Effects of sodium fluoride, vitamin D, and calcium on cortical bone remodeling in osteoporotic patients
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Effects of sodium fluoride, vitamin D, and calcium on cortical bone remodeling in osteoporotic patients. / Kragstrup, J; Shijie, Z; Mosekilde, L; Melsen, F.
In: Calcified Tissue International, Vol. 45, No. 6, 12.1989, p. 337-41.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Effects of sodium fluoride, vitamin D, and calcium on cortical bone remodeling in osteoporotic patients
AU - Kragstrup, J
AU - Shijie, Z
AU - Mosekilde, L
AU - Melsen, F
PY - 1989/12
Y1 - 1989/12
N2 - The purpose of this histomorphometric study of iliac bone biopsies from 10 postmenopausal osteoporotic patients was to describe the effects of sodium fluoride (combined with calcium and vitamin D) on remodeling in cortical bone after 6 months and after 5 years of treatment. Biopsies had been fixed in absolute methanol, embedded undecalcified in methylmetacrylate, and cut on a heavyduty microtome. The therapy had no effect on the thickness of cortical bone in the iliac crest but increased the porosity slightly. It had no statistically significant effect on depth of resorption or thickness of new walls formed at remodeling sites but treatment increased the fraction of osteons undergoing remodeling in cortical bone. After 6 months of treatment, the increase was due to an enhanced activation of new remodeling sites, but in biopsies taken after 5 years of treatment, some degree of mineralization defect was observed and the duration of the remodeling cycle appeared to be prolonged. The mechanism underlying this qualitative change in the response to treatment is unknown, and it is unclear whether the mineralization defect may be prevented by, e.g., an altered supplementation of vitamin D or calcium.
AB - The purpose of this histomorphometric study of iliac bone biopsies from 10 postmenopausal osteoporotic patients was to describe the effects of sodium fluoride (combined with calcium and vitamin D) on remodeling in cortical bone after 6 months and after 5 years of treatment. Biopsies had been fixed in absolute methanol, embedded undecalcified in methylmetacrylate, and cut on a heavyduty microtome. The therapy had no effect on the thickness of cortical bone in the iliac crest but increased the porosity slightly. It had no statistically significant effect on depth of resorption or thickness of new walls formed at remodeling sites but treatment increased the fraction of osteons undergoing remodeling in cortical bone. After 6 months of treatment, the increase was due to an enhanced activation of new remodeling sites, but in biopsies taken after 5 years of treatment, some degree of mineralization defect was observed and the duration of the remodeling cycle appeared to be prolonged. The mechanism underlying this qualitative change in the response to treatment is unknown, and it is unclear whether the mineralization defect may be prevented by, e.g., an altered supplementation of vitamin D or calcium.
KW - Aged
KW - Bone Regeneration/drug effects
KW - Bone Resorption/pathology
KW - Bone and Bones/drug effects
KW - Calcium/pharmacology
KW - Female
KW - Humans
KW - Middle Aged
KW - Osteoporosis/pathology
KW - Sodium Fluoride/pharmacology
KW - Vitamin D/pharmacology
U2 - 10.1007/BF02556003
DO - 10.1007/BF02556003
M3 - Journal article
C2 - 2509023
VL - 45
SP - 337
EP - 341
JO - Calcified Tissue International
JF - Calcified Tissue International
SN - 0171-967X
IS - 6
ER -
ID: 324193319