Dietary protein and urinary nitrogen in relation to 6-year changes in fat mass and fat-free mass

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Dietary protein and urinary nitrogen in relation to 6-year changes in fat mass and fat-free mass. / Ankarfeldt, Mikkel Zøllner; Gottliebsen, K; Ängquist, L; Astrup, Arne; Heitmann, B L; Sørensen, Thorkild I.A.

In: International Journal of Obesity, Vol. 39, No. 1, 2015, p. 162-168.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Ankarfeldt, MZ, Gottliebsen, K, Ängquist, L, Astrup, A, Heitmann, BL & Sørensen, TIA 2015, 'Dietary protein and urinary nitrogen in relation to 6-year changes in fat mass and fat-free mass', International Journal of Obesity, vol. 39, no. 1, pp. 162-168. https://doi.org/10.1038/ijo.2014.80

APA

Ankarfeldt, M. Z., Gottliebsen, K., Ängquist, L., Astrup, A., Heitmann, B. L., & Sørensen, T. I. A. (2015). Dietary protein and urinary nitrogen in relation to 6-year changes in fat mass and fat-free mass. International Journal of Obesity, 39(1), 162-168. https://doi.org/10.1038/ijo.2014.80

Vancouver

Ankarfeldt MZ, Gottliebsen K, Ängquist L, Astrup A, Heitmann BL, Sørensen TIA. Dietary protein and urinary nitrogen in relation to 6-year changes in fat mass and fat-free mass. International Journal of Obesity. 2015;39(1):162-168. https://doi.org/10.1038/ijo.2014.80

Author

Ankarfeldt, Mikkel Zøllner ; Gottliebsen, K ; Ängquist, L ; Astrup, Arne ; Heitmann, B L ; Sørensen, Thorkild I.A. / Dietary protein and urinary nitrogen in relation to 6-year changes in fat mass and fat-free mass. In: International Journal of Obesity. 2015 ; Vol. 39, No. 1. pp. 162-168.

Bibtex

@article{6c29eeec6b0f4d6ea90e71a994303bab,
title = "Dietary protein and urinary nitrogen in relation to 6-year changes in fat mass and fat-free mass",
abstract = "Background:In contrast to the physiological expectation, observational studies show that greater protein intake is associated with subsequent body weight (BW) gain. An increase in fat-free mass (FFM) due to anabolic effects of protein could explain this.Objective:To examine associations between protein intake and subsequent changes in fat mass (FM) and FFM in longitudinal, observational data.Design:A health examination, including measures of FM and FFM by bioelectrical impedance at baseline and follow-up six years later, was conducted. Diet history interviews (DHI) were performed, and 24-hour urinary nitrogen collection at baseline was done. In total, 330 participants with DHI, of whom 227 had validated and complete 24-hour urine collection, were analyzed. Macronutrient energy substitution models were used.Results:Mean estimated protein intake was 14.6 E% from DHI and 11.3 E% from urinary nitrogen. Estimated from DHI, FM increased 46 gram/year with every 1 E% protein substituted for fat (95%CI: 13, 79; P=0.006) and FFM increased 15 gram/year (1, 30; P=0.046). Results were similar in other substitution models. Estimated from urinary nitrogen, FM increased 53 gram/year with 1 E% protein substituted for other macronutrients (24, 81; p<0.0005), and FFM increased 18 gram/year (6, 31; P=0.004).Conclusion:Within a habitual range, a greater protein intake was associated with BW gain, mostly in FM. This is in contrast to the expectations based on physiological and clinical trials, and calls for a better understanding of how habitual dietary protein influences long-term energy balance, versus how greater changes in dietary proteins may influence short-term energy balance.International Journal of Obesity accepted article preview online, 20 May 2014; doi:10.1038/ijo.2014.80.",
author = "Ankarfeldt, {Mikkel Z{\o}llner} and K Gottliebsen and L {\"A}ngquist and Arne Astrup and Heitmann, {B L} and S{\o}rensen, {Thorkild I.A.}",
note = "CURIS 2015 NEXS 023",
year = "2015",
doi = "10.1038/ijo.2014.80",
language = "English",
volume = "39",
pages = "162--168",
journal = "International Journal of Obesity",
issn = "0307-0565",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Dietary protein and urinary nitrogen in relation to 6-year changes in fat mass and fat-free mass

AU - Ankarfeldt, Mikkel Zøllner

AU - Gottliebsen, K

AU - Ängquist, L

AU - Astrup, Arne

AU - Heitmann, B L

AU - Sørensen, Thorkild I.A.

