Dietary magnesium deficiency affects gut microbiota and anxiety-like behaviour in C57BL/6N mice

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Dietary magnesium deficiency affects gut microbiota and anxiety-like behaviour in C57BL/6N mice. / Jørgensen, Bettina Merete Pyndt; Winther, Gudrun; Kihl, Pernille; Nielsen, Dennis Sandris; Wegener, Gregers; Hansen, Axel Kornerup; Sørensen, Dorte Bratbo.

In: Acta Neuropsychiatrica (Print), Vol. 27, No. 5, 2015, p. 307-311.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Jørgensen, BMP, Winther, G, Kihl, P, Nielsen, DS, Wegener, G, Hansen, AK & Sørensen, DB 2015, 'Dietary magnesium deficiency affects gut microbiota and anxiety-like behaviour in C57BL/6N mice', Acta Neuropsychiatrica (Print), vol. 27, no. 5, pp. 307-311. https://doi.org/10.1017/neu.2015.10

APA

Jørgensen, B. M. P., Winther, G., Kihl, P., Nielsen, D. S., Wegener, G., Hansen, A. K., & Sørensen, D. B. (2015). Dietary magnesium deficiency affects gut microbiota and anxiety-like behaviour in C57BL/6N mice. Acta Neuropsychiatrica (Print), 27(5), 307-311. https://doi.org/10.1017/neu.2015.10

Vancouver

Jørgensen BMP, Winther G, Kihl P, Nielsen DS, Wegener G, Hansen AK et al. Dietary magnesium deficiency affects gut microbiota and anxiety-like behaviour in C57BL/6N mice. Acta Neuropsychiatrica (Print). 2015;27(5):307-311. https://doi.org/10.1017/neu.2015.10

Author

Jørgensen, Bettina Merete Pyndt ; Winther, Gudrun ; Kihl, Pernille ; Nielsen, Dennis Sandris ; Wegener, Gregers ; Hansen, Axel Kornerup ; Sørensen, Dorte Bratbo. / Dietary magnesium deficiency affects gut microbiota and anxiety-like behaviour in C57BL/6N mice. In: Acta Neuropsychiatrica (Print). 2015 ; Vol. 27, No. 5. pp. 307-311.

Bibtex

@article{215f9d84b1924c8faed595cc47f8d9c5,
title = "Dietary magnesium deficiency affects gut microbiota and anxiety-like behaviour in C57BL/6N mice",
abstract = "OBJECTIVE: Magnesium deficiency has been associated with anxiety in humans, and rodent studies have demonstrated the gut microbiota to impact behaviour.METHODS: We investigated the impact of 6 weeks of dietary magnesium deficiency on gut microbiota composition and anxiety-like behaviour and whether there was a link between the two. A total of 20 C57BL/6 mice, fed either a standard diet or a magnesium-deficient diet for 6 weeks, were tested using the light-dark box anxiety test. Gut microbiota composition was analysed by denaturation gradient gel electrophoresis.RESULTS: We demonstrated that the gut microbiota composition correlated significantly with the behaviour of dietary unchallenged mice. A magnesium-deficient diet altered the gut microbiota, and was associated with altered anxiety-like behaviour, measured by decreased latency to enter the light box.CONCLUSION: Magnesium deficiency altered behavior. The duration of magnesium deficiency is suggested to influence behaviour in the evaluated test.",
keywords = "Faculty of Health and Medical Sciences, animal models, anxiety, gut microbiota, magnesium",
author = "J{\o}rgensen, {Bettina Merete Pyndt} and Gudrun Winther and Pernille Kihl and Nielsen, {Dennis Sandris} and Gregers Wegener and Hansen, {Axel Kornerup} and S{\o}rensen, {Dorte Bratbo}",
year = "2015",
doi = "10.1017/neu.2015.10",
language = "English",
volume = "27",
pages = "307--311",
journal = "Acta Neuropsychiatrica",
issn = "0924-2708",
publisher = "Cambridge University Press",
number = "5",

}

RIS

TY - JOUR

T1 - Dietary magnesium deficiency affects gut microbiota and anxiety-like behaviour in C57BL/6N mice

AU - Jørgensen, Bettina Merete Pyndt

AU - Winther, Gudrun

AU - Kihl, Pernille

AU - Nielsen, Dennis Sandris

AU - Wegener, Gregers

AU - Hansen, Axel Kornerup

AU - Sørensen, Dorte Bratbo

PY - 2015

Y1 - 2015

N2 - OBJECTIVE: Magnesium deficiency has been associated with anxiety in humans, and rodent studies have demonstrated the gut microbiota to impact behaviour.METHODS: We investigated the impact of 6 weeks of dietary magnesium deficiency on gut microbiota composition and anxiety-like behaviour and whether there was a link between the two. A total of 20 C57BL/6 mice, fed either a standard diet or a magnesium-deficient diet for 6 weeks, were tested using the light-dark box anxiety test. Gut microbiota composition was analysed by denaturation gradient gel electrophoresis.RESULTS: We demonstrated that the gut microbiota composition correlated significantly with the behaviour of dietary unchallenged mice. A magnesium-deficient diet altered the gut microbiota, and was associated with altered anxiety-like behaviour, measured by decreased latency to enter the light box.CONCLUSION: Magnesium deficiency altered behavior. The duration of magnesium deficiency is suggested to influence behaviour in the evaluated test.

AB - OBJECTIVE: Magnesium deficiency has been associated with anxiety in humans, and rodent studies have demonstrated the gut microbiota to impact behaviour.METHODS: We investigated the impact of 6 weeks of dietary magnesium deficiency on gut microbiota composition and anxiety-like behaviour and whether there was a link between the two. A total of 20 C57BL/6 mice, fed either a standard diet or a magnesium-deficient diet for 6 weeks, were tested using the light-dark box anxiety test. Gut microbiota composition was analysed by denaturation gradient gel electrophoresis.RESULTS: We demonstrated that the gut microbiota composition correlated significantly with the behaviour of dietary unchallenged mice. A magnesium-deficient diet altered the gut microbiota, and was associated with altered anxiety-like behaviour, measured by decreased latency to enter the light box.CONCLUSION: Magnesium deficiency altered behavior. The duration of magnesium deficiency is suggested to influence behaviour in the evaluated test.

KW - Faculty of Health and Medical Sciences

KW - animal models

KW - anxiety

KW - gut microbiota

KW - magnesium

U2 - 10.1017/neu.2015.10

DO - 10.1017/neu.2015.10

M3 - Journal article

C2 - 25773775

VL - 27

SP - 307

EP - 311

JO - Acta Neuropsychiatrica

JF - Acta Neuropsychiatrica

SN - 0924-2708

IS - 5

ER -

ID: 144794944