Clustered tuberculosis in a low-burden country: nationwide genotyping through 15 years

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Clustered tuberculosis in a low-burden country : nationwide genotyping through 15 years. / Kamper-Jørgensen, Z; Andersen, A B; Kok-Jensen, A; Bygbjerg, I C; Andersen, P H; Thomsen, V O; Kamper-Jørgensen, Mads; Lillebaek, T.

In: Journal of Clinical Microbiology, Vol. 50, No. 8, 2012, p. 2660-2667.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Kamper-Jørgensen, Z, Andersen, AB, Kok-Jensen, A, Bygbjerg, IC, Andersen, PH, Thomsen, VO, Kamper-Jørgensen, M & Lillebaek, T 2012, 'Clustered tuberculosis in a low-burden country: nationwide genotyping through 15 years', Journal of Clinical Microbiology, vol. 50, no. 8, pp. 2660-2667. https://doi.org/10.1128/JCM.06358-11

APA

Kamper-Jørgensen, Z., Andersen, A. B., Kok-Jensen, A., Bygbjerg, I. C., Andersen, P. H., Thomsen, V. O., ... Lillebaek, T. (2012). Clustered tuberculosis in a low-burden country: nationwide genotyping through 15 years. Journal of Clinical Microbiology, 50(8), 2660-2667. https://doi.org/10.1128/JCM.06358-11

Vancouver

Kamper-Jørgensen Z, Andersen AB, Kok-Jensen A, Bygbjerg IC, Andersen PH, Thomsen VO et al. Clustered tuberculosis in a low-burden country: nationwide genotyping through 15 years. Journal of Clinical Microbiology. 2012;50(8):2660-2667. https://doi.org/10.1128/JCM.06358-11

Author

Kamper-Jørgensen, Z ; Andersen, A B ; Kok-Jensen, A ; Bygbjerg, I C ; Andersen, P H ; Thomsen, V O ; Kamper-Jørgensen, Mads ; Lillebaek, T. / Clustered tuberculosis in a low-burden country : nationwide genotyping through 15 years. In: Journal of Clinical Microbiology. 2012 ; Vol. 50, No. 8. pp. 2660-2667.

Bibtex

@article{ffcf580b5e2d4d449d851b13cf631729,
title = "Clustered tuberculosis in a low-burden country: nationwide genotyping through 15 years",
abstract = "Molecular genotyping of Mycobacterium tuberculosis has proved to be a powerful tool in tuberculosis surveillance, epidemiology, and control. Based on results obtained through 15 years of nationwide IS6110 restriction fragment length polymorphism (RFLP) genotyping of M. tuberculosis cases in Denmark, a country on the way toward tuberculosis elimination, we discuss M. tuberculosis transmission dynamics and point to areas for control interventions. Cases with 100{\%} identical genotypes (RFLP patterns) were defined as clustered, and a cluster was defined as cases with an identical genotype. Of 4,601 included cases, corresponding to 76{\%} of reported and 97{\%} of culture-verified tuberculosis cases in the country, 56{\%} were clustered, of which 69{\%} were Danes. Generally, Danes were more often in large clusters (= 50 persons), older (mean age, 45 years), and male (male/female ratio, 2.5). Also, Danes had a higher cluster frequency within a 2-year observation window (60.8{\%}), and higher clustering rate of new patterns over time, compared to immigrants. A dominant genotype, cluster 2, constituted 44{\%} of all clustered and 35{\%} of all genotyped cases. This cluster was primarily found among Danish males, 30 to 59 years of age, often socially marginalized, and with records of alcohol abuse. In Danes, cluster 2 alone was responsible for the high cluster frequency level. Immigrants had a higher incidence of clustered tuberculosis at a younger age (0 to 39 years). To achieve tuberculosis elimination in Denmark, high-risk transmission environments, like the cluster 2 environment in Danes, and specific transmission chains in immigrants in the capital area, e.g., homeless/socially marginalized Somalis/Greenlanders, often with alcohol abuse, must be targeted, including groups with a high risk of reactivation.",
keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Cluster Analysis, DNA Transposable Elements, DNA, Bacterial, Denmark, Female, Genotype, Humans, Infant, Infant, Newborn, Male, Middle Aged, Molecular Epidemiology, Molecular Typing, Mycobacterium tuberculosis, Polymorphism, Restriction Fragment Length, Retrospective Studies, Tuberculosis, Young Adult",
author = "Z Kamper-J{\o}rgensen and Andersen, {A B} and A Kok-Jensen and Bygbjerg, {I C} and Andersen, {P H} and Thomsen, {V O} and Mads Kamper-J{\o}rgensen and T Lillebaek",
year = "2012",
doi = "10.1128/JCM.06358-11",
language = "English",
volume = "50",
pages = "2660--2667",
journal = "Journal of Clinical Microbiology",
issn = "0095-1137",
publisher = "American Society for Microbiology",
number = "8",