N1 - CURIS 2015 NEXS 023

PY - 2015

Y1 - 2015

N2 - Background:In contrast to the physiological expectation, observational studies show that greater protein intake is associated with subsequent body weight (BW) gain. An increase in fat-free mass (FFM) due to anabolic effects of protein could explain this.Objective:To examine associations between protein intake and subsequent changes in fat mass (FM) and FFM in longitudinal, observational data.Design:A health examination, including measures of FM and FFM by bioelectrical impedance at baseline and follow-up six years later, was conducted. Diet history interviews (DHI) were performed, and 24-hour urinary nitrogen collection at baseline was done. In total, 330 participants with DHI, of whom 227 had validated and complete 24-hour urine collection, were analyzed. Macronutrient energy substitution models were used.Results:Mean estimated protein intake was 14.6 E% from DHI and 11.3 E% from urinary nitrogen. Estimated from DHI, FM increased 46 gram/year with every 1 E% protein substituted for fat (95%CI: 13, 79; P=0.006) and FFM increased 15 gram/year (1, 30; P=0.046). Results were similar in other substitution models. Estimated from urinary nitrogen, FM increased 53 gram/year with 1 E% protein substituted for other macronutrients (24, 81; p<0.0005), and FFM increased 18 gram/year (6, 31; P=0.004).Conclusion:Within a habitual range, a greater protein intake was associated with BW gain, mostly in FM. This is in contrast to the expectations based on physiological and clinical trials, and calls for a better understanding of how habitual dietary protein influences long-term energy balance, versus how greater changes in dietary proteins may influence short-term energy balance.International Journal of Obesity accepted article preview online, 20 May 2014; doi:10.1038/ijo.2014.80.

AB - Background:In contrast to the physiological expectation, observational studies show that greater protein intake is associated with subsequent body weight (BW) gain. An increase in fat-free mass (FFM) due to anabolic effects of protein could explain this.Objective:To examine associations between protein intake and subsequent changes in fat mass (FM) and FFM in longitudinal, observational data.Design:A health examination, including measures of FM and FFM by bioelectrical impedance at baseline and follow-up six years later, was conducted. Diet history interviews (DHI) were performed, and 24-hour urinary nitrogen collection at baseline was done. In total, 330 participants with DHI, of whom 227 had validated and complete 24-hour urine collection, were analyzed. Macronutrient energy substitution models were used.Results:Mean estimated protein intake was 14.6 E% from DHI and 11.3 E% from urinary nitrogen. Estimated from DHI, FM increased 46 gram/year with every 1 E% protein substituted for fat (95%CI: 13, 79; P=0.006) and FFM increased 15 gram/year (1, 30; P=0.046). Results were similar in other substitution models. Estimated from urinary nitrogen, FM increased 53 gram/year with 1 E% protein substituted for other macronutrients (24, 81; p<0.0005), and FFM increased 18 gram/year (6, 31; P=0.004).Conclusion:Within a habitual range, a greater protein intake was associated with BW gain, mostly in FM. This is in contrast to the expectations based on physiological and clinical trials, and calls for a better understanding of how habitual dietary protein influences long-term energy balance, versus how greater changes in dietary proteins may influence short-term energy balance.International Journal of Obesity accepted article preview online, 20 May 2014; doi:10.1038/ijo.2014.80.

U2 - 10.1038/ijo.2014.80

DO - 10.1038/ijo.2014.80

M3 - Journal article

C2 - 24840082

VL - 39

SP - 162

EP - 168

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

IS - 1

ER -

ID: 113248789