Effect of the cannabinoid receptor-1 antagonist rimonabant on lipolysis in rats

Research output: Contribution to journalJournal articlepeer-review

Standard

Effect of the cannabinoid receptor-1 antagonist rimonabant on lipolysis in rats. / Mølhøj, Signe; Hansen, Harald S; Schweiger, Martina; Zimmermann, Robert; Johansen, Thue; Malmlöf, Kjell.

In: European Journal of Pharmacology, Vol. 646, No. 1-3, 2010, p. 38-45.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Mølhøj, S, Hansen, HS, Schweiger, M, Zimmermann, R, Johansen, T & Malmlöf, K 2010, 'Effect of the cannabinoid receptor-1 antagonist rimonabant on lipolysis in rats', European Journal of Pharmacology, vol. 646, no. 1-3, pp. 38-45. https://doi.org/10.1016/j.ejphar.2010.08.006

APA

Mølhøj, S., Hansen, H. S., Schweiger, M., Zimmermann, R., Johansen, T., & Malmlöf, K. (2010). Effect of the cannabinoid receptor-1 antagonist rimonabant on lipolysis in rats. European Journal of Pharmacology, 646(1-3), 38-45. https://doi.org/10.1016/j.ejphar.2010.08.006

Vancouver

Mølhøj S, Hansen HS, Schweiger M, Zimmermann R, Johansen T, Malmlöf K. Effect of the cannabinoid receptor-1 antagonist rimonabant on lipolysis in rats. European Journal of Pharmacology. 2010;646(1-3):38-45. https://doi.org/10.1016/j.ejphar.2010.08.006

Author

Mølhøj, Signe ; Hansen, Harald S ; Schweiger, Martina ; Zimmermann, Robert ; Johansen, Thue ; Malmlöf, Kjell. / Effect of the cannabinoid receptor-1 antagonist rimonabant on lipolysis in rats. In: European Journal of Pharmacology. 2010 ; Vol. 646, No. 1-3. pp. 38-45.

Bibtex

@article{512b9330f89511dfb6d2000ea68e967b,
title = "Effect of the cannabinoid receptor-1 antagonist rimonabant on lipolysis in rats",
abstract = "The cannabinoid receptor 1 antagonist, rimonabant, reduces food intake and body weight, but contradictory findings have been reported as to whether the weight-reducing effect is fully accounted for by the reduced food intake or if rimonabant also mediates a lipolytic effect. In the present study, the effect on weight loss was studied in diet-induced obese rats after 3 days and 3 weeks of exposure to rimonabant, respectively. Induction of lipolysis was examined following acute administration and following 3 weeks of repeated dosing. Rimonabant-treated rats lost significantly more weight than their food-restricted controls. This effect was most pronounced in the beginning of the treatment period. No increase in lipolytic activity was found after 3 weeks of repeated dosing as measured by microdialysis in adipose tissue whereas acute administration of 10mg/kg produced a significant increase in microdialysate levels of glycerol illustrating an acute stimulation of lipolysis. No equivalent increase in glycerol was, however, observed in vitro following incubation of isolated rat adipocytes with rimonabant. This finding excludes a direct lipolytic action of rimonabant on tissue level. Instead, administration of 10mg/kg produced a significant increase in noradrenaline excretion in diet-induced obese rats, suggesting an increase in sympathoadrenal activity. In conclusion, the present study suggests an acute lipolytic effect of rimonabant mediated through activation of the sympathoadrenal system.",
keywords = "Former Faculty of Pharmaceutical Sciences",
author = "Signe M{\o}lh{\o}j and Hansen, {Harald S} and Martina Schweiger and Robert Zimmermann and Thue Johansen and Kjell Malml{\"o}f",
note = "Copyright {\textcopyright} 2010 Elsevier B.V. All rights reserved.",
year = "2010",
doi = "10.1016/j.ejphar.2010.08.006",
language = "English",
volume = "646",
pages = "38--45",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier",
number = "1-3",

}

RIS

TY - JOUR

T1 - Effect of the cannabinoid receptor-1 antagonist rimonabant on lipolysis in rats

AU - Mølhøj, Signe

AU - Hansen, Harald S

AU - Schweiger, Martina

AU - Zimmermann, Robert

AU - Johansen, Thue

AU - Malmlöf, Kjell

N1 - Copyright © 2010 Elsevier B.V. All rights reserved.

PY - 2010

Y1 - 2010

N2 - The cannabinoid receptor 1 antagonist, rimonabant, reduces food intake and body weight, but contradictory findings have been reported as to whether the weight-reducing effect is fully accounted for by the reduced food intake or if rimonabant also mediates a lipolytic effect. In the present study, the effect on weight loss was studied in diet-induced obese rats after 3 days and 3 weeks of exposure to rimonabant, respectively. Induction of lipolysis was examined following acute administration and following 3 weeks of repeated dosing. Rimonabant-treated rats lost significantly more weight than their food-restricted controls. This effect was most pronounced in the beginning of the treatment period. No increase in lipolytic activity was found after 3 weeks of repeated dosing as measured by microdialysis in adipose tissue whereas acute administration of 10mg/kg produced a significant increase in microdialysate levels of glycerol illustrating an acute stimulation of lipolysis. No equivalent increase in glycerol was, however, observed in vitro following incubation of isolated rat adipocytes with rimonabant. This finding excludes a direct lipolytic action of rimonabant on tissue level. Instead, administration of 10mg/kg produced a significant increase in noradrenaline excretion in diet-induced obese rats, suggesting an increase in sympathoadrenal activity. In conclusion, the present study suggests an acute lipolytic effect of rimonabant mediated through activation of the sympathoadrenal system.

AB - The cannabinoid receptor 1 antagonist, rimonabant, reduces food intake and body weight, but contradictory findings have been reported as to whether the weight-reducing effect is fully accounted for by the reduced food intake or if rimonabant also mediates a lipolytic effect. In the present study, the effect on weight loss was studied in diet-induced obese rats after 3 days and 3 weeks of exposure to rimonabant, respectively. Induction of lipolysis was examined following acute administration and following 3 weeks of repeated dosing. Rimonabant-treated rats lost significantly more weight than their food-restricted controls. This effect was most pronounced in the beginning of the treatment period. No increase in lipolytic activity was found after 3 weeks of repeated dosing as measured by microdialysis in adipose tissue whereas acute administration of 10mg/kg produced a significant increase in microdialysate levels of glycerol illustrating an acute stimulation of lipolysis. No equivalent increase in glycerol was, however, observed in vitro following incubation of isolated rat adipocytes with rimonabant. This finding excludes a direct lipolytic action of rimonabant on tissue level. Instead, administration of 10mg/kg produced a significant increase in noradrenaline excretion in diet-induced obese rats, suggesting an increase in sympathoadrenal activity. In conclusion, the present study suggests an acute lipolytic effect of rimonabant mediated through activation of the sympathoadrenal system.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1016/j.ejphar.2010.08.006

DO - 10.1016/j.ejphar.2010.08.006

M3 - Journal article

C2 - 20727879

VL - 646

SP - 38

EP - 45

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 1-3

ER -

ID: 23372364