Does type 2 diabetes confer higher relative rates of cardiovascular events in women compared with men?

Research output: Contribution to journalJournal articlepeer-review

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Does type 2 diabetes confer higher relative rates of cardiovascular events in women compared with men? / Malmborg, Morten; Schmiegelow, Michelle D. S.; Norgaard, Caroline H.; Munch, Anders; Gerds, Thomas; Schou, Morten; Kistorp, Caroline; Torp-Pedersen, Christian; Hlatky, Mark A.; Gislason, Gunnar.

In: European Heart Journal, Vol. 41, No. 13, 2020, p. 1346-1353.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Malmborg, M, Schmiegelow, MDS, Norgaard, CH, Munch, A, Gerds, T, Schou, M, Kistorp, C, Torp-Pedersen, C, Hlatky, MA & Gislason, G 2020, 'Does type 2 diabetes confer higher relative rates of cardiovascular events in women compared with men?', European Heart Journal, vol. 41, no. 13, pp. 1346-1353. https://doi.org/10.1093/eurheartj/ehz913

APA

Malmborg, M., Schmiegelow, M. D. S., Norgaard, C. H., Munch, A., Gerds, T., Schou, M., Kistorp, C., Torp-Pedersen, C., Hlatky, M. A., & Gislason, G. (2020). Does type 2 diabetes confer higher relative rates of cardiovascular events in women compared with men? European Heart Journal, 41(13), 1346-1353. https://doi.org/10.1093/eurheartj/ehz913

Vancouver

Malmborg M, Schmiegelow MDS, Norgaard CH, Munch A, Gerds T, Schou M et al. Does type 2 diabetes confer higher relative rates of cardiovascular events in women compared with men? European Heart Journal. 2020;41(13):1346-1353. https://doi.org/10.1093/eurheartj/ehz913

Author

Malmborg, Morten ; Schmiegelow, Michelle D. S. ; Norgaard, Caroline H. ; Munch, Anders ; Gerds, Thomas ; Schou, Morten ; Kistorp, Caroline ; Torp-Pedersen, Christian ; Hlatky, Mark A. ; Gislason, Gunnar. / Does type 2 diabetes confer higher relative rates of cardiovascular events in women compared with men?. In: European Heart Journal. 2020 ; Vol. 41, No. 13. pp. 1346-1353.

Bibtex

@article{dbff30c7755f42f5bd0edb43ee160411,
title = "Does type 2 diabetes confer higher relative rates of cardiovascular events in women compared with men?",
abstract = "Aims To investigate whether diabetes confers higher relative rates of cardiovascular events in women compared with men using contemporary data, and whether these sex-differences depend on age. Methods and results All Danish residents aged 40–89 years without a history major adverse cardiovascular events, including heart failure, as of 1 January 2012 until 31 December 2016 were categorized by diabetes-status and characterized by individual-level linkage of Danish nationwide administrative registers. We used Poisson regression to calculate overall and age-dependent incidence rates, incidence rate ratios, and women-to-men ratios for myocardial infarction, heart failure, ischaemic stroke, or cardiovascular death (MACE-HF). Among 218 549 (46% women) individuals with diabetes, the absolute rate of MACE-HF was higher in men than in women (24.9 vs. 19.9 per 1000 person-years). Corresponding absolute rates in men and women without diabetes were 10.1 vs. 7.0 per 1000 person-years. Comparing individuals with and without diabetes, women had higher relative rates of MACE-HF than men [2.8 (confidence interval, CI 2.9–2.9) in women vs. 2.5 (CI 2.4–2.5) in men] with a women-to-men ratio of 1.15 (CI 1.11–1.19, P < 0.001). The relative rates of MACE-HF were highest in the youngest and decreased with advancing age for both men and women, but the relative rates were higher in women across all ages, with the highest women-to-men ratio between age 50 and 60 years. Conclusion Although men have higher absolute rates of cardiovascular complications, the relative rates of cardiovascular complications associated with diabetes are higher in women than in men across all ages in the modern era.",
keywords = "Cardiovascular disease, Diabetes",
author = "Morten Malmborg and Schmiegelow, {Michelle D. S.} and Norgaard, {Caroline H.} and Anders Munch and Thomas Gerds and Morten Schou and Caroline Kistorp and Christian Torp-Pedersen and Hlatky, {Mark A.} and Gunnar Gislason",
year = "2020",
doi = "10.1093/eurheartj/ehz913",
language = "English",
volume = "41",
pages = "1346--1353",
journal = "European Heart Journal",
issn = "0195-668X",
publisher = "Oxford University Press",
number = "13",

}

RIS

TY - JOUR

T1 - Does type 2 diabetes confer higher relative rates of cardiovascular events in women compared with men?

