Eccentric rehabilitation exercise increases peritendinous type I collagen synthesis in humans with Achilles tendinosis
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Eccentric rehabilitation exercise increases peritendinous type I collagen synthesis in humans with Achilles tendinosis. / Langberg, Henning; Ellingsgaard, H; Madsen, T; Jansson, J; Magnusson, S P; Aagaard, P; Kjaer, M.
In: Scandinavian Journal of Medicine & Science in Sports, Vol. 17, No. 1, 2007, p. 61-6.Research output: Contribution to journal › Journal article › peer-review
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T1 - Eccentric rehabilitation exercise increases peritendinous type I collagen synthesis in humans with Achilles tendinosis
AU - Langberg, Henning
AU - Ellingsgaard, H
AU - Madsen, T
AU - Jansson, J
AU - Magnusson, S P
AU - Aagaard, P
AU - Kjaer, M
PY - 2007
Y1 - 2007
N2 - It has been shown that 12 weeks of eccentric heavy resistance training can reduce pain in runners suffering from chronic Achilles tendinosis, but the mechanism behind the effectiveness of this treatment is unknown. The present study investigates the local effect of an eccentric training regime on elite soccer players suffering from chronic Achilles tendinosis on the turnover of the peritendinous connective tissue. Twelve elite male soccer players, of whom six suffered from unilateral tendinosis and six were healthy controls, participated in this study. All participants performed 12 weeks of heavy-resistance eccentric training apart from their regular training and soccer activity. Before and after the training period the tissue concentration of indicators of collagen turnover was measured by the use of the microdialysis technique. After training, collagen synthesis was increased in the initially injured tendon (n=6; carboxyterminal propeptide of type I collagen (PICP): pre 3.9+/-2.5 microg/L to post 19.7+/-5.4 microg/L, P0.05). Collagen degradation, measured as carboxyterminal telopeptide region of type I collagen (ICTP), was not affected by training neither in the injured nor in the healthy tendons. The clinical effect of the 12 weeks of eccentric training was determined by using a standardized loading procedure of the Achilles tendons showing a decrease in pain in all the chronic injured tendons (VAS before 44+/-9, after 13+/-9; P
AB - It has been shown that 12 weeks of eccentric heavy resistance training can reduce pain in runners suffering from chronic Achilles tendinosis, but the mechanism behind the effectiveness of this treatment is unknown. The present study investigates the local effect of an eccentric training regime on elite soccer players suffering from chronic Achilles tendinosis on the turnover of the peritendinous connective tissue. Twelve elite male soccer players, of whom six suffered from unilateral tendinosis and six were healthy controls, participated in this study. All participants performed 12 weeks of heavy-resistance eccentric training apart from their regular training and soccer activity. Before and after the training period the tissue concentration of indicators of collagen turnover was measured by the use of the microdialysis technique. After training, collagen synthesis was increased in the initially injured tendon (n=6; carboxyterminal propeptide of type I collagen (PICP): pre 3.9+/-2.5 microg/L to post 19.7+/-5.4 microg/L, P0.05). Collagen degradation, measured as carboxyterminal telopeptide region of type I collagen (ICTP), was not affected by training neither in the injured nor in the healthy tendons. The clinical effect of the 12 weeks of eccentric training was determined by using a standardized loading procedure of the Achilles tendons showing a decrease in pain in all the chronic injured tendons (VAS before 44+/-9, after 13+/-9; P
KW - Achilles Tendon
KW - Adult
KW - Case-Control Studies
KW - Chronic Disease
KW - Collagen Type I
KW - Exercise Therapy
KW - Humans
KW - Male
KW - Microdialysis
KW - Pain Measurement
KW - Soccer
KW - Statistics, Nonparametric
KW - Tendinopathy
KW - Treatment Outcome
U2 - 10.1111/j.1600-0838.2006.00522.x
DO - 10.1111/j.1600-0838.2006.00522.x
M3 - Journal article
C2 - 16787448
VL - 17
SP - 61
EP - 66
JO - Scandinavian Journal of Medicine & Science in Sports
JF - Scandinavian Journal of Medicine & Science in Sports
SN - 0905-7188
IS - 1
ER -
ID: 38366604