Does vitamin C deficiency promote fatty liver disease development?

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Does vitamin C deficiency promote fatty liver disease development? / Ipsen, David Højland; Tveden-Nyborg, Pernille; Lykkesfeldt, Jens.

In: Nutrients, Vol. 6, No. 12, 2014, p. 5473-5499.

Research output: Contribution to journalReviewResearchpeer-review

Harvard

Ipsen, DH, Tveden-Nyborg, P & Lykkesfeldt, J 2014, 'Does vitamin C deficiency promote fatty liver disease development?', Nutrients, vol. 6, no. 12, pp. 5473-5499. https://doi.org/10.3390/nu6125473

APA

Ipsen, D. H., Tveden-Nyborg, P., & Lykkesfeldt, J. (2014). Does vitamin C deficiency promote fatty liver disease development? Nutrients, 6(12), 5473-5499. https://doi.org/10.3390/nu6125473

Vancouver

Ipsen DH, Tveden-Nyborg P, Lykkesfeldt J. Does vitamin C deficiency promote fatty liver disease development? Nutrients. 2014;6(12):5473-5499. https://doi.org/10.3390/nu6125473

Author

Ipsen, David Højland ; Tveden-Nyborg, Pernille ; Lykkesfeldt, Jens. / Does vitamin C deficiency promote fatty liver disease development?. In: Nutrients. 2014 ; Vol. 6, No. 12. pp. 5473-5499.

Bibtex

@article{0eec2b011f514fb785c8298555a55a95,
title = "Does vitamin C deficiency promote fatty liver disease development?",
abstract = "Obesity and the subsequent reprogramming of the white adipose tissue are linked to human disease-complexes including metabolic syndrome and concurrent non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). The dietary imposed dyslipidemia promotes redox imbalance by the generation of excess levels of reactive oxygen species and induces adipocyte dysfunction and reprogramming, leading to a low grade systemic inflammation and ectopic lipid deposition, e.g., in the liver, hereby promoting a vicious circle in which dietary factors initiate a metabolic change that further exacerbates the negative consequences of an adverse life-style. Large epidemiological studies and findings from controlled in vivo animal studies have provided evidence supporting an association between poor vitamin C (VitC) status and propagation of life-style associated diseases. In addition, overweight per se has been shown to result in reduced plasma VitC, and the distribution of body fat in obesity has been shown to have an inverse relationship with VitC plasma levels. Recently, a number of epidemiological studies have indicated a VitC intake below the recommended daily allowance (RDA) in NAFLD-patients, suggesting an association between dietary habits, disease and VitC deficiency. In the general population, VitC deficiency (defined as a plasma concentration below 23 μM) affects around 10{\%} of adults, however, this prevalence is increased by an adverse life-style, deficiency potentially playing a broader role in disease progression in specific subgroups. This review discusses the currently available data from human surveys and experimental models in search of a putative role of VitC deficiency in the development of NAFLD and NASH.",
keywords = "Faculty of Health and Medical Sciences, antioxidants, obesity, oxidative stress, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, reactive oxygen species, vitamin C, vitamin C deficiency",
author = "Ipsen, {David H{\o}jland} and Pernille Tveden-Nyborg and Jens Lykkesfeldt",
year = "2014",
doi = "10.3390/nu6125473",
language = "English",
volume = "6",
pages = "5473--5499",
journal = "Nutrients",
issn = "2072-6643",
publisher = "M D P I AG",
number = "12",

}

RIS

TY - JOUR

T1 - Does vitamin C deficiency promote fatty liver disease development?

AU - Ipsen, David Højland

AU - Tveden-Nyborg, Pernille

AU - Lykkesfeldt, Jens

PY - 2014

Y1 - 2014

N2 - Obesity and the subsequent reprogramming of the white adipose tissue are linked to human disease-complexes including metabolic syndrome and concurrent non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). The dietary imposed dyslipidemia promotes redox imbalance by the generation of excess levels of reactive oxygen species and induces adipocyte dysfunction and reprogramming, leading to a low grade systemic inflammation and ectopic lipid deposition, e.g., in the liver, hereby promoting a vicious circle in which dietary factors initiate a metabolic change that further exacerbates the negative consequences of an adverse life-style. Large epidemiological studies and findings from controlled in vivo animal studies have provided evidence supporting an association between poor vitamin C (VitC) status and propagation of life-style associated diseases. In addition, overweight per se has been shown to result in reduced plasma VitC, and the distribution of body fat in obesity has been shown to have an inverse relationship with VitC plasma levels. Recently, a number of epidemiological studies have indicated a VitC intake below the recommended daily allowance (RDA) in NAFLD-patients, suggesting an association between dietary habits, disease and VitC deficiency. In the general population, VitC deficiency (defined as a plasma concentration below 23 μM) affects around 10% of adults, however, this prevalence is increased by an adverse life-style, deficiency potentially playing a broader role in disease progression in specific subgroups. This review discusses the currently available data from human surveys and experimental models in search of a putative role of VitC deficiency in the development of NAFLD and NASH.

AB - Obesity and the subsequent reprogramming of the white adipose tissue are linked to human disease-complexes including metabolic syndrome and concurrent non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). The dietary imposed dyslipidemia promotes redox imbalance by the generation of excess levels of reactive oxygen species and induces adipocyte dysfunction and reprogramming, leading to a low grade systemic inflammation and ectopic lipid deposition, e.g., in the liver, hereby promoting a vicious circle in which dietary factors initiate a metabolic change that further exacerbates the negative consequences of an adverse life-style. Large epidemiological studies and findings from controlled in vivo animal studies have provided evidence supporting an association between poor vitamin C (VitC) status and propagation of life-style associated diseases. In addition, overweight per se has been shown to result in reduced plasma VitC, and the distribution of body fat in obesity has been shown to have an inverse relationship with VitC plasma levels. Recently, a number of epidemiological studies have indicated a VitC intake below the recommended daily allowance (RDA) in NAFLD-patients, suggesting an association between dietary habits, disease and VitC deficiency. In the general population, VitC deficiency (defined as a plasma concentration below 23 μM) affects around 10% of adults, however, this prevalence is increased by an adverse life-style, deficiency potentially playing a broader role in disease progression in specific subgroups. This review discusses the currently available data from human surveys and experimental models in search of a putative role of VitC deficiency in the development of NAFLD and NASH.

KW - Faculty of Health and Medical Sciences

KW - antioxidants

KW - obesity

KW - oxidative stress

KW - non-alcoholic fatty liver disease

KW - non-alcoholic steatohepatitis

KW - reactive oxygen species

KW - vitamin C

KW - vitamin C deficiency

U2 - 10.3390/nu6125473

DO - 10.3390/nu6125473

M3 - Review

C2 - 25533004

VL - 6

SP - 5473

EP - 5499

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 12

ER -

ID: 131880587