR

T1 - Childcare attendance and risk of childhood acute lymphoblastic leukaemia

T2 - A register study based on the Danish Childcare Database

AU - Søegaard, Signe Holst

AU - Rostgaard, Klaus

AU - Kamper-Jørgensen, Mads

AU - Schmiegelow, Kjeld

AU - Hjalgrim, Henrik

N1 - This article is protected by copyright. All rights reserved.

PY - 2023

Y1 - 2023

N2 - Childhood acute lymphoblastic leukaemia (ALL) is suggested to result from a dysregulated immune response to infections in children with a preleukaemic state. Childcare in early life supposedly may protect against childhood ALL by facilitating sufficient exposure to infections to stimulate and ensure normal maturation of the immune system. We assessed the association between childcare attendance before age two years and risk of childhood ALL in a register-based cohort study, including all children aged 2-14 years born in Denmark during 1991-2014 with available childcare information recorded in the Danish Childcare Database (n=1,116,185). Cox regression was used to estimate hazard ratios (HRs) comparing children enrolled in childcare and children not enrolled before age two years. Further, we assessed the association according to age at enrolment, type of childcare facility and specific ALL subtypes. During 10,460,811 person-years of follow-up, 460 children developed ALL at ages 2-14 years. Of these, 57 (12.4%) never attended childcare before age two years compared with 10.6% in the total cohort. Compared with homecare, childcare attendance before age two years was associated with a statistically non-significantly, marginally decreased risk of childhood ALL with adjusted HR = 0.87 (95% confidence interval (CI): 0.65-1.16). Risk estimates did neither vary statistically significantly by age at enrolment nor by type of childcare facility and also not between childhood ALL subtypes, including frequently prenatally initiated ALL subtypes. Results from this large, nationwide register-based study provided no evidence that childcare attendance in the first years of life protects against childhood ALL.

AB - Childhood acute lymphoblastic leukaemia (ALL) is suggested to result from a dysregulated immune response to infections in children with a preleukaemic state. Childcare in early life supposedly may protect against childhood ALL by facilitating sufficient exposure to infections to stimulate and ensure normal maturation of the immune system. We assessed the association between childcare attendance before age two years and risk of childhood ALL in a register-based cohort study, including all children aged 2-14 years born in Denmark during 1991-2014 with available childcare information recorded in the Danish Childcare Database (n=1,116,185). Cox regression was used to estimate hazard ratios (HRs) comparing children enrolled in childcare and children not enrolled before age two years. Further, we assessed the association according to age at enrolment, type of childcare facility and specific ALL subtypes. During 10,460,811 person-years of follow-up, 460 children developed ALL at ages 2-14 years. Of these, 57 (12.4%) never attended childcare before age two years compared with 10.6% in the total cohort. Compared with homecare, childcare attendance before age two years was associated with a statistically non-significantly, marginally decreased risk of childhood ALL with adjusted HR = 0.87 (95% confidence interval (CI): 0.65-1.16). Risk estimates did neither vary statistically significantly by age at enrolment nor by type of childcare facility and also not between childhood ALL subtypes, including frequently prenatally initiated ALL subtypes. Results from this large, nationwide register-based study provided no evidence that childcare attendance in the first years of life protects against childhood ALL.

U2 - 10.1002/ijc.34413

DO - 10.1002/ijc.34413

M3 - Journal article

C2 - 36545888

VL - 152

SP - 1817

EP - 1826

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 9

ER -

ID: 330061949