Different effects of anthocyanins and phenolic acids from wild blueberry (Vaccinium angustifolium) on monocytes adhesion to endothelial cells in a TNF-α stimulated proinflammatory environment

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Different effects of anthocyanins and phenolic acids from wild blueberry (Vaccinium angustifolium) on monocytes adhesion to endothelial cells in a TNF-α stimulated proinflammatory environment. / Del Bo', Cristian; Roursgaard, Martin; Porrini, Marisa; Loft, Steffen; Møller, Peter; Riso, Patrizia.

In: Molecular Nutrition & Food Research, Vol. 60, No. 11, 11.2016, p. 2355–2366.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Del Bo', C, Roursgaard, M, Porrini, M, Loft, S, Møller, P & Riso, P 2016, 'Different effects of anthocyanins and phenolic acids from wild blueberry (Vaccinium angustifolium) on monocytes adhesion to endothelial cells in a TNF-α stimulated proinflammatory environment', Molecular Nutrition & Food Research, vol. 60, no. 11, pp. 2355–2366. https://doi.org/10.1002/mnfr.201600178

APA

Del Bo', C., Roursgaard, M., Porrini, M., Loft, S., Møller, P., & Riso, P. (2016). Different effects of anthocyanins and phenolic acids from wild blueberry (Vaccinium angustifolium) on monocytes adhesion to endothelial cells in a TNF-α stimulated proinflammatory environment. Molecular Nutrition & Food Research, 60(11), 2355–2366. https://doi.org/10.1002/mnfr.201600178

Vancouver

Del Bo' C, Roursgaard M, Porrini M, Loft S, Møller P, Riso P. Different effects of anthocyanins and phenolic acids from wild blueberry (Vaccinium angustifolium) on monocytes adhesion to endothelial cells in a TNF-α stimulated proinflammatory environment. Molecular Nutrition & Food Research. 2016 Nov;60(11):2355–2366. https://doi.org/10.1002/mnfr.201600178

Author

Del Bo', Cristian ; Roursgaard, Martin ; Porrini, Marisa ; Loft, Steffen ; Møller, Peter ; Riso, Patrizia. / Different effects of anthocyanins and phenolic acids from wild blueberry (Vaccinium angustifolium) on monocytes adhesion to endothelial cells in a TNF-α stimulated proinflammatory environment. In: Molecular Nutrition & Food Research. 2016 ; Vol. 60, No. 11. pp. 2355–2366.

Bibtex

@article{5f688f40716342fb8d9fc665849909ba,
title = "Different effects of anthocyanins and phenolic acids from wild blueberry (Vaccinium angustifolium) on monocytes adhesion to endothelial cells in a TNF-α stimulated proinflammatory environment",
abstract = "Scope: Monocyte adhesion to the vascular endothelium is a crucial step in the early stagesof atherogenesis. This study aims to investigate the capacity of an anthocyanin (ACN) andphenolic acid (PA) rich fraction (RF) of a wild blueberry, single ACNs (cyanidin, malvidin,delphinidin) and related metabolites (protocatechuic, syringic, and gallic acid) to counteractmonocytes (THP-1) adhesion to human umbilical vein endothelial cells (HUVECs) in a tumornecrosis factor ␣ (TNF-␣) mediated proinflammatory environment.Methods and results: HUVECs were incubated with different concentrations (from 0.01 to 10 µg/mL) of the compounds for 24 h. Labeled monocytic THP-1 cells were added to HUVECsand their adhesion was induced by TNF-␣ (100 ng/mL). ACN-RF reduced THP-1 adhesionto HUVECs with a maximum effect at 10 µg/mL (−33{\%}). PA-RF counteracted THP-1 adhe-sion at 0.01, 0.1, and 1 µg/mL (−45, −48.7, and −27.6{\%}, respectively), but not at maximumconcentration. Supplementation with gallic acid reduced THP-1 adhesion to HUVECs with amaximum effect at 1 µg/mL (−29.9{\%}), while malvidin-3-glucoside and syringic acid increasedthe adhesion. No effect was observed for the other compounds.Conclusion: These results suggest that ACNs/PA-RF may prevent atherogenesis while theeffects of the single ACNs and metabolites are controversial and merit further exploration.",
author = "{Del Bo'}, Cristian and Martin Roursgaard and Marisa Porrini and Steffen Loft and Peter M{\o}ller and Patrizia Riso",
year = "2016",
month = "11",
doi = "10.1002/mnfr.201600178",
language = "English",
volume = "60",
pages = "2355–2366",
journal = "Molecular Nutrition & Food Research",
issn = "1613-4125",
publisher = "Wiley-VCH",
number = "11",

