Does vitamin C deficiency affect cognitive development and function?

Research output: Contribution to journal › Journal article › Research › peer-review

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Does vitamin C deficiency affect cognitive development and function? / Hansen, Stine Normann; Tveden-Nyborg, Pernille; Lykkesfeldt, Jens.

In: Nutrients, Vol. 6, No. 9, 2014, p. 3818-3846.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hansen, SN, Tveden-Nyborg, P & Lykkesfeldt, J 2014, 'Does vitamin C deficiency affect cognitive development and function?', Nutrients, vol. 6, no. 9, pp. 3818-3846. https://doi.org/10.3390/nu6093818

APA

Hansen, S. N., Tveden-Nyborg, P., & Lykkesfeldt, J. (2014). Does vitamin C deficiency affect cognitive development and function? Nutrients, 6(9), 3818-3846. https://doi.org/10.3390/nu6093818

Vancouver

Hansen SN, Tveden-Nyborg P, Lykkesfeldt J. Does vitamin C deficiency affect cognitive development and function? Nutrients. 2014;6(9):3818-3846. https://doi.org/10.3390/nu6093818

Author

Hansen, Stine Normann ; Tveden-Nyborg, Pernille ; Lykkesfeldt, Jens. / Does vitamin C deficiency affect cognitive development and function?. In: Nutrients. 2014 ; Vol. 6, No. 9. pp. 3818-3846.

Bibtex

@article{3024cef310794051ae470eabb4267853,
title = "Does vitamin C deficiency affect cognitive development and function?",
abstract = "Vitamin C is a pivotal antioxidant in the brain and has been reported to have numerous functions, including reactive oxygen species scavenging, neuromodulation, and involvement in angiogenesis. Absence of vitamin C in the brain has been shown to be detrimental to survival in newborn SVCT2(-/-) mice and perinatal deficiency have shown to reduce hippocampal volume and neuron number and cause decreased spatial cognition in guinea pigs, suggesting that maternal vitamin C deficiency could have severe consequences for the offspring. Furthermore, vitamin C deficiency has been proposed to play a role in age-related cognitive decline and in stroke risk and severity. The present review discusses the available literature on effects of vitamin C deficiency on the developing and aging brain with particular focus on in vivo experimentation and clinical studies.",
keywords = "Faculty of Health and Medical Sciences, vitamin C, cognition, oxidative stress, ROS, aging, development, stroke",
author = "Hansen, {Stine Normann} and Pernille Tveden-Nyborg and Jens Lykkesfeldt",
year = "2014",
doi = "10.3390/nu6093818",
language = "English",
volume = "6",
pages = "3818--3846",
journal = "Nutrients",
issn = "2072-6643",
publisher = "M D P I AG",
number = "9",

}

RIS

TY - JOUR

T1 - Does vitamin C deficiency affect cognitive development and function?

AU - Hansen, Stine Normann

AU - Tveden-Nyborg, Pernille

AU - Lykkesfeldt, Jens

PY - 2014

Y1 - 2014

N2 - Vitamin C is a pivotal antioxidant in the brain and has been reported to have numerous functions, including reactive oxygen species scavenging, neuromodulation, and involvement in angiogenesis. Absence of vitamin C in the brain has been shown to be detrimental to survival in newborn SVCT2(-/-) mice and perinatal deficiency have shown to reduce hippocampal volume and neuron number and cause decreased spatial cognition in guinea pigs, suggesting that maternal vitamin C deficiency could have severe consequences for the offspring. Furthermore, vitamin C deficiency has been proposed to play a role in age-related cognitive decline and in stroke risk and severity. The present review discusses the available literature on effects of vitamin C deficiency on the developing and aging brain with particular focus on in vivo experimentation and clinical studies.

AB - Vitamin C is a pivotal antioxidant in the brain and has been reported to have numerous functions, including reactive oxygen species scavenging, neuromodulation, and involvement in angiogenesis. Absence of vitamin C in the brain has been shown to be detrimental to survival in newborn SVCT2(-/-) mice and perinatal deficiency have shown to reduce hippocampal volume and neuron number and cause decreased spatial cognition in guinea pigs, suggesting that maternal vitamin C deficiency could have severe consequences for the offspring. Furthermore, vitamin C deficiency has been proposed to play a role in age-related cognitive decline and in stroke risk and severity. The present review discusses the available literature on effects of vitamin C deficiency on the developing and aging brain with particular focus on in vivo experimentation and clinical studies.

KW - Faculty of Health and Medical Sciences

KW - vitamin C

KW - cognition

KW - oxidative stress

KW - ROS

KW - aging

KW - development

KW - stroke

U2 - 10.3390/nu6093818

DO - 10.3390/nu6093818

M3 - Journal article

C2 - 25244370

VL - 6

SP - 3818

EP - 3846

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 9

ER -

ID: 124426815