Effects of brown seaweeds on postprandial glucose, insulin and appetite in humans - A randomized, 3-way, blinded, cross-over meal study

Research output: Contribution to journalJournal articlepeer-review

Standard

Effects of brown seaweeds on postprandial glucose, insulin and appetite in humans - A randomized, 3-way, blinded, cross-over meal study. / Zaharudin, Nazikussabah Binti; Tullin, Mikkel; Pekmez, Ceyda Tugba; Sloth, Jens J; Rasmussen, Rie R; Dragsted, Lars Ove.

In: Clinical Nutrition, Vol. 40, No. 3, 2021, p. 830-838.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Zaharudin, NB, Tullin, M, Pekmez, CT, Sloth, JJ, Rasmussen, RR & Dragsted, LO 2021, 'Effects of brown seaweeds on postprandial glucose, insulin and appetite in humans - A randomized, 3-way, blinded, cross-over meal study', Clinical Nutrition, vol. 40, no. 3, pp. 830-838. https://doi.org/10.1016/j.clnu.2020.08.027

APA

Zaharudin, N. B., Tullin, M., Pekmez, C. T., Sloth, J. J., Rasmussen, R. R., & Dragsted, L. O. (2021). Effects of brown seaweeds on postprandial glucose, insulin and appetite in humans - A randomized, 3-way, blinded, cross-over meal study. Clinical Nutrition, 40(3), 830-838. https://doi.org/10.1016/j.clnu.2020.08.027

Vancouver

Zaharudin NB, Tullin M, Pekmez CT, Sloth JJ, Rasmussen RR, Dragsted LO. Effects of brown seaweeds on postprandial glucose, insulin and appetite in humans - A randomized, 3-way, blinded, cross-over meal study. Clinical Nutrition. 2021;40(3):830-838. https://doi.org/10.1016/j.clnu.2020.08.027

Author

Zaharudin, Nazikussabah Binti ; Tullin, Mikkel ; Pekmez, Ceyda Tugba ; Sloth, Jens J ; Rasmussen, Rie R ; Dragsted, Lars Ove. / Effects of brown seaweeds on postprandial glucose, insulin and appetite in humans - A randomized, 3-way, blinded, cross-over meal study. In: Clinical Nutrition. 2021 ; Vol. 40, No. 3. pp. 830-838.

Bibtex

@article{0a1563fffff84d3f920fc8b9d2406a6b,
title = "Effects of brown seaweeds on postprandial glucose, insulin and appetite in humans - A randomized, 3-way, blinded, cross-over meal study",
abstract = "Background & aims: Seaweed including brown seaweeds with rich bioactive components may be efficacious for a glycaemic management strategy and appetite control. We investigated the effects of two brown edible seaweeds, Laminaria digitata (LD) and Undaria pinnatifida (UP), on postprandial glucose metabolism and appetite following a starch load in a human meal study.Methods: Twenty healthy subjects were enrolled in a randomized, 3-way, blinded cross-over trial. The study was registered under ClinicalTrials.gov Identifier no. NCT00123456. At each test day, the subjects received one of three meals comprising 30 g of starch with 5 g of LD or UP or an energy-adjusted control meal containing pea protein. Fasting and postprandial blood glucose, insulin, C-peptide and glucagon-like peptide-1 (GLP-1) concentrations were measured. Subjective appetite sensations were scored using visual analogue scales (VAS).Results: Linear mixed model (LMM) analysis showed a lower blood glucose, insulin and C-peptide response following the intake of LD and UP, after correction for body weight. Participants weighing ≤ 63 kg had a reduced glucose response compared to control meal between 40 and 90 min both following LD and UP meals. Furthermore, LMM analysis for C-peptide showed a significantly lower response after intake of LD. Compared to the control meal, GLP-1 response was higher after the LD meal, both before and after the body weight adjustment. The VAS scores showed a decreased appetite sensation after intake of the seaweeds. Ad-libitum food intake was not different three hours after the seaweed meals compared to control.Conclusions: Concomitant ingestion of brown seaweeds may help improving postprandial glycaemic and appetite control in healthy and normal weight adults, depending on the dose per body weight.Clinical trial registry number: Clinicaltrials.gov (ID# NCT02608372).",
keywords = "Faculty of Science, Bioactive foods, Glycaemic response, Satiety, Resistant dietary fibers, Starch-degrading enzymes, Alpha-glucosidase",
author = "Zaharudin, {Nazikussabah Binti} and Mikkel Tullin and Pekmez, {Ceyda Tugba} and Sloth, {Jens J} and Rasmussen, {Rie R} and Dragsted, {Lars Ove}",
note = "CURIS 2021 NEXS 096",
year = "2021",
doi = "10.1016/j.clnu.2020.08.027",
language = "English",
volume = "40",
pages = "830--838",
journal = "Clinical Nutrition",
issn = "0261-5614",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Effects of brown seaweeds on postprandial glucose, insulin and appetite in humans - A randomized, 3-way, blinded, cross-over meal study