AU - Malmborg, Morten

AU - Schmiegelow, Michelle D. S.

AU - Norgaard, Caroline H.

AU - Munch, Anders

AU - Gerds, Thomas

AU - Schou, Morten

AU - Kistorp, Caroline

AU - Torp-Pedersen, Christian

AU - Hlatky, Mark A.

AU - Gislason, Gunnar

PY - 2020

Y1 - 2020

N2 - Aims To investigate whether diabetes confers higher relative rates of cardiovascular events in women compared with men using contemporary data, and whether these sex-differences depend on age. Methods and results All Danish residents aged 40–89 years without a history major adverse cardiovascular events, including heart failure, as of 1 January 2012 until 31 December 2016 were categorized by diabetes-status and characterized by individual-level linkage of Danish nationwide administrative registers. We used Poisson regression to calculate overall and age-dependent incidence rates, incidence rate ratios, and women-to-men ratios for myocardial infarction, heart failure, ischaemic stroke, or cardiovascular death (MACE-HF). Among 218 549 (46% women) individuals with diabetes, the absolute rate of MACE-HF was higher in men than in women (24.9 vs. 19.9 per 1000 person-years). Corresponding absolute rates in men and women without diabetes were 10.1 vs. 7.0 per 1000 person-years. Comparing individuals with and without diabetes, women had higher relative rates of MACE-HF than men [2.8 (confidence interval, CI 2.9–2.9) in women vs. 2.5 (CI 2.4–2.5) in men] with a women-to-men ratio of 1.15 (CI 1.11–1.19, P < 0.001). The relative rates of MACE-HF were highest in the youngest and decreased with advancing age for both men and women, but the relative rates were higher in women across all ages, with the highest women-to-men ratio between age 50 and 60 years. Conclusion Although men have higher absolute rates of cardiovascular complications, the relative rates of cardiovascular complications associated with diabetes are higher in women than in men across all ages in the modern era.

AB - Aims To investigate whether diabetes confers higher relative rates of cardiovascular events in women compared with men using contemporary data, and whether these sex-differences depend on age. Methods and results All Danish residents aged 40–89 years without a history major adverse cardiovascular events, including heart failure, as of 1 January 2012 until 31 December 2016 were categorized by diabetes-status and characterized by individual-level linkage of Danish nationwide administrative registers. We used Poisson regression to calculate overall and age-dependent incidence rates, incidence rate ratios, and women-to-men ratios for myocardial infarction, heart failure, ischaemic stroke, or cardiovascular death (MACE-HF). Among 218 549 (46% women) individuals with diabetes, the absolute rate of MACE-HF was higher in men than in women (24.9 vs. 19.9 per 1000 person-years). Corresponding absolute rates in men and women without diabetes were 10.1 vs. 7.0 per 1000 person-years. Comparing individuals with and without diabetes, women had higher relative rates of MACE-HF than men [2.8 (confidence interval, CI 2.9–2.9) in women vs. 2.5 (CI 2.4–2.5) in men] with a women-to-men ratio of 1.15 (CI 1.11–1.19, P < 0.001). The relative rates of MACE-HF were highest in the youngest and decreased with advancing age for both men and women, but the relative rates were higher in women across all ages, with the highest women-to-men ratio between age 50 and 60 years. Conclusion Although men have higher absolute rates of cardiovascular complications, the relative rates of cardiovascular complications associated with diabetes are higher in women than in men across all ages in the modern era.

KW - Cardiovascular disease

KW - Diabetes

U2 - 10.1093/eurheartj/ehz913

DO - 10.1093/eurheartj/ehz913

M3 - Journal article

C2 - 31860067

VL - 41

SP - 1346

EP - 1353

JO - European Heart Journal

JF - European Heart Journal

SN - 0195-668X

IS - 13

ER -

ID: 239561556