}

RIS

TY - JOUR

T1 - Clustered tuberculosis in a low-burden country

T2 - nationwide genotyping through 15 years

AU - Kamper-Jørgensen, Z

AU - Andersen, A B

AU - Kok-Jensen, A

AU - Bygbjerg, I C

AU - Andersen, P H

AU - Thomsen, V O

AU - Kamper-Jørgensen, Mads

AU - Lillebaek, T

PY - 2012

Y1 - 2012

N2 - Molecular genotyping of Mycobacterium tuberculosis has proved to be a powerful tool in tuberculosis surveillance, epidemiology, and control. Based on results obtained through 15 years of nationwide IS6110 restriction fragment length polymorphism (RFLP) genotyping of M. tuberculosis cases in Denmark, a country on the way toward tuberculosis elimination, we discuss M. tuberculosis transmission dynamics and point to areas for control interventions. Cases with 100% identical genotypes (RFLP patterns) were defined as clustered, and a cluster was defined as cases with an identical genotype. Of 4,601 included cases, corresponding to 76% of reported and 97% of culture-verified tuberculosis cases in the country, 56% were clustered, of which 69% were Danes. Generally, Danes were more often in large clusters (= 50 persons), older (mean age, 45 years), and male (male/female ratio, 2.5). Also, Danes had a higher cluster frequency within a 2-year observation window (60.8%), and higher clustering rate of new patterns over time, compared to immigrants. A dominant genotype, cluster 2, constituted 44% of all clustered and 35% of all genotyped cases. This cluster was primarily found among Danish males, 30 to 59 years of age, often socially marginalized, and with records of alcohol abuse. In Danes, cluster 2 alone was responsible for the high cluster frequency level. Immigrants had a higher incidence of clustered tuberculosis at a younger age (0 to 39 years). To achieve tuberculosis elimination in Denmark, high-risk transmission environments, like the cluster 2 environment in Danes, and specific transmission chains in immigrants in the capital area, e.g., homeless/socially marginalized Somalis/Greenlanders, often with alcohol abuse, must be targeted, including groups with a high risk of reactivation.

AB - Molecular genotyping of Mycobacterium tuberculosis has proved to be a powerful tool in tuberculosis surveillance, epidemiology, and control. Based on results obtained through 15 years of nationwide IS6110 restriction fragment length polymorphism (RFLP) genotyping of M. tuberculosis cases in Denmark, a country on the way toward tuberculosis elimination, we discuss M. tuberculosis transmission dynamics and point to areas for control interventions. Cases with 100% identical genotypes (RFLP patterns) were defined as clustered, and a cluster was defined as cases with an identical genotype. Of 4,601 included cases, corresponding to 76% of reported and 97% of culture-verified tuberculosis cases in the country, 56% were clustered, of which 69% were Danes. Generally, Danes were more often in large clusters (= 50 persons), older (mean age, 45 years), and male (male/female ratio, 2.5). Also, Danes had a higher cluster frequency within a 2-year observation window (60.8%), and higher clustering rate of new patterns over time, compared to immigrants. A dominant genotype, cluster 2, constituted 44% of all clustered and 35% of all genotyped cases. This cluster was primarily found among Danish males, 30 to 59 years of age, often socially marginalized, and with records of alcohol abuse. In Danes, cluster 2 alone was responsible for the high cluster frequency level. Immigrants had a higher incidence of clustered tuberculosis at a younger age (0 to 39 years). To achieve tuberculosis elimination in Denmark, high-risk transmission environments, like the cluster 2 environment in Danes, and specific transmission chains in immigrants in the capital area, e.g., homeless/socially marginalized Somalis/Greenlanders, often with alcohol abuse, must be targeted, including groups with a high risk of reactivation.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Child

KW - Child, Preschool

KW - Cluster Analysis

KW - DNA Transposable Elements

KW - DNA, Bacterial

KW - Denmark

KW - Female

KW - Genotype

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Male

KW - Middle Aged

KW - Molecular Epidemiology

KW - Molecular Typing

KW - Mycobacterium tuberculosis

KW - Polymorphism, Restriction Fragment Length

KW - Retrospective Studies

KW - Tuberculosis

KW - Young Adult

U2 - 10.1128/JCM.06358-11

DO - 10.1128/JCM.06358-11

M3 - Journal article

C2 - 22675129

VL - 50

SP - 2660

EP - 2667

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

SN - 0095-1137

IS - 8

ER -

ID: 44258367