Effects of South African traditional medicine in animal models for depression

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Effects of South African traditional medicine in animal models for depression. / Pedersen, Mikael Egebjerg; Szewczyk, Bernadeta; Stachowicz, Katarzyna; Wieronska, Joanna; Andersen, Jacob; Stafford, Gary Ivan; van Staden, Johannes; Pilc, Andrzej; Jäger, Anna Katharina.

In: Journal of Ethnopharmacology, Vol. 119, No. 3, 2008, p. 542-548.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Pedersen, ME, Szewczyk, B, Stachowicz, K, Wieronska, J, Andersen, J, Stafford, GI, van Staden, J, Pilc, A & Jäger, AK 2008, 'Effects of South African traditional medicine in animal models for depression', Journal of Ethnopharmacology, vol. 119, no. 3, pp. 542-548. https://doi.org/10.1016/j.jep.2008.08.030

APA

Pedersen, M. E., Szewczyk, B., Stachowicz, K., Wieronska, J., Andersen, J., Stafford, G. I., van Staden, J., Pilc, A., & Jäger, A. K. (2008). Effects of South African traditional medicine in animal models for depression. Journal of Ethnopharmacology, 119(3), 542-548. https://doi.org/10.1016/j.jep.2008.08.030

Vancouver

Pedersen ME, Szewczyk B, Stachowicz K, Wieronska J, Andersen J, Stafford GI et al. Effects of South African traditional medicine in animal models for depression. Journal of Ethnopharmacology. 2008;119(3):542-548. https://doi.org/10.1016/j.jep.2008.08.030

Author

Pedersen, Mikael Egebjerg ; Szewczyk, Bernadeta ; Stachowicz, Katarzyna ; Wieronska, Joanna ; Andersen, Jacob ; Stafford, Gary Ivan ; van Staden, Johannes ; Pilc, Andrzej ; Jäger, Anna Katharina. / Effects of South African traditional medicine in animal models for depression. In: Journal of Ethnopharmacology. 2008 ; Vol. 119, No. 3. pp. 542-548.

Bibtex

@article{ffd89f70a66411ddb5e9000ea68e967b,
title = "Effects of South African traditional medicine in animal models for depression",
abstract = "ETHNOPHARMACOLOGICAL RELEVANCE: The four South African medicinal plants Agapanthus campanulatus (AC), Boophone distica (BD), Mondia whitei (MW) and Xysmalobium undulatum (XU) are used in traditional medicine to treat depression. AIM: To evaluate the effect of ethanolic extracts of the plants in models for depression. MATERIALS AND METHODS: The extracts were screened for affinity for the serotonin transporter (SERT) in the [(3)H]-citalopram-binding assay. The inhibitory potency of the extracts towards the SERT, the noradrenalin transporter (NAT) and the dopamine transporter (DAT) were determined in a functional uptake inhibition assay. Antidepressant-like effects of the extracts were investigated using the tail suspension test (TST) and the forced swim test in both rats (rFST) and mice (mFST). RESULTS: All four plants showed affinity for SERT in the binding assay. AC and BD showed functional inhibition of SERT, NAT and DAT, MW affected SERT while XU showed no effect. BD showed significant effect in the TST and in the mFST/rFST, AC showed significant effect in mFST, MW showed significant effect in the rFST and XU showed significant effect in the mFST. CONCLUSION: In this study we have demonstrated the antidepressant activity of four South African medicinal plants in vitro and in vivo, supporting their rational use in traditional medicine.",
keywords = "Former Faculty of Pharmaceutical Sciences",
author = "Pedersen, {Mikael Egebjerg} and Bernadeta Szewczyk and Katarzyna Stachowicz and Joanna Wieronska and Jacob Andersen and Stafford, {Gary Ivan} and {van Staden}, Johannes and Andrzej Pilc and J{\"a}ger, {Anna Katharina}",
note = "Keywords: Dopamine transporter inhibitors Forced swim test Norepinephrine transporter inhibitors Serotonin transporter inhibitors South African medicinal plants Tail suspension test",
year = "2008",
doi = "10.1016/j.jep.2008.08.030",
language = "English",
volume = "119",
pages = "542--548",
journal = "Journal of Ethnopharmacology",
issn = "0378-8741",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

