Childhood dyspraxia predicts adult-onset nonaffective-psychosis-spectrum disorder

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Childhood dyspraxia predicts adult-onset nonaffective-psychosis-spectrum disorder. / Schiffman, Jason; Mittal, Vijay; Kline, Emily; Mortensen, Erik L.; Michelsen, Niels; Ekstrom, Morten; Millman, Zachary B.; Mednick, Sarnoff A.; Sorensen, Holger J.

In: Development and Psychopathology, Vol. 27, No. 4, 2015, p. 1323-1330.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Schiffman, J, Mittal, V, Kline, E, Mortensen, EL, Michelsen, N, Ekstrom, M, Millman, ZB, Mednick, SA & Sorensen, HJ 2015, 'Childhood dyspraxia predicts adult-onset nonaffective-psychosis-spectrum disorder', Development and Psychopathology, vol. 27, no. 4, pp. 1323-1330. https://doi.org/10.1017/S0954579414001436

APA

Schiffman, J., Mittal, V., Kline, E., Mortensen, E. L., Michelsen, N., Ekstrom, M., Millman, Z. B., Mednick, S. A., & Sorensen, H. J. (2015). Childhood dyspraxia predicts adult-onset nonaffective-psychosis-spectrum disorder. Development and Psychopathology, 27(4), 1323-1330. https://doi.org/10.1017/S0954579414001436

Vancouver

Schiffman J, Mittal V, Kline E, Mortensen EL, Michelsen N, Ekstrom M et al. Childhood dyspraxia predicts adult-onset nonaffective-psychosis-spectrum disorder. Development and Psychopathology. 2015;27(4):1323-1330. https://doi.org/10.1017/S0954579414001436

Author

Schiffman, Jason ; Mittal, Vijay ; Kline, Emily ; Mortensen, Erik L. ; Michelsen, Niels ; Ekstrom, Morten ; Millman, Zachary B. ; Mednick, Sarnoff A. ; Sorensen, Holger J. / Childhood dyspraxia predicts adult-onset nonaffective-psychosis-spectrum disorder. In: Development and Psychopathology. 2015 ; Vol. 27, No. 4. pp. 1323-1330.

Bibtex

@article{ad91cdb5c3fd47e698feb3dfd35c10a3,
title = "Childhood dyspraxia predicts adult-onset nonaffective-psychosis-spectrum disorder",
abstract = "Several neurological variables have been investigated as premorbid biomarkers of vulnerability for schizophrenia and other related disorders. The current study examined whether childhood dyspraxia predicted later adult nonaffective-psychosis-spectrum disorders. From a standardized neurological examination performed with children (aged 10-13) at genetic high risk of schizophrenia and controls, several measures of dyspraxia were used to create a scale composed of face/head dyspraxia, oral articulation, ideomotor dyspraxia (clumsiness), and dressing dyspraxia (n = 244). Multinomial logistic regression showed higher scores on the dyspraxia scale predict nonaffective-psychosis-spectrum disorders relative to other psychiatric disorders and no mental illness outcomes, even after controlling for genetic risk, χ2 (4, 244) = 18.61, p <.001. Findings that symptoms of dyspraxia in childhood (reflecting abnormalities spanning functionally distinct brain networks) specifically predict adult nonaffective-psychosis-spectrum disorders are consistent with a theory of abnormal connectivity, and they highlight a marked early-stage vulnerability in the pathophysiology of nonaffective-psychosis-spectrum disorders.",
author = "Jason Schiffman and Vijay Mittal and Emily Kline and Mortensen, {Erik L.} and Niels Michelsen and Morten Ekstrom and Millman, {Zachary B.} and Mednick, {Sarnoff A.} and Sorensen, {Holger J.}",
year = "2015",
doi = "10.1017/S0954579414001436",
language = "English",
volume = "27",
pages = "1323--1330",
journal = "Development and Psychopathology",
issn = "0954-5794",
publisher = "Cambridge University Press",
number = "4",

}

RIS

TY - JOUR

T1 - Childhood dyspraxia predicts adult-onset nonaffective-psychosis-spectrum disorder

AU - Schiffman, Jason

AU - Mittal, Vijay

AU - Kline, Emily

AU - Mortensen, Erik L.

AU - Michelsen, Niels

AU - Ekstrom, Morten

AU - Millman, Zachary B.

AU - Mednick, Sarnoff A.

AU - Sorensen, Holger J.

PY - 2015

Y1 - 2015

N2 - Several neurological variables have been investigated as premorbid biomarkers of vulnerability for schizophrenia and other related disorders. The current study examined whether childhood dyspraxia predicted later adult nonaffective-psychosis-spectrum disorders. From a standardized neurological examination performed with children (aged 10-13) at genetic high risk of schizophrenia and controls, several measures of dyspraxia were used to create a scale composed of face/head dyspraxia, oral articulation, ideomotor dyspraxia (clumsiness), and dressing dyspraxia (n = 244). Multinomial logistic regression showed higher scores on the dyspraxia scale predict nonaffective-psychosis-spectrum disorders relative to other psychiatric disorders and no mental illness outcomes, even after controlling for genetic risk, χ2 (4, 244) = 18.61, p <.001. Findings that symptoms of dyspraxia in childhood (reflecting abnormalities spanning functionally distinct brain networks) specifically predict adult nonaffective-psychosis-spectrum disorders are consistent with a theory of abnormal connectivity, and they highlight a marked early-stage vulnerability in the pathophysiology of nonaffective-psychosis-spectrum disorders.

AB - Several neurological variables have been investigated as premorbid biomarkers of vulnerability for schizophrenia and other related disorders. The current study examined whether childhood dyspraxia predicted later adult nonaffective-psychosis-spectrum disorders. From a standardized neurological examination performed with children (aged 10-13) at genetic high risk of schizophrenia and controls, several measures of dyspraxia were used to create a scale composed of face/head dyspraxia, oral articulation, ideomotor dyspraxia (clumsiness), and dressing dyspraxia (n = 244). Multinomial logistic regression showed higher scores on the dyspraxia scale predict nonaffective-psychosis-spectrum disorders relative to other psychiatric disorders and no mental illness outcomes, even after controlling for genetic risk, χ2 (4, 244) = 18.61, p <.001. Findings that symptoms of dyspraxia in childhood (reflecting abnormalities spanning functionally distinct brain networks) specifically predict adult nonaffective-psychosis-spectrum disorders are consistent with a theory of abnormal connectivity, and they highlight a marked early-stage vulnerability in the pathophysiology of nonaffective-psychosis-spectrum disorders.

U2 - 10.1017/S0954579414001436

DO - 10.1017/S0954579414001436

M3 - Journal article

C2 - 26439077

AN - SCOPUS:84973311129

VL - 27

SP - 1323

EP - 1330

JO - Development and Psychopathology

JF - Development and Psychopathology

SN - 0954-5794

IS - 4

ER -

ID: 203889712