}

RIS

TY - JOUR

T1 - Different effects of anthocyanins and phenolic acids from wild blueberry (Vaccinium angustifolium) on monocytes adhesion to endothelial cells in a TNF-α stimulated proinflammatory environment

AU - Del Bo', Cristian

AU - Roursgaard, Martin

AU - Porrini, Marisa

AU - Loft, Steffen

AU - Møller, Peter

AU - Riso, Patrizia

PY - 2016/11

Y1 - 2016/11

N2 - Scope: Monocyte adhesion to the vascular endothelium is a crucial step in the early stagesof atherogenesis. This study aims to investigate the capacity of an anthocyanin (ACN) andphenolic acid (PA) rich fraction (RF) of a wild blueberry, single ACNs (cyanidin, malvidin,delphinidin) and related metabolites (protocatechuic, syringic, and gallic acid) to counteractmonocytes (THP-1) adhesion to human umbilical vein endothelial cells (HUVECs) in a tumornecrosis factor ␣ (TNF-␣) mediated proinflammatory environment.Methods and results: HUVECs were incubated with different concentrations (from 0.01 to 10 µg/mL) of the compounds for 24 h. Labeled monocytic THP-1 cells were added to HUVECsand their adhesion was induced by TNF-␣ (100 ng/mL). ACN-RF reduced THP-1 adhesionto HUVECs with a maximum effect at 10 µg/mL (−33%). PA-RF counteracted THP-1 adhe-sion at 0.01, 0.1, and 1 µg/mL (−45, −48.7, and −27.6%, respectively), but not at maximumconcentration. Supplementation with gallic acid reduced THP-1 adhesion to HUVECs with amaximum effect at 1 µg/mL (−29.9%), while malvidin-3-glucoside and syringic acid increasedthe adhesion. No effect was observed for the other compounds.Conclusion: These results suggest that ACNs/PA-RF may prevent atherogenesis while theeffects of the single ACNs and metabolites are controversial and merit further exploration.

AB - Scope: Monocyte adhesion to the vascular endothelium is a crucial step in the early stagesof atherogenesis. This study aims to investigate the capacity of an anthocyanin (ACN) andphenolic acid (PA) rich fraction (RF) of a wild blueberry, single ACNs (cyanidin, malvidin,delphinidin) and related metabolites (protocatechuic, syringic, and gallic acid) to counteractmonocytes (THP-1) adhesion to human umbilical vein endothelial cells (HUVECs) in a tumornecrosis factor ␣ (TNF-␣) mediated proinflammatory environment.Methods and results: HUVECs were incubated with different concentrations (from 0.01 to 10 µg/mL) of the compounds for 24 h. Labeled monocytic THP-1 cells were added to HUVECsand their adhesion was induced by TNF-␣ (100 ng/mL). ACN-RF reduced THP-1 adhesionto HUVECs with a maximum effect at 10 µg/mL (−33%). PA-RF counteracted THP-1 adhe-sion at 0.01, 0.1, and 1 µg/mL (−45, −48.7, and −27.6%, respectively), but not at maximumconcentration. Supplementation with gallic acid reduced THP-1 adhesion to HUVECs with amaximum effect at 1 µg/mL (−29.9%), while malvidin-3-glucoside and syringic acid increasedthe adhesion. No effect was observed for the other compounds.Conclusion: These results suggest that ACNs/PA-RF may prevent atherogenesis while theeffects of the single ACNs and metabolites are controversial and merit further exploration.

U2 - 10.1002/mnfr.201600178

DO - 10.1002/mnfr.201600178

M3 - Journal article

C2 - 27324255

VL - 60

SP - 2355

EP - 2366

JO - Molecular Nutrition & Food Research

JF - Molecular Nutrition & Food Research

SN - 1613-4125

IS - 11

ER -

ID: 165691099