RIS

TY - JOUR

T1 - Effects of South African traditional medicine in animal models for depression

AU - Pedersen, Mikael Egebjerg

AU - Szewczyk, Bernadeta

AU - Stachowicz, Katarzyna

AU - Wieronska, Joanna

AU - Andersen, Jacob

AU - Stafford, Gary Ivan

AU - van Staden, Johannes

AU - Pilc, Andrzej

AU - Jäger, Anna Katharina

N1 - Keywords: Dopamine transporter inhibitors Forced swim test Norepinephrine transporter inhibitors Serotonin transporter inhibitors South African medicinal plants Tail suspension test

PY - 2008

Y1 - 2008

N2 - ETHNOPHARMACOLOGICAL RELEVANCE: The four South African medicinal plants Agapanthus campanulatus (AC), Boophone distica (BD), Mondia whitei (MW) and Xysmalobium undulatum (XU) are used in traditional medicine to treat depression. AIM: To evaluate the effect of ethanolic extracts of the plants in models for depression. MATERIALS AND METHODS: The extracts were screened for affinity for the serotonin transporter (SERT) in the [(3)H]-citalopram-binding assay. The inhibitory potency of the extracts towards the SERT, the noradrenalin transporter (NAT) and the dopamine transporter (DAT) were determined in a functional uptake inhibition assay. Antidepressant-like effects of the extracts were investigated using the tail suspension test (TST) and the forced swim test in both rats (rFST) and mice (mFST). RESULTS: All four plants showed affinity for SERT in the binding assay. AC and BD showed functional inhibition of SERT, NAT and DAT, MW affected SERT while XU showed no effect. BD showed significant effect in the TST and in the mFST/rFST, AC showed significant effect in mFST, MW showed significant effect in the rFST and XU showed significant effect in the mFST. CONCLUSION: In this study we have demonstrated the antidepressant activity of four South African medicinal plants in vitro and in vivo, supporting their rational use in traditional medicine.

AB - ETHNOPHARMACOLOGICAL RELEVANCE: The four South African medicinal plants Agapanthus campanulatus (AC), Boophone distica (BD), Mondia whitei (MW) and Xysmalobium undulatum (XU) are used in traditional medicine to treat depression. AIM: To evaluate the effect of ethanolic extracts of the plants in models for depression. MATERIALS AND METHODS: The extracts were screened for affinity for the serotonin transporter (SERT) in the [(3)H]-citalopram-binding assay. The inhibitory potency of the extracts towards the SERT, the noradrenalin transporter (NAT) and the dopamine transporter (DAT) were determined in a functional uptake inhibition assay. Antidepressant-like effects of the extracts were investigated using the tail suspension test (TST) and the forced swim test in both rats (rFST) and mice (mFST). RESULTS: All four plants showed affinity for SERT in the binding assay. AC and BD showed functional inhibition of SERT, NAT and DAT, MW affected SERT while XU showed no effect. BD showed significant effect in the TST and in the mFST/rFST, AC showed significant effect in mFST, MW showed significant effect in the rFST and XU showed significant effect in the mFST. CONCLUSION: In this study we have demonstrated the antidepressant activity of four South African medicinal plants in vitro and in vivo, supporting their rational use in traditional medicine.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1016/j.jep.2008.08.030

DO - 10.1016/j.jep.2008.08.030

M3 - Journal article

C2 - 18809486

VL - 119

SP - 542

EP - 548

JO - Journal of Ethnopharmacology

JF - Journal of Ethnopharmacology

SN - 0378-8741

IS - 3

ER -

ID: 8297463