Combined Influence of Waist and Hip Circumference on Risk of Death in a Large Cohort of European and Australian Adults
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Combined Influence of Waist and Hip Circumference on Risk of Death in a Large Cohort of European and Australian Adults. / Cameron, Adrian J; Romaniuk, Helena; Orellana, Liliana; Dallongeville, Jean; Dobson, Annette J; Drygas, Wojciech; Ferrario, Marco; Ferrieres, Jean; Giampaoli, Simona; Gianfagna, Francesco; Iacoviello, Licia; Jousilahti, Pekka; Kee, Frank; Moitry, Marie; Niiranen, Teemu J; Pająk, Andrzej; Palmieri, Luigi; Palosaari, Tarja; Satu, Männistö; Tamosiunas, Abdonas; Thorand, Barbara; Toft, Ulla; Vanuzzo, Diego; Veikko, Salomaa; Veronesi, Giovanni; Wilsgaard, Tom; Kuulasmaa, Kari; Söderberg, Stefan.
In: Journal of the American Heart Association, Vol. 9, No. 13, 07.07.2020, p. e015189.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - Combined Influence of Waist and Hip Circumference on Risk of Death in a Large Cohort of European and Australian Adults
AU - Cameron, Adrian J
AU - Romaniuk, Helena
AU - Orellana, Liliana
AU - Dallongeville, Jean
AU - Dobson, Annette J
AU - Drygas, Wojciech
AU - Ferrario, Marco
AU - Ferrieres, Jean
AU - Giampaoli, Simona
AU - Gianfagna, Francesco
AU - Iacoviello, Licia
AU - Jousilahti, Pekka
AU - Kee, Frank
AU - Moitry, Marie
AU - Niiranen, Teemu J
AU - Pająk, Andrzej
AU - Palmieri, Luigi
AU - Palosaari, Tarja
AU - Satu, Männistö
AU - Tamosiunas, Abdonas
AU - Thorand, Barbara
AU - Toft, Ulla
AU - Vanuzzo, Diego
AU - Veikko, Salomaa
AU - Veronesi, Giovanni
AU - Wilsgaard, Tom
AU - Kuulasmaa, Kari
AU - Söderberg, Stefan
PY - 2020/7/7
Y1 - 2020/7/7
N2 - Background Waist circumference and hip circumference are both strongly associated with risk of death; however, their joint association has rarely been investigated. Methods and Results The MONICA Risk, Genetics, Archiving, and Monograph (MORGAM) Project was conducted in 30 cohorts from 11 countries; 90 487 men and women, aged 30 to 74 years, predominantly white, with no history of cardiovascular disease, were recruited in 1986 to 2010 and followed up for up to 24 years. Hazard ratios were estimated using sex-specific Cox models, stratified by cohort, with age as the time scale. Models included baseline categorical obesity measures, age, total and high-density lipoprotein cholesterol, systolic blood pressure, antihypertensive drugs, smoking, and diabetes mellitus. A total of 9105 all-cause deaths were recorded during a median follow-up of 10 years. Hazard ratios for all-cause death presented J- or U-shaped associations with most obesity measures. With waist and hip circumference included in the same model, for all hip sizes, having a smaller waist was strongly associated with lower risk of death, except for men with the smallest hips. In addition, among those with smaller waists, hip size was strongly negatively associated with risk of death, with ≈20% more people identified as being at increased risk compared with waist circumference alone. Conclusions A more complex relationship between hip circumference, waist circumference, and risk of death is revealed when both measures are considered simultaneously. This is particularly true for individuals with smaller waists, where having larger hips was protective. Considering both waist and hip circumference in the clinical setting could help to best identify those at increased risk of death.
AB - Background Waist circumference and hip circumference are both strongly associated with risk of death; however, their joint association has rarely been investigated. Methods and Results The MONICA Risk, Genetics, Archiving, and Monograph (MORGAM) Project was conducted in 30 cohorts from 11 countries; 90 487 men and women, aged 30 to 74 years, predominantly white, with no history of cardiovascular disease, were recruited in 1986 to 2010 and followed up for up to 24 years. Hazard ratios were estimated using sex-specific Cox models, stratified by cohort, with age as the time scale. Models included baseline categorical obesity measures, age, total and high-density lipoprotein cholesterol, systolic blood pressure, antihypertensive drugs, smoking, and diabetes mellitus. A total of 9105 all-cause deaths were recorded during a median follow-up of 10 years. Hazard ratios for all-cause death presented J- or U-shaped associations with most obesity measures. With waist and hip circumference included in the same model, for all hip sizes, having a smaller waist was strongly associated with lower risk of death, except for men with the smallest hips. In addition, among those with smaller waists, hip size was strongly negatively associated with risk of death, with ≈20% more people identified as being at increased risk compared with waist circumference alone. Conclusions A more complex relationship between hip circumference, waist circumference, and risk of death is revealed when both measures are considered simultaneously. This is particularly true for individuals with smaller waists, where having larger hips was protective. Considering both waist and hip circumference in the clinical setting could help to best identify those at increased risk of death.
KW - Adiposity
KW - Adult
KW - Aged
KW - Australia/epidemiology
KW - Cardiovascular Diseases/diagnosis
KW - Cause of Death
KW - Europe/epidemiology
KW - Female
KW - Humans
KW - Incidence
KW - Male
KW - Middle Aged
KW - Obesity/diagnosis
KW - Predictive Value of Tests
KW - Prognosis
KW - Prospective Studies
KW - Protective Factors
KW - Risk Assessment
KW - Risk Factors
KW - Waist Circumference
KW - Waist-Hip Ratio
U2 - 10.1161/JAHA.119.015189
DO - 10.1161/JAHA.119.015189
M3 - Journal article
C2 - 32602397
VL - 9
SP - e015189
JO - Journal of the American Heart Association
JF - Journal of the American Heart Association
SN - 2047-9980
IS - 13
ER -
ID: 259567698