AU - Zaharudin, Nazikussabah Binti

AU - Tullin, Mikkel

AU - Pekmez, Ceyda Tugba

AU - Sloth, Jens J

AU - Rasmussen, Rie R

AU - Dragsted, Lars Ove

N1 - CURIS 2021 NEXS 096

PY - 2021

Y1 - 2021

N2 - Background & aims: Seaweed including brown seaweeds with rich bioactive components may be efficacious for a glycaemic management strategy and appetite control. We investigated the effects of two brown edible seaweeds, Laminaria digitata (LD) and Undaria pinnatifida (UP), on postprandial glucose metabolism and appetite following a starch load in a human meal study.Methods: Twenty healthy subjects were enrolled in a randomized, 3-way, blinded cross-over trial. The study was registered under ClinicalTrials.gov Identifier no. NCT00123456. At each test day, the subjects received one of three meals comprising 30 g of starch with 5 g of LD or UP or an energy-adjusted control meal containing pea protein. Fasting and postprandial blood glucose, insulin, C-peptide and glucagon-like peptide-1 (GLP-1) concentrations were measured. Subjective appetite sensations were scored using visual analogue scales (VAS).Results: Linear mixed model (LMM) analysis showed a lower blood glucose, insulin and C-peptide response following the intake of LD and UP, after correction for body weight. Participants weighing ≤ 63 kg had a reduced glucose response compared to control meal between 40 and 90 min both following LD and UP meals. Furthermore, LMM analysis for C-peptide showed a significantly lower response after intake of LD. Compared to the control meal, GLP-1 response was higher after the LD meal, both before and after the body weight adjustment. The VAS scores showed a decreased appetite sensation after intake of the seaweeds. Ad-libitum food intake was not different three hours after the seaweed meals compared to control.Conclusions: Concomitant ingestion of brown seaweeds may help improving postprandial glycaemic and appetite control in healthy and normal weight adults, depending on the dose per body weight.Clinical trial registry number: Clinicaltrials.gov (ID# NCT02608372).

AB - Background & aims: Seaweed including brown seaweeds with rich bioactive components may be efficacious for a glycaemic management strategy and appetite control. We investigated the effects of two brown edible seaweeds, Laminaria digitata (LD) and Undaria pinnatifida (UP), on postprandial glucose metabolism and appetite following a starch load in a human meal study.Methods: Twenty healthy subjects were enrolled in a randomized, 3-way, blinded cross-over trial. The study was registered under ClinicalTrials.gov Identifier no. NCT00123456. At each test day, the subjects received one of three meals comprising 30 g of starch with 5 g of LD or UP or an energy-adjusted control meal containing pea protein. Fasting and postprandial blood glucose, insulin, C-peptide and glucagon-like peptide-1 (GLP-1) concentrations were measured. Subjective appetite sensations were scored using visual analogue scales (VAS).Results: Linear mixed model (LMM) analysis showed a lower blood glucose, insulin and C-peptide response following the intake of LD and UP, after correction for body weight. Participants weighing ≤ 63 kg had a reduced glucose response compared to control meal between 40 and 90 min both following LD and UP meals. Furthermore, LMM analysis for C-peptide showed a significantly lower response after intake of LD. Compared to the control meal, GLP-1 response was higher after the LD meal, both before and after the body weight adjustment. The VAS scores showed a decreased appetite sensation after intake of the seaweeds. Ad-libitum food intake was not different three hours after the seaweed meals compared to control.Conclusions: Concomitant ingestion of brown seaweeds may help improving postprandial glycaemic and appetite control in healthy and normal weight adults, depending on the dose per body weight.Clinical trial registry number: Clinicaltrials.gov (ID# NCT02608372).

KW - Faculty of Science

KW - Bioactive foods

KW - Glycaemic response

KW - Satiety

KW - Resistant dietary fibers

KW - Starch-degrading enzymes

KW - Alpha-glucosidase

U2 - 10.1016/j.clnu.2020.08.027

DO - 10.1016/j.clnu.2020.08.027

M3 - Journal article

C2 - 32917417

VL - 40

SP - 830

EP - 838

JO - Clinical Nutrition

JF - Clinical Nutrition

SN - 0261-5614

IS - 3

ER -

ID: 248549575