Dietary risk factors for inflammatory bowel diseases in a high-risk population: Results from the Faroese IBD study
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Dietary risk factors for inflammatory bowel diseases in a high-risk population : Results from the Faroese IBD study. / Hammer, T; Lophaven, S Nymand; Nielsen, K Rubek; Petersen, M Skaalum; Munkholm, P; Weihe, P; Burisch, J; Lynge, E.
In: United European Gastroenterology Journal, Vol. 7, No. 7, 2019, p. 924-932.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Dietary risk factors for inflammatory bowel diseases in a high-risk population
T2 - Results from the Faroese IBD study
AU - Hammer, T
AU - Lophaven, S Nymand
AU - Nielsen, K Rubek
AU - Petersen, M Skaalum
AU - Munkholm, P
AU - Weihe, P
AU - Burisch, J
AU - Lynge, E
PY - 2019
Y1 - 2019
N2 - Background: The Faroe Islands currently have the highest recorded inflammatory bowel disease (IBD) incidence in the world.Objective: This study investigated environmental risk factors for IBD in the Faroese population.Methods: Environmental exposure data including lifestyle risk factors and neurotoxicants collected for over 30 years were retrieved from the Children's Health and the Environment in the Faroes (CHEF) cohorts including mainly mother-child pairs, with exposure data collected from pregnant mothers. For lifestyle risk factors, the incidence of IBD and ulcerative colitis (UC) was calculated as the rate ratio (RR) with 95% confidence intervals (CI) in exposed versus non-exposed persons. For neurotoxicants RR was calculated for persons with high versus low exposure.Results: Six cohorts included 5698 persons with complete follow-up data and at least one exposure, and 37 were diagnosed with IBD. For pilot whale/blubber, the RR was 1.02 (95% CI, 0.48-2.18); RR of 1.01 for fish (95% CI, 0.35-2.91); and of the pollutants studied, a statistical significantly increased risk was found for 1,1,1,-trichloro-2,2-bis-(p-chlorophenyl) ethane (p,p'-DDT); RR 3.04 (95% CI, 1.12-8.30). RRs were 1.96 (95% CI, 1.03-3.73) for smoking and 1.10 (95% CI, 0.55-2.19) for alcohol intake.Conclusion: The high IBD incidence is unlikely to be caused by special dietary habits or by environmental pollutants.
AB - Background: The Faroe Islands currently have the highest recorded inflammatory bowel disease (IBD) incidence in the world.Objective: This study investigated environmental risk factors for IBD in the Faroese population.Methods: Environmental exposure data including lifestyle risk factors and neurotoxicants collected for over 30 years were retrieved from the Children's Health and the Environment in the Faroes (CHEF) cohorts including mainly mother-child pairs, with exposure data collected from pregnant mothers. For lifestyle risk factors, the incidence of IBD and ulcerative colitis (UC) was calculated as the rate ratio (RR) with 95% confidence intervals (CI) in exposed versus non-exposed persons. For neurotoxicants RR was calculated for persons with high versus low exposure.Results: Six cohorts included 5698 persons with complete follow-up data and at least one exposure, and 37 were diagnosed with IBD. For pilot whale/blubber, the RR was 1.02 (95% CI, 0.48-2.18); RR of 1.01 for fish (95% CI, 0.35-2.91); and of the pollutants studied, a statistical significantly increased risk was found for 1,1,1,-trichloro-2,2-bis-(p-chlorophenyl) ethane (p,p'-DDT); RR 3.04 (95% CI, 1.12-8.30). RRs were 1.96 (95% CI, 1.03-3.73) for smoking and 1.10 (95% CI, 0.55-2.19) for alcohol intake.Conclusion: The high IBD incidence is unlikely to be caused by special dietary habits or by environmental pollutants.
U2 - 10.1177/2050640619852244
DO - 10.1177/2050640619852244
M3 - Journal article
C2 - 31428417
VL - 7
SP - 924
EP - 932
JO - United European Gastroenterology Journal
JF - United European Gastroenterology Journal
SN - 2050-6406
IS - 7
ER -
ID: 235859135