Eccentric rehabilitation exercise increases peritendinous type I collagen synthesis in humans with Achilles tendinosis

Research output: Contribution to journalJournal articlepeer-review

Standard

Eccentric rehabilitation exercise increases peritendinous type I collagen synthesis in humans with Achilles tendinosis. / Langberg, Henning; Ellingsgaard, H; Madsen, T; Jansson, J; Magnusson, S P; Aagaard, P; Kjaer, M.

In: Scandinavian Journal of Medicine & Science in Sports, Vol. 17, No. 1, 2007, p. 61-6.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Langberg, H, Ellingsgaard, H, Madsen, T, Jansson, J, Magnusson, SP, Aagaard, P & Kjaer, M 2007, 'Eccentric rehabilitation exercise increases peritendinous type I collagen synthesis in humans with Achilles tendinosis', Scandinavian Journal of Medicine & Science in Sports, vol. 17, no. 1, pp. 61-6. https://doi.org/10.1111/j.1600-0838.2006.00522.x

APA

Langberg, H., Ellingsgaard, H., Madsen, T., Jansson, J., Magnusson, S. P., Aagaard, P., & Kjaer, M. (2007). Eccentric rehabilitation exercise increases peritendinous type I collagen synthesis in humans with Achilles tendinosis. Scandinavian Journal of Medicine & Science in Sports, 17(1), 61-6. https://doi.org/10.1111/j.1600-0838.2006.00522.x

Vancouver

Langberg H, Ellingsgaard H, Madsen T, Jansson J, Magnusson SP, Aagaard P et al. Eccentric rehabilitation exercise increases peritendinous type I collagen synthesis in humans with Achilles tendinosis. Scandinavian Journal of Medicine & Science in Sports. 2007;17(1):61-6. https://doi.org/10.1111/j.1600-0838.2006.00522.x

Author

Langberg, Henning ; Ellingsgaard, H ; Madsen, T ; Jansson, J ; Magnusson, S P ; Aagaard, P ; Kjaer, M. / Eccentric rehabilitation exercise increases peritendinous type I collagen synthesis in humans with Achilles tendinosis. In: Scandinavian Journal of Medicine & Science in Sports. 2007 ; Vol. 17, No. 1. pp. 61-6.

Bibtex

@article{e38a15911d6a4fafbd9cb45b23252a8b,
title = "Eccentric rehabilitation exercise increases peritendinous type I collagen synthesis in humans with Achilles tendinosis",
abstract = "It has been shown that 12 weeks of eccentric heavy resistance training can reduce pain in runners suffering from chronic Achilles tendinosis, but the mechanism behind the effectiveness of this treatment is unknown. The present study investigates the local effect of an eccentric training regime on elite soccer players suffering from chronic Achilles tendinosis on the turnover of the peritendinous connective tissue. Twelve elite male soccer players, of whom six suffered from unilateral tendinosis and six were healthy controls, participated in this study. All participants performed 12 weeks of heavy-resistance eccentric training apart from their regular training and soccer activity. Before and after the training period the tissue concentration of indicators of collagen turnover was measured by the use of the microdialysis technique. After training, collagen synthesis was increased in the initially injured tendon (n=6; carboxyterminal propeptide of type I collagen (PICP): pre 3.9+/-2.5 microg/L to post 19.7+/-5.4 microg/L, P0.05). Collagen degradation, measured as carboxyterminal telopeptide region of type I collagen (ICTP), was not affected by training neither in the injured nor in the healthy tendons. The clinical effect of the 12 weeks of eccentric training was determined by using a standardized loading procedure of the Achilles tendons showing a decrease in pain in all the chronic injured tendons (VAS before 44+/-9, after 13+/-9; P",
keywords = "Achilles Tendon, Adult, Case-Control Studies, Chronic Disease, Collagen Type I, Exercise Therapy, Humans, Male, Microdialysis, Pain Measurement, Soccer, Statistics, Nonparametric, Tendinopathy, Treatment Outcome",
author = "Henning Langberg and H Ellingsgaard and T Madsen and J Jansson and Magnusson, {S P} and P Aagaard and M Kjaer",
year = "2007",
doi = "10.1111/j.1600-0838.2006.00522.x",
language = "English",
volume = "17",
pages = "61--6",
journal = "Scandinavian Journal of Medicine & Science in Sports",
issn = "0905-7188",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - Eccentric rehabilitation exercise increases peritendinous type I collagen synthesis in humans with Achilles tendinosis

AU - Langberg, Henning

AU - Ellingsgaard, H

AU - Madsen, T

AU - Jansson, J

AU - Magnusson, S P

AU - Aagaard, P

AU - Kjaer, M

PY - 2007

Y1 - 2007

N2 - It has been shown that 12 weeks of eccentric heavy resistance training can reduce pain in runners suffering from chronic Achilles tendinosis, but the mechanism behind the effectiveness of this treatment is unknown. The present study investigates the local effect of an eccentric training regime on elite soccer players suffering from chronic Achilles tendinosis on the turnover of the peritendinous connective tissue. Twelve elite male soccer players, of whom six suffered from unilateral tendinosis and six were healthy controls, participated in this study. All participants performed 12 weeks of heavy-resistance eccentric training apart from their regular training and soccer activity. Before and after the training period the tissue concentration of indicators of collagen turnover was measured by the use of the microdialysis technique. After training, collagen synthesis was increased in the initially injured tendon (n=6; carboxyterminal propeptide of type I collagen (PICP): pre 3.9+/-2.5 microg/L to post 19.7+/-5.4 microg/L, P0.05). Collagen degradation, measured as carboxyterminal telopeptide region of type I collagen (ICTP), was not affected by training neither in the injured nor in the healthy tendons. The clinical effect of the 12 weeks of eccentric training was determined by using a standardized loading procedure of the Achilles tendons showing a decrease in pain in all the chronic injured tendons (VAS before 44+/-9, after 13+/-9; P

AB - It has been shown that 12 weeks of eccentric heavy resistance training can reduce pain in runners suffering from chronic Achilles tendinosis, but the mechanism behind the effectiveness of this treatment is unknown. The present study investigates the local effect of an eccentric training regime on elite soccer players suffering from chronic Achilles tendinosis on the turnover of the peritendinous connective tissue. Twelve elite male soccer players, of whom six suffered from unilateral tendinosis and six were healthy controls, participated in this study. All participants performed 12 weeks of heavy-resistance eccentric training apart from their regular training and soccer activity. Before and after the training period the tissue concentration of indicators of collagen turnover was measured by the use of the microdialysis technique. After training, collagen synthesis was increased in the initially injured tendon (n=6; carboxyterminal propeptide of type I collagen (PICP): pre 3.9+/-2.5 microg/L to post 19.7+/-5.4 microg/L, P0.05). Collagen degradation, measured as carboxyterminal telopeptide region of type I collagen (ICTP), was not affected by training neither in the injured nor in the healthy tendons. The clinical effect of the 12 weeks of eccentric training was determined by using a standardized loading procedure of the Achilles tendons showing a decrease in pain in all the chronic injured tendons (VAS before 44+/-9, after 13+/-9; P

KW - Achilles Tendon

KW - Adult

KW - Case-Control Studies

KW - Chronic Disease

KW - Collagen Type I

KW - Exercise Therapy

KW - Humans

KW - Male

KW - Microdialysis

KW - Pain Measurement

KW - Soccer

KW - Statistics, Nonparametric

KW - Tendinopathy

KW - Treatment Outcome

U2 - 10.1111/j.1600-0838.2006.00522.x

DO - 10.1111/j.1600-0838.2006.00522.x

M3 - Journal article

C2 - 16787448

VL - 17

SP - 61

EP - 66

JO - Scandinavian Journal of Medicine & Science in Sports

JF - Scandinavian Journal of Medicine & Science in Sports

SN - 0905-7188

IS - 1

ER -

ID: